Evidence of altered prefrontal–thalamic circuitry in schizophrenia: An optimized diffusion MRI study

Article

Rose, S., Chalk, J., Janke, A., Strudwick, M., Windus, Louisa C., Hannah, D., McGrath, J., Pantelis, C., Wood, S. and Mowry, B.. 2006. "Evidence of altered prefrontal–thalamic circuitry in schizophrenia: An optimized diffusion MRI study." NeuroImage. 32 (1), pp. 16-22. https://doi.org/10.1016/j.neuroimage.2006.03.003
Article Title

Evidence of altered prefrontal–thalamic circuitry in schizophrenia: An optimized diffusion MRI study

ERA Journal ID16649
Article CategoryArticle
AuthorsRose, S. (Author), Chalk, J. (Author), Janke, A. (Author), Strudwick, M. (Author), Windus, Louisa C. (Author), Hannah, D. (Author), McGrath, J. (Author), Pantelis, C. (Author), Wood, S. (Author) and Mowry, B. (Author)
Journal TitleNeuroImage
Journal Citation32 (1), pp. 16-22
Number of Pages7
Year2006
Place of PublicationNetherlands
ISSN1053-8119
1095-9572
Digital Object Identifier (DOI)https://doi.org/10.1016/j.neuroimage.2006.03.003
Web Address (URL)https://www.sciencedirect.com/science/article/abs/pii/S1053811906001789
Abstract

MRI diffusion tensor imaging (DTI), optimized for measuring the trace of the diffusion tensor, was used to investigate microstructural changes in the brains of 12 individuals with schizophrenia compared with 12 matched control subjects. To control for the effects of anatomic variation between subject groups, all participants' diffusion images were nonlinearly registered to standard anatomical space. Significant statistical differences in mean diffusivity (MD) measures between the two groups were determined on a pixel-by-pixel basis, using Gaussian random field theory. We found significantly elevated MD measures within temporal, parietal and prefrontal cortical regions in the schizophrenia group (P > 0.001), especially within the medial frontal gyrus and anterior cingulate. The dorsal medial and anterior nucleus of the thalamus, including the caudate, also exhibited significantly increased MD in the schizophrenia group (P > 0.001). This study has shown for the first time that MD measures offer an alternative strategy for investigating altered prefrontal–thalamic circuitry in schizophrenia.

KeywordsSchizophrenia; Diffusion MRI; Thalamus; Anterior cingulate
ANZSRC Field of Research 2020310199. Biochemistry and cell biology not elsewhere classified
Institution of OriginUniversity of Southern Queensland
Byline AffiliationsUniversity of Queensland
Montreal Neurological Institute, Canada
Queensland Centre for Mental Health Research, Australia
Department of Health, Queensland
University of Melbourne
Funding source
NHMRC
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