Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle-Based Biosensors
Article
Article Title | Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle-Based Biosensors |
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ERA Journal ID | 210043 |
Article Category | Article |
Authors | Saifullah, Khaled Mohammed and Faraji Rad, Zahra |
Journal Title | Advanced Materials Interfaces |
Journal Citation | 10 (10) |
Article Number | 2201763 |
Number of Pages | 23 |
Year | 19 Feb 2023 |
Publisher | John Wiley & Sons |
Place of Publication | Germany |
ISSN | 2196-7350 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/admi.202201763 |
Web Address (URL) | https://onlinelibrary.wiley.com/doi/10.1002/admi.202201763 |
Abstract | Although interstitial fluid (ISF) is recognized as an important source of biomarkers, it is difficult and time-consuming to extract, thus limiting its use in medical diagnostic and clinical settings. An inexpensive and effective technique for accessing ISF could benefit people with various health conditions and offer platforms for on-device sensing biomarkers. Microneedles (MNs) are minimally invasive devices that have gained extensive interest over recent decades. MNs can address some of the challenges associated with ISF extraction and sensing. Accessing ISF using MNs has the potential to develop advanced, non-invasive point-of-care (POC) microdevices that enable detection or continuous monitoring within the dermal ISF, therefore drastically impacting the healthcare system. This review describes recent studies exploring MN devices for ISF sampling and sensing. Several extraction processes, sampling volume, sampling duration, integration with biosensors, sensing of biomarkers, and subsequent analysis of ISF are discussed in detail. Furthermore, opportunities, conclusions, and future prospects for developing new research in the field are also discussed. |
Keywords | biosensing; biosensors; interstitial fluid; microneedles; point-of-care diagnostics |
ANZSRC Field of Research 2020 | 401410. Microtechnology |
401210. Microfluidics and nanofluidics | |
Byline Affiliations | School of Engineering |
https://research.usq.edu.au/item/x8z96/sampling-dermal-interstitial-fluid-using-microneedles-a-review-of-recent-developments-in-sampling-methods-and-microneedle-based-biosensors
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Adv Materials Inter - 2023 - Saifullah - Sampling Dermal Interstitial Fluid Using Microneedles A Review of Recent.pdf | ||
License: CC BY 4.0 | ||
File access level: Anyone |
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