Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications

Article


Ebrahiminejad, Vahid and Faraji Rad, Zahra. 2022. "Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications." Advanced Materials Interfaces. 9 (29). https://doi.org/10.1002/admi.202201115
Article Title

Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications

ERA Journal ID210043
Article CategoryArticle
AuthorsEbrahiminejad, Vahid (Author) and Faraji Rad, Zahra (Author)
Journal TitleAdvanced Materials Interfaces
Journal Citation9 (29)
Article Number2201115
Number of Pages16
Year2022
PublisherJohn Wiley & Sons
Place of PublicationGermany
ISSN2196-7350
Digital Object Identifier (DOI)https://doi.org/10.1002/admi.202201115
Web Address (URL)https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202201115
Abstract

Conventional microneedles (MNs) are designed as an array of micrometer-sized projections that can painlessly penetrate the skin. Fabrication of MN arrays can be costly and time-consuming; additionally, full penetration of an array of MNs with ten to thousands of projections into the skin may not be achievable. This paper reports a new design of MNs known as microblades (MBs) which consist of a singular microstructure. The single integrated design of the MBs reduces the fabrication cost and time, facilitates more effective penetration, and may pave the way for the scale-up manufacturing of MN devices. Different designs of MBs are fabricated by two-photon polym-erization technique, followed by polydimethylsiloxane micromolding and soft embossing to create replicas. The mechanical integrity of the designs is deter-mined by a series of compression tests. Skin insertion and drug diffusion studies are conducted using a custom-made applicator to insert the MBs into the porcine abdominal skin to demonstrate delivery of fluorescein tracer. MBs insertion and penetration capabilities and the diffusion of a model drug into a multi-layered human skin are demonstrated using finite element analysis and 3D diffusion models. The results demonstrate the functional capabilities of the MBs as an alternative to MN arrays.

Keywordsdrug delivery, microblade, micromolding, microneedle, two-photon polymerization
Related Output
Is part ofDesign and fabrication of microneedle patches, microblades and featured insertion applicator for optimising transdermal drug delivery
ANZSRC Field of Research 2020401705. Microelectromechanical systems (MEMS)
400303. Biomechanical engineering
401801. Micro- and nanosystems
400308. Medical devices
400302. Biomaterials
Public Notes

This article is part of a UniSQ Thesis by publication. See Related Output.

Byline AffiliationsSchool of Engineering
Institution of OriginUniversity of Southern Queensland
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