The role of microneedles in the healing of chronic wounds

Article

Ghiyasi, Yasaman, Prewett, Philip D, Davies, Graham J and Faraji Rad, Zahra. 2023. "The role of microneedles in the healing of chronic wounds." International Journal of Pharmaceutics. 641. https://doi.org/10.1016/j.ijpharm.2023.123087
Article Title

The role of microneedles in the healing of chronic wounds

ERA Journal ID14778
Article CategoryArticle
AuthorsGhiyasi, Yasaman, Prewett, Philip D, Davies, Graham J and Faraji Rad, Zahra
Journal TitleInternational Journal of Pharmaceutics
Journal Citation641
Article Number123087
Number of Pages18
Year2023
PublisherElsevier
Place of PublicationNetherlands
ISSN0378-5173
1873-3476
Digital Object Identifier (DOI)https://doi.org/10.1016/j.ijpharm.2023.123087
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0378517323005070
Abstract

Chronic wounds occur for several reasons, such as trauma, accidents, and diseases. Diabetes has been one of the primary causes of non-healing wounds, and the number of people with diabetes is increasing in most countries. Wounds in diabetic people have a complex and prolonged treatment process, with high treatment costs to both healthcare providers and patients. They often have severe consequences, such as pain, wound infection, tissue necrosis, and even limb amputation. Various methods have been used to treat chronic wounds, but clinical success has been limited due to inefficient delivery to the wound bed. Microneedles (MNs), as new platforms, can offer an effective treatment, easy to use and non-invasive with less tissue damage, capable of delivering a wide range of drugs to accelerate the wound healing process. Different methods and materials can be used for this technique, and there are different geometric parameters such as needle length, tip angle, shape and radius, together with needle array density to optimize for the most effective treatment. This review paper will investigate the role of MNs in healing chronic wounds and discuss the most recent development in MN-based devices in the field and their effectiveness. The manuscript will also discuss the various types of MNs and their potential applications for delivering therapeutic agents. Finally, the challenges associated with using MNs to heal chronic wounds and future directions in this field are discussed.

KeywordsMicroneedles; Wounds; Polymers; Transdermal drug delivery
ANZSRC Field of Research 2020400302. Biomaterials
Byline AffiliationsBu-Ali Sina University, Iran
University of Birmingham, United Kingdom
University of New South Wales
School of Engineering
Centre for Future Materials
Centre for Crop Health
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