Neurogenesis in adult human

Article


Murrell, Wayne, Ray-Barruel, Gillia, Livesey, Jonathon, McGrath, John, MacDonald, Kelli P. A., Bates, Paul R. and Mackay-Sim, Alan. 1996. "Neurogenesis in adult human ." NeuroReport. 7 (6), pp. 1189-1194. https://doi.org/10.1097/00001756-199604260-00019
Article Title

Neurogenesis in adult human

ERA Journal ID3536
Article CategoryArticle
AuthorsMurrell, Wayne, Ray-Barruel, Gillia, Livesey, Jonathon, McGrath, John, MacDonald, Kelli P. A., Bates, Paul R. and Mackay-Sim, Alan
Journal TitleNeuroReport
Journal Citation7 (6), pp. 1189-1194
Number of Pages6
Year1996
PublisherLippincott Williams & Wilkins
Place of PublicationUnited States
ISSN0959-4965
1473-558X
Digital Object Identifier (DOI)https://doi.org/10.1097/00001756-199604260-00019
Web Address (URL)https://journals.lww.com/neuroreport/Abstract/1996/04260/Neurogenesis_in_adult_human.19.aspx
Abstract

This report describes neurogenesis in the adult human olfactory epithelium in vitro. Olfactory epithelium was collected at autopsy and by biopsy, and grown in serum-free medium. Basic fibroblast growth factor induced the differentiation of bipolar cells which were immunopositive for several neuronal proteins but not glial proteins. [3H]thymidine autoradiography confirmed that these neurones were born in vitro. The results demonstrate that the adult human olfactory epithelium retains the capacity for neurogenesis and neuronal differentiation, at least until the age of 72 years. It is now possible to examine neurones and neurogenesis in biopsies from patients with disorders that may involve a neurodevelopmental or neurodegenerative aetiology such as schizophrenia, bipolar disorder and Alzheimer's disease.

KeywordsAlzheimer's disease; Brain development; Growth factor; Human olfactory mucosa; Neurodevelopmental disorders; Neurogenesis; Schizophrenia
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PubMed ID8817530
Byline AffiliationsGriffith University
Princess Alexandra Hospital, Australia
Wolston Park Hospital, Australia
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