Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
Article
Article Title | Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway |
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ERA Journal ID | 13102 |
Article Category | Article |
Authors | Matigan, N. (Author), Windus, L. (Author), Smith, H. (Author), Filippich, C. (Author), Pantelis, C. (Author), McGrath, J. (Author), Mowry, B. (Author) and Hayward, N. (Author) |
Journal Title | Molecular Psychiatry |
Journal Citation | 12 (9), pp. 815-825 |
Number of Pages | 11 |
Year | 2007 |
Place of Publication | United Kingdom |
ISSN | 1359-4184 |
1476-5578 | |
Digital Object Identifier (DOI) | https://doi.org/10.1038/sj.mp.4001998 |
Web Address (URL) | https://www.nature.com/articles/4001998 |
Abstract | To identify genes dysregulated in bipolar disorder (BD1), we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls, we compared expression profiles in lymphoblastoid cell lines from monozygotic twin pairs discordant for the disease. We identified 82 genes that were differentially expressed by ⩾1.3-fold in three BD1 cases compared to their co-twins, and which were statistically (P⩽0.05) differentially expressed between the groups of BD1 cases and controls. Using quantitative reverse transcriptase-polymerase chain reaction, we confirmed the differential expression of some of these genes, including: KCNK1, MAL, PFN2, TCF7, PGK1 and PI4KCB, in at least two of the twin pairs. In contrast to the findings of a previous study by Kakiuchi and colleagues with similar discordant BD1 twin design, our data do not support the dysregulation of XBP1 and HSPA5. From pathway and gene ontology analysis, we identified upregulation of the WNT signalling pathway and the biological process of apoptosis. The differentially regulated genes and pathways identified in this study may provide insights into the biology of BD1. |
Keywords | apoptosis; bipolar disorder; microarrays; monozygotic twins; WNT pathway |
ANZSRC Field of Research 2020 | 310505. Gene expression (incl. microarray and other genome-wide approaches) |
Open access url | https://www.nature.com/articles/4001998 |
Institution of Origin | University of Southern Queensland |
Byline Affiliations | Queensland Centre for Mental Health Research, Australia |
Queensland Institute of Medical Research, Australia | |
University of Melbourne | |
University of Queensland | |
Funding source | NHMRC |
https://research.usq.edu.au/item/q5z38/expression-profiling-in-monozygotic-twins-discordant-for-bipolar-disorder-reveals-dysregulation-of-the-wnt-signalling-pathway
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