Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway

Article

Matigan, N., Windus, L., Smith, H., Filippich, C., Pantelis, C., McGrath, J., Mowry, B. and Hayward, N.. 2007. "Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway." Molecular Psychiatry. 12 (9), pp. 815-825. https://doi.org/10.1038/sj.mp.4001998
Article Title

Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway

ERA Journal ID13102
Article CategoryArticle
AuthorsMatigan, N. (Author), Windus, L. (Author), Smith, H. (Author), Filippich, C. (Author), Pantelis, C. (Author), McGrath, J. (Author), Mowry, B. (Author) and Hayward, N. (Author)
Journal TitleMolecular Psychiatry
Journal Citation12 (9), pp. 815-825
Number of Pages11
Year2007
Place of PublicationUnited Kingdom
ISSN1359-4184
1476-5578
Digital Object Identifier (DOI)https://doi.org/10.1038/sj.mp.4001998
Web Address (URL)https://www.nature.com/articles/4001998
Abstract

To identify genes dysregulated in bipolar disorder (BD1), we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls, we compared expression profiles in lymphoblastoid cell lines from monozygotic twin pairs discordant for the disease. We identified 82 genes that were differentially expressed by ⩾1.3-fold in three BD1 cases compared to their co-twins, and which were statistically (P⩽0.05) differentially expressed between the groups of BD1 cases and controls. Using quantitative reverse transcriptase-polymerase chain reaction, we confirmed the differential expression of some of these genes, including: KCNK1, MAL, PFN2, TCF7, PGK1 and PI4KCB, in at least two of the twin pairs. In contrast to the findings of a previous study by Kakiuchi and colleagues with similar discordant BD1 twin design, our data do not support the dysregulation of XBP1 and HSPA5. From pathway and gene ontology analysis, we identified upregulation of the WNT signalling pathway and the biological process of apoptosis. The differentially regulated genes and pathways identified in this study may provide insights into the biology of BD1.

Keywordsapoptosis; bipolar disorder; microarrays; monozygotic twins; WNT pathway
ANZSRC Field of Research 2020310505. Gene expression (incl. microarray and other genome-wide approaches)
Open access urlhttps://www.nature.com/articles/4001998
Institution of OriginUniversity of Southern Queensland
Byline AffiliationsQueensland Centre for Mental Health Research, Australia
Queensland Institute of Medical Research, Australia
University of Melbourne
University of Queensland
Funding source
NHMRC
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