Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia

Article


Windus, Louisa C. E., Claxton, C., Allen, C., Key, B. and St John, J.. 2007. "Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia." Glia. 55 (15), pp. 1708-1719. https://doi.org/10.1002/glia.20586
Article Title

Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia

ERA Journal ID13155
Article CategoryArticle
AuthorsWindus, Louisa C. E. (Author), Claxton, C. (Author), Allen, C. (Author), Key, B. (Author) and St John, J. (Author)
Journal TitleGlia
Journal Citation55 (15), pp. 1708-1719
Number of Pages12
Year2007
Place of PublicationUnited States
ISSN0894-1491
1098-1136
Digital Object Identifier (DOI)https://doi.org/10.1002/glia.20586
Web Address (URL)https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.20586
Abstract

Olfactory ensheathing cells (OECs) are candidates for therapeutic approaches for neural regeneration due to their ability to assist axon regrowth in central nervous system lesion models. However, little is understood about the processes and mechanisms underlying migration of these cells. We report here that novel lamellipodial protrusions, termed lamellipodial waves, are integral to OEC migration. Time-lapse imaging of migrating OECs revealed that these highly dynamic waves progress along the shaft of the cells and are crucial for mediating cell-cell adhesion. Without these waves, cell-cell adhesion does not occur and migrational rates decline. The activity of waves is modulated by both glial cell line-derived neurotrophic factor and inhibitors of the JNK and SRC kinases. Furthermore, the activity of lamellipodial waves can be modulated by Mek1, independently of leading edge activity. The ability to selectively regulate cell migration via lamellipodial waves has implications for manipulating the migratory behavior of OECs during neural repair.

Keywordslamellipodia; olfactory ensheathing cell; repulsion; GDNF;Mek1
ANZSRC Field of Research 2020310105. Cellular interactions (incl. adhesion, matrix, cell wall)
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Byline AffiliationsUniversity of Queensland
Institution of OriginUniversity of Southern Queensland
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