Development of dissolvable microneedle patches by CNC machining and micromolding for drug delivery

Article

Malek-Khatabi, Atefeh, Faraji Rad, Zahra, Rad-Malekshahi, Mazda and Akbarijavar, Hamid. 2023. "Development of dissolvable microneedle patches by CNC machining and micromolding for drug delivery." Materials Letters. 330, pp. 1-6. https://doi.org/10.1016/j.matlet.2022.133328
Article Title

Development of dissolvable microneedle patches by CNC machining and micromolding for drug delivery

ERA Journal ID1005
Article CategoryArticle
AuthorsMalek-Khatabi, Atefeh (Author), Faraji Rad, Zahra (Author), Rad-Malekshahi, Mazda (Author) and Akbarijavar, Hamid (Author)
Journal TitleMaterials Letters
Journal Citation330, pp. 1-6
Article Number133328
Number of Pages6
Year2023
PublisherElsevier
Place of PublicationNetherlands
ISSN0167-577X
1873-4979
Digital Object Identifier (DOI)https://doi.org/10.1016/j.matlet.2022.133328
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0167577X22016834
Abstract

This study reports the fabrication of microneedles using computer numerical control (CNC) machining and micromolding for replicating dissolvable microneedles (DMNs) for drug delivery. Despite the ease of use and simple manufacturing by CNC, this method has not been extensively studied for the fabrication of microneedles. The master molds were fabricated using CNC machining; subsequently, DMNs embedded with fluorescent dye as a drug model were prepared using a hyaluronic acid (HA) and polyvinylpyrrolidone (PVP) solution in a rapid and comparatively simple micromolding process. The microneedles were evaluated for mechanical strength and penetration efficiency. The drug diffusion from DMNs was elucidated through confocal laser scanning microscopy (CLSM) imaging. The results show that fabricated DMNs are mechanically strong enough to penetrate the skin dermis layer and deliver their therapeutic cargo. In conclusion, CNC machining can provide rapid and low-cost fabrication of master molds, facilitating DMNs production for transdermal drug delivery.

KeywordsMicroneedle; Transdermal drug delivery; CNC machining; Micromolding
ANZSRC Field of Research 2020401410. Microtechnology
400302. Biomaterials
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Byline AffiliationsTehran University of Medical Sciences, Iran
School of Engineering
Institution of OriginUniversity of Southern Queensland
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