Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia
Article
Article Title | Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia |
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ERA Journal ID | 13155 |
Article Category | Article |
Authors | Windus, Louisa C. E. (Author), Claxton, C. (Author), Allen, C. (Author), Key, B. (Author) and St John, J. (Author) |
Journal Title | Glia |
Journal Citation | 55 (15), pp. 1708-1719 |
Number of Pages | 12 |
Year | 2007 |
Place of Publication | United States |
ISSN | 0894-1491 |
1098-1136 | |
Digital Object Identifier (DOI) | https://doi.org/10.1002/glia.20586 |
Web Address (URL) | https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.20586 |
Abstract | Olfactory ensheathing cells (OECs) are candidates for therapeutic approaches for neural regeneration due to their ability to assist axon regrowth in central nervous system lesion models. However, little is understood about the processes and mechanisms underlying migration of these cells. We report here that novel lamellipodial protrusions, termed lamellipodial waves, are integral to OEC migration. Time-lapse imaging of migrating OECs revealed that these highly dynamic waves progress along the shaft of the cells and are crucial for mediating cell-cell adhesion. Without these waves, cell-cell adhesion does not occur and migrational rates decline. The activity of waves is modulated by both glial cell line-derived neurotrophic factor and inhibitors of the JNK and SRC kinases. Furthermore, the activity of lamellipodial waves can be modulated by Mek1, independently of leading edge activity. The ability to selectively regulate cell migration via lamellipodial waves has implications for manipulating the migratory behavior of OECs during neural repair. |
Keywords | lamellipodia; olfactory ensheathing cell; repulsion; GDNF;Mek1 |
ANZSRC Field of Research 2020 | 310105. Cellular interactions (incl. adhesion, matrix, cell wall) |
Public Notes | File reproduced in accordance with the copyright policy of the publisher/author. |
Byline Affiliations | University of Queensland |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q5z3v/motile-membrane-protrusions-regulate-cell-cell-adhesion-and-migration-of-olfactory-ensheathing-glia
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