Normal inhibition of DNA synthesis following γ-irradiation of radiosensitive cell lines from patients with Down's syndromes and Alzheimer's disease

Article


Lavin, Martin F., Bates Paul, Le Poidevin, Priscilla and Chen, Philip C.. 1989. "Normal inhibition of DNA synthesis following γ-irradiation of radiosensitive cell lines from patients with Down's syndromes and Alzheimer's disease." Mutation Research/DNA Repair. 218 (1), pp. 41-47. https://doi.org/10.1016/0921-8777(89)90045-1
Article Title

Normal inhibition of DNA synthesis following γ-irradiation of radiosensitive cell lines from patients with Down's syndromes and Alzheimer's disease

Article CategoryArticle
AuthorsLavin, Martin F., Bates Paul, Le Poidevin, Priscilla and Chen, Philip C.
Journal TitleMutation Research/DNA Repair
Journal Citation218 (1), pp. 41-47
Number of Pages7
Year1989
PublisherElsevier
Place of PublicationNetherlands
ISSN0921-8777
1386-1476
Digital Object Identifier (DOI)https://doi.org/10.1016/0921-8777(89)90045-1
Web Address (URL)https://www.sciencedirect.com/science/article/abs/pii/0921877789900451
Abstract

Inhibition of DNA synthesis was studied in γ-irradiated lymphoblastoid cells from patients with Alzheimer's disease and Down's syndrome. A normal biphasic pattern of inhibition was observed over a dose range of 0-4 krad of γ-rays in all of the cell lines. 3 out of 4 Down's and all the Alzheimer's cell lines were shown to be hypersensitive to ionizing radiation based on induced chromosomal aberrations. Increased G2 phase delay, comparable to that occurring in ataxia-telangiectasia cells, was observed for some of the cell lines, after exposure to γ-rays. Contrary to other data in the literature these results demonstrate that radioresistant DNA synthesis is not an intrinsic feature of all disorders characterized by radiosensitivity. © 1989.

KeywordsAlzheimer's diasease; DNA synthesis, inhibition; Down's syndrome; Lymphoblastoid cells, γ-irradiation
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PubMed ID2526297
FunderNational Health and Medical Research Council
Byline AffiliationsQueensland Institute of Medical Research, Australia
Department of Health, Queensland
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