Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques

Article

Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques." Manufacturing Letters. 30, pp. 39-43. https://doi.org/10.1016/j.mfglet.2021.10.007
Article Title

Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques

ERA Journal ID213619
Article CategoryArticle
AuthorsFaraji Rad, Zahra (Author), Prewett, Philip (Author) and Davies, Graham (Author)
Journal TitleManufacturing Letters
Journal Citation30, pp. 39-43
Number of Pages5
Year2021
PublisherElsevier BV
Place of PublicationNetherlands
ISSN2213-8463
Digital Object Identifier (DOI)https://doi.org/10.1016/j.mfglet.2021.10.007
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S2213846321000821
Abstract

In recent years, interest in microneedle devices for drug and vaccine delivery and point-of-care diagnostics has grown due to low cost, convenience and minimal invasiveness. A cluster of miniature needles on a small patch could enhance the quality of human health care, revolutionizing test and drug and vaccine delivery systems. However, current fabrication methods are not viable for cost-effective large-scale manufacture. This study reports fabrication of ultra-sharp microneedles with microfluidic channels using two-photon polymerization (2PP) which enables flexible designs with resolution down to 100 nm. The technique is ideally suited to prototyping and the fabrication of master molds from which elastomeric negative-molds have been used in a rapid micromolding technique to make batches of ultra-sharp microneedles. This micromolding process has mass manufacturing potential.

KeywordsDrug delivery; Micro/nanofabrication; Micromolding; Microneedles; Point-of-care diagnostics; Two-photon polymerization
ANZSRC Field of Research 2020401401. Additive manufacturing
400303. Biomechanical engineering
400302. Biomaterials
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Byline AffiliationsSchool of Mechanical and Electrical Engineering
University of Birmingham, United Kingdom
University of New South Wales
Institution of OriginUniversity of Southern Queensland
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