Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles
Article
Article Title | Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles |
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ERA Journal ID | 211618 |
Article Category | Article |
Authors | Ebrahiminejad, Vahid, Malek-Khatabi, Atefeh and Faraji Rad, Zahra |
Journal Title | Advanced Materials Technologies |
Journal Citation | 9 (4) |
Article Number | 2301272 |
Number of Pages | 16 |
Year | 2024 |
Publisher | Wiley-VCH Verlag GmbH & Co. KGaA |
Place of Publication | Germany |
ISSN | 2365-709X |
Digital Object Identifier (DOI) | https://doi.org/10.1002/admt.202301272 |
Web Address (URL) | https://onlinelibrary.wiley.com/doi/full/10.1002/admt.202301272 |
Abstract | Microneedles (MNs) offer a promising solution for increasing the effectiveness of transdermal drug delivery and diagnostics. However, challenges such as large-scale manufacturing, partial MN penetration, and uncontrolled drug delivery limit the effectiveness of the technology. To overcome these challenges, current research examines the effects of skin strain and vibration on MN insertion and drug delivery. A novel multifeatured impact applicator are developed for improving skin insertion that features a combination of skin stretching, eccentric rotating mass (ERM), and linear resonant actuator (LRA) micro-vibration capabilities. In addition, a scalable replication method for dissolving microneedle patches (DMNPs) are developed using two-photon polymerization (TPP) and soft embossing processes. The DMNPs are used to evaluate the diffusion and concentration of a model drug, fluorescein sodium salt (FSS), when applied using ERM and LRA micro-vibration at different frequencies. Additionally, a new computer simulation method is presented to model the MN insertion into the multilayered hyperelastic skin model, incorporating skin strain and vibrational effects. The results indicate that applying skin strain and vibration decreases the force required for MN insertion and enhances the dissolution and diffusion depth of the drug in the skin, which can enhance the drug permeability and effectiveness of MN devices. |
Keywords | Microneedles; skin strain; Low-Frequency Vibration |
ANZSRC Field of Research 2020 | 400399. Biomedical engineering not elsewhere classified |
401410. Microtechnology | |
Byline Affiliations | School of Engineering |
Tehran University of Medical Sciences, Iran |
https://research.usq.edu.au/item/z4xv9/influence-of-low-frequency-vibration-and-skin-strain-on-insertion-mechanics-and-drug-diffusion-of-pva-pvp-dissolving-microneedles
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Adv Materials Technologies - 2024 - Ebrahiminejad - Influence of Low‐Frequency Vibration and Skin Strain on Insertion.pdf | ||
License: CC BY-NC 4.0 | ||
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