Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles

Article


Ebrahiminejad, Vahid, Malek-Khatabi, Atefeh and Faraji Rad, Zahra. 2024. "Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles." Advanced Materials Technologies. https://doi.org/10.1002/admt.202301272
Article Title

Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles

ERA Journal ID211618
Article CategoryArticle
AuthorsEbrahiminejad, Vahid, Malek-Khatabi, Atefeh and Faraji Rad, Zahra
Journal TitleAdvanced Materials Technologies
Number of Pages16
Year2024
PublisherWiley-VCH Verlag GmbH & Co. KGaA
Place of PublicationGermany
ISSN2365-709X
Digital Object Identifier (DOI)https://doi.org/10.1002/admt.202301272
Web Address (URL)https://onlinelibrary.wiley.com/doi/full/10.1002/admt.202301272
Abstract

Microneedles (MNs) offer a promising solution for increasing the effectiveness of transdermal drug delivery and diagnostics. However, challenges such as large-scale manufacturing, partial MN penetration, and uncontrolled drug delivery limit the effectiveness of the technology. To overcome these challenges, current research examines the effects of skin strain and vibration on MN insertion and drug delivery. A novel multifeatured impact applicator are developed for improving skin insertion that features a combination of skin stretching, eccentric rotating mass (ERM), and linear resonant actuator (LRA) micro-vibration capabilities. In addition, a scalable replication method for dissolving microneedle patches (DMNPs) are developed using two-photon polymerization (TPP) and soft embossing processes. The DMNPs are used to evaluate the diffusion and concentration of a model drug, fluorescein sodium salt (FSS), when applied using ERM and LRA micro-vibration at different frequencies. Additionally, a new computer simulation method is presented to model the MN insertion into the multilayered hyperelastic skin model, incorporating skin strain and vibrational effects. The results indicate that applying skin strain and vibration decreases the force required for MN insertion and enhances the dissolution and diffusion depth of the drug in the skin, which can enhance the drug permeability and effectiveness of MN devices.

KeywordsMicroneedles; skin strain; Low-Frequency Vibration
ANZSRC Field of Research 2020400399. Biomedical engineering not elsewhere classified
401410. Microtechnology
Byline AffiliationsSchool of Engineering
Tehran University of Medical Sciences, Iran
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