An overview of microneedle applications, materials, and fabrication methods

Article


Faraji Rad, Zahra, Prewett, Philip and Davies, Graham. 2021. "An overview of microneedle applications, materials, and fabrication methods." Beilstein Journal of Nanotechnology. 12, pp. 1034-1046. https://doi.org/10.3762/bjnano.12.77
Article Title

An overview of microneedle applications, materials, and fabrication methods

ERA Journal ID200204
Article CategoryArticle
AuthorsFaraji Rad, Zahra (Author), Prewett, Philip (Author) and Davies, Graham (Author)
Journal TitleBeilstein Journal of Nanotechnology
Journal Citation12, pp. 1034-1046
Number of Pages13
Year2021
PublisherBeilstein Institut
Place of PublicationGermany
ISSN2190-4286
Digital Object Identifier (DOI)https://doi.org/10.3762/bjnano.12.77
Web Address (URL)https://www.beilstein-journals.org/bjnano/articles/12/77
Abstract

Microneedle-based microdevices promise to expand the scope for delivery of vaccines and therapeutic agents through the skin and withdrawing biofluids for point-of-care diagnostics - so-called theranostics. Unskilled and painless applications of microneedle patches for blood collection or drug delivery are two of the advantages of microneedle arrays over hypodermic needles. Developing the necessary microneedle fabrication processes has the potential to dramatically impact the health care delivery system by changing the landscape of fluid sampling and subcutaneous drug delivery. Microneedle designs which range from sub-micron to millimetre feature sizes are fabricated using the tools of the microelectronics industry from metals, silicon, and polymers. Various types of subtractive and additive manufacturing processes have been used to manufacture microneedles, but the development of microneedle-based systems using conventional subtractive methods has been constrained by the limitations and high cost of microfabrication technology. Additive manufacturing processes such as 3D printing and two-photon polymerization fabrication are promising transformative technologies developed in recent years. The present article provides an overview of microneedle systems applications, designs, material selection, and manufacturing methods.

Keywordsdrug delivery; microelectromechanical systems (MEMS); microfabrication; microneedles; point-of-care diagnostics
ANZSRC Field of Research 2020400305. Biomedical instrumentation
400303. Biomechanical engineering
400302. Biomaterials
Byline AffiliationsSchool of Mechanical and Electrical Engineering
University of Birmingham, United Kingdom
University of New South Wales
Institution of OriginUniversity of Southern Queensland
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