Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques

Article

Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques." Manufacturing Letters. 30, pp. 39-43. https://doi.org/10.1016/j.mfglet.2021.10.007
Article Title

Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques

ERA Journal ID213619
Article CategoryArticle
AuthorsFaraji Rad, Zahra (Author), Prewett, Philip (Author) and Davies, Graham (Author)
Journal TitleManufacturing Letters
Journal Citation30, pp. 39-43
Number of Pages5
Year2021
PublisherElsevier BV
Place of PublicationNetherlands
ISSN2213-8463
Digital Object Identifier (DOI)https://doi.org/10.1016/j.mfglet.2021.10.007
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S2213846321000821
Abstract

In recent years, interest in microneedle devices for drug and vaccine delivery and point-of-care diagnostics has grown due to low cost, convenience and minimal invasiveness. A cluster of miniature needles on a small patch could enhance the quality of human health care, revolutionizing test and drug and vaccine delivery systems. However, current fabrication methods are not viable for cost-effective large-scale manufacture. This study reports fabrication of ultra-sharp microneedles with microfluidic channels using two-photon polymerization (2PP) which enables flexible designs with resolution down to 100 nm. The technique is ideally suited to prototyping and the fabrication of master molds from which elastomeric negative-molds have been used in a rapid micromolding technique to make batches of ultra-sharp microneedles. This micromolding process has mass manufacturing potential.

KeywordsDrug delivery; Micro/nanofabrication; Micromolding; Microneedles; Point-of-care diagnostics; Two-photon polymerization
ANZSRC Field of Research 2020401401. Additive manufacturing
400303. Biomechanical engineering
400302. Biomaterials
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsSchool of Mechanical and Electrical Engineering
University of Birmingham, United Kingdom
University of New South Wales
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q7191/rapid-prototyping-and-customizable-microneedle-design-ultra-sharp-microneedle-fabrication-using-two-photon-polymerization-and-low-cost-micromolding-techniques

Log in to edit
  • 111
    total views
  • 3
    total downloads
  • 2
    views this month
  • 0
    downloads this month

Export as

Related outputs

Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses
Babapour, Fatemeh, Faraji Rad, Zahra and Ganji, Fariba. 2024. "Mechanics of dissolving microneedles insertion into the skin: Finite element and experimental analyses." Journal of Applied Polymer Science. 141 (38). https://doi.org/10.1002/app.55973
The advantages of microneedle patches compared to conventional needle-based drug delivery and biopsy devices in medicine
Reinke, Alissa, Whiteside, Eliza J, Windus, Louisa, Desai, Devang, Stehr, Emma and Faraji Rad, Zahra. 2024. "The advantages of microneedle patches compared to conventional needle-based drug delivery and biopsy devices in medicine." Biomedical Engineering Advances. 8. https://doi.org/10.1016/j.bea.2024.100127
Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles
Ebrahiminejad, Vahid, Malek-Khatabi, Atefeh and Faraji Rad, Zahra. 2024. "Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles." Advanced Materials Technologies. 9 (4). https://doi.org/10.1002/admt.202301272
Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle-Based Biosensors
Saifullah, Khaled Mohammed and Faraji Rad, Zahra. 2023. "Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle-Based Biosensors." Advanced Materials Interfaces. 10 (10). https://doi.org/10.1002/admi.202201763
Botulinum toxin A dissolving microneedles for hyperhidrosis treatment: design, formulation and in vivo evaluation
Malek-Khatabi, Atefeh, Rad-Malekshahi, Mazda, Shafiei, Morvarid, Sharifi, Fatemeh, Motasadizadeh, Hamidreza, Ebrahiminejad, Vahid, Rad-Malekshahi, Mazdak, Akbarijavar, Hamid and Faraji Rad, Zahra. 2023. "Botulinum toxin A dissolving microneedles for hyperhidrosis treatment: design, formulation and in vivo evaluation." Biomaterials Science. 11 (24), pp. 7784-7804. https://doi.org/10.1039/d3bm01301d
The role of microneedles in the healing of chronic wounds
Ghiyasi, Yasaman, Prewett, Philip D, Davies, Graham J and Faraji Rad, Zahra. 2023. "The role of microneedles in the healing of chronic wounds." International Journal of Pharmaceutics. 641. https://doi.org/10.1016/j.ijpharm.2023.123087
Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery
Malek-Khatabi, A., Razavi, M.S., Abdollahi, A., Rahimzadeghan, M., Moammeri, F., Sheikhi, M., Tavakoli, M., Rad-Malekshahi, M. and Faraji Rad, Z.. 2023. "Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery." Biomaterials Science. 11 (16), pp. 5390-5409. https://doi.org/10.1039/D3BM00795B
Microneedle patches – the future of drug delivery and vaccination?
Faraji Rad, Zahra, Prewett, Philip D. and Davies, Davies. 2023. "Microneedle patches – the future of drug delivery and vaccination?" Beilstein Journal of Nanotechnology. 14, pp. 494-495. https://doi.org/10.3762/bjnano.14.40
Bioinspired Strong, Tough, and Biodegradable Poly(Vinyl Alcohol) and its Applications as Substrates for Humidity Sensors
Liu, Lei, Xu, Xiaodong, Zhu, Menghe, Cui, Xihua, Feng, Jiabing, Faraji Rad, Zahra, Wang, Hao and Song, Pingan. 2023. "Bioinspired Strong, Tough, and Biodegradable Poly(Vinyl Alcohol) and its Applications as Substrates for Humidity Sensors." Advanced Materials Technologies. https://doi.org/10.1002/admt.202201414
Development of dissolvable microneedle patches by CNC machining and micromolding for drug delivery
Malek-Khatabi, Atefeh, Faraji Rad, Zahra, Rad-Malekshahi, Mazda and Akbarijavar, Hamid. 2023. "Development of dissolvable microneedle patches by CNC machining and micromolding for drug delivery." Materials Letters. 330, pp. 1-6. https://doi.org/10.1016/j.matlet.2022.133328
Microneedle Technologies for Food and Crop Health: Recent Advances and Future Perspectives
Faraji Rad, Zahra. 2023. "Microneedle Technologies for Food and Crop Health: Recent Advances and Future Perspectives." Advanced Engineering Materials. 25 (4). https://doi.org/10.1002/adem.202201194
Fabrication and testing of polymer microneedles for transdermal drug delivery
Ebrahiminejad, Vahid, Faraji Rad, Zahra, Prewett, Philip D. and Davies, Graham J.. 2022. "Fabrication and testing of polymer microneedles for transdermal drug delivery." Beilstein Journal of Nanotechnology. 13, pp. 629-640. https://doi.org/10.3762/bjnano.13.55
Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications
Ebrahiminejad, Vahid and Faraji Rad, Zahra. 2022. "Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications." Advanced Materials Interfaces. 9 (29). https://doi.org/10.1002/admi.202201115
Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration
Ebrahiminejad, Vahid, Prewett, Philip D., Davies, Graham J. and Faraji Rad, Zahra. 2022. "Microneedle Arrays for Drug Delivery and Diagnostics: Toward an Optimized Design, Reliable Insertion, and Penetration." Advanced Materials Interfaces. 9 (6), pp. 1-26. https://doi.org/10.1002/admi.202101856
Parametric optimization of two-photon direct laser writing process for manufacturing polymeric microneedles
Faraji Rad, Zahra, Prewett, Philip D. and Davies, Graham J.. 2022. "Parametric optimization of two-photon direct laser writing process for manufacturing polymeric microneedles." Additive Manufacturing. 56, pp. 1-14. https://doi.org/10.1016/j.addma.2022.102953
High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays
Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays." Microsystems and Nanoengineering. 7 (1), pp. 1-17. https://doi.org/10.1038/s41378-021-00298-3
An overview of microneedle applications, materials, and fabrication methods
Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "An overview of microneedle applications, materials, and fabrication methods." Beilstein Journal of Nanotechnology. 12, pp. 1034-1046. https://doi.org/10.3762/bjnano.12.77
High-fidelity replication of thermoplastic microneedles with open microfluidic channels
Faraji Rad, Zahra, Nordon, Robert E., Anthony, Carl J., Bilston, Lynne, Prewett, Philip D., Arns, Ji-Youn, Arns, Christoph H., Zhang, Liangchi and Davies, Graham J.. 2017. "High-fidelity replication of thermoplastic microneedles with open microfluidic channels." Microsystems and Nanoengineering. 3, pp. 1-11. https://doi.org/10.1038/micronano.2017.34
Carbon-based nanostructures for cancer therapy and drug delivery applications
Bagheri, Babak, Surwase, Sachin S., Lee, Su Sam, Park, Heewon, Faraji Rad, Zahra, Trevaskis, Natalie L. and Kim, Yeu-Chun. 2022. "Carbon-based nanostructures for cancer therapy and drug delivery applications." Journal of Materials Chemistry B. 10 (48), pp. 9944-9967. https://doi.org/10.1039/d2tb01741e
A roof cavability classification system and its use for estimation of main caving interval in longwall mining
Mohammadi, Sodjad, Ataei, Mohammad, Kakaie, Reza, Mirzaghorbanali, Ali, Faraji Rad, Zahra and Aziz, Naj. 2020. "A roof cavability classification system and its use for estimation of main caving interval in longwall mining." Aziz, Naj and Kininmonth, Bob (ed.) 2020 Coal Operators' Conference. Wollongong, Australia 18 - 20 Feb 2019 Wollongong, Australia.
Microfluidic devices and fabrication
Faraji Rad, Zahra, Nordon, Robert, Davies, Graham, Anthony, Carl john and Prewett, Philip. 2020. Microfluidic devices and fabrication. 10850082