Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques
Article
Article Title | Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques |
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ERA Journal ID | 213619 |
Article Category | Article |
Authors | Faraji Rad, Zahra (Author), Prewett, Philip (Author) and Davies, Graham (Author) |
Journal Title | Manufacturing Letters |
Journal Citation | 30, pp. 39-43 |
Number of Pages | 5 |
Year | 2021 |
Publisher | Elsevier BV |
Place of Publication | Netherlands |
ISSN | 2213-8463 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.mfglet.2021.10.007 |
Web Address (URL) | https://www.sciencedirect.com/science/article/pii/S2213846321000821 |
Abstract | In recent years, interest in microneedle devices for drug and vaccine delivery and point-of-care diagnostics has grown due to low cost, convenience and minimal invasiveness. A cluster of miniature needles on a small patch could enhance the quality of human health care, revolutionizing test and drug and vaccine delivery systems. However, current fabrication methods are not viable for cost-effective large-scale manufacture. This study reports fabrication of ultra-sharp microneedles with microfluidic channels using two-photon polymerization (2PP) which enables flexible designs with resolution down to 100 nm. The technique is ideally suited to prototyping and the fabrication of master molds from which elastomeric negative-molds have been used in a rapid micromolding technique to make batches of ultra-sharp microneedles. This micromolding process has mass manufacturing potential. |
Keywords | Drug delivery; Micro/nanofabrication; Micromolding; Microneedles; Point-of-care diagnostics; Two-photon polymerization |
ANZSRC Field of Research 2020 | 401401. Additive manufacturing |
400303. Biomechanical engineering | |
400302. Biomaterials | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | School of Mechanical and Electrical Engineering |
University of Birmingham, United Kingdom | |
University of New South Wales | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q7191/rapid-prototyping-and-customizable-microneedle-design-ultra-sharp-microneedle-fabrication-using-two-photon-polymerization-and-low-cost-micromolding-techniques
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