Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

Article

Malek-Khatabi, A., Razavi, M.S., Abdollahi, A., Rahimzadeghan, M., Moammeri, F., Sheikhi, M., Tavakoli, M., Rad-Malekshahi, M. and Faraji Rad, Z.. 2023. "Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery." Biomaterials Science. 11 (16), pp. 5390-5409. https://doi.org/10.1039/D3BM00795B
Article Title

Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

ERA Journal ID200220
Article CategoryArticle
AuthorsMalek-Khatabi, A., Razavi, M.S., Abdollahi, A., Rahimzadeghan, M., Moammeri, F., Sheikhi, M., Tavakoli, M., Rad-Malekshahi, M. and Faraji Rad, Z.
Journal TitleBiomaterials Science
Journal Citation11 (16), pp. 5390-5409
Number of Pages20
Year2023
PublisherThe Royal Society of Chemistry
ISSN2047-4830
2047-4849
Digital Object Identifier (DOI)https://doi.org/10.1039/D3BM00795B
Web Address (URL)https://pubs.rsc.org/en/content/articlelanding/2023/BM/D3BM00795B
Abstract

Microneedles (MNs) have recently been found to have applications in drug, vitamin, protein and vaccine delivery. Polymeric MN arrays continue to attract increasing attention due to their capability to bypass the skin's stratum corneum (SC) barrier with minimal invasiveness. These carriers can achieve the targeted intradermal delivery of drugs and vaccines and improve their transdermal delivery level. As a nontoxic FDA-approved copolymer, polylactic glycolic acid (PLGA) has good biocompatibility and biodegradability. Currently, PLGA-based MNs have a noticeable tendency to be utilized as a delivery system. This study focuses on the most recent advances in PLGA-based MNs. Both PLGA nanoparticle-based MNs and PLGA matrix-based MNs, created for the delivery of vaccines, drugs, proteins and other therapeutic agents, are discussed. The paper also discusses the various types of MNs and their potential applications. Finally, the prospects and challenges of PLGA-based MNs are reviewed.

Keywordsdrug; vaccine; Microneedles
ANZSRC Field of Research 2020400302. Biomaterials
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Byline AffiliationsTehran University of Medical Sciences, Iran
Mazandaran University of Medical Sciences, Iran
Shahid Beheshti University, Iran
Mashhad University of Medical Sciences, Iran
School of Engineering
Centre for Future Materials
Centre for Crop Health
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