Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications
Article
Article Title | Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications |
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ERA Journal ID | 210043 |
Article Category | Article |
Authors | Ebrahiminejad, Vahid (Author) and Faraji Rad, Zahra (Author) |
Journal Title | Advanced Materials Interfaces |
Journal Citation | 9 (29) |
Article Number | 2201115 |
Number of Pages | 16 |
Year | 2022 |
Publisher | John Wiley & Sons |
Place of Publication | Germany |
ISSN | 2196-7350 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/admi.202201115 |
Web Address (URL) | https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202201115 |
Abstract | Conventional microneedles (MNs) are designed as an array of micrometer-sized projections that can painlessly penetrate the skin. Fabrication of MN arrays can be costly and time-consuming; additionally, full penetration of an array of MNs with ten to thousands of projections into the skin may not be achievable. This paper reports a new design of MNs known as microblades (MBs) which consist of a singular microstructure. The single integrated design of the MBs reduces the fabrication cost and time, facilitates more effective penetration, and may pave the way for the scale-up manufacturing of MN devices. Different designs of MBs are fabricated by two-photon polym-erization technique, followed by polydimethylsiloxane micromolding and soft embossing to create replicas. The mechanical integrity of the designs is deter-mined by a series of compression tests. Skin insertion and drug diffusion studies are conducted using a custom-made applicator to insert the MBs into the porcine abdominal skin to demonstrate delivery of fluorescein tracer. MBs insertion and penetration capabilities and the diffusion of a model drug into a multi-layered human skin are demonstrated using finite element analysis and 3D diffusion models. The results demonstrate the functional capabilities of the MBs as an alternative to MN arrays. |
Keywords | drug delivery, microblade, micromolding, microneedle, two-photon polymerization |
Related Output | |
Is part of | Design and fabrication of microneedle patches, microblades and featured insertion applicator for optimising transdermal drug delivery |
ANZSRC Field of Research 2020 | 401705. Microelectromechanical systems (MEMS) |
400303. Biomechanical engineering | |
401801. Micro- and nanosystems | |
400308. Medical devices | |
400302. Biomaterials | |
Public Notes | This article is part of a UniSQ Thesis by publication. See Related Output. |
Byline Affiliations | School of Engineering |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q7qy4/design-development-and-testing-of-polymeric-microblades-a-novel-design-of-microneedles-for-biomedical-applications
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