Normal inhibition of DNA synthesis following γ-irradiation of radiosensitive cell lines from patients with Down's syndromes and Alzheimer's disease
Article
Lavin, Martin F., Bates Paul, Le Poidevin, Priscilla and Chen, Philip C.. 1989. "Normal inhibition of DNA synthesis following γ-irradiation of radiosensitive cell lines from patients with Down's syndromes and Alzheimer's disease." Mutation Research/DNA Repair. 218 (1), pp. 41-47. https://doi.org/10.1016/0921-8777(89)90045-1
| Article Title | Normal inhibition of DNA synthesis following γ-irradiation of radiosensitive cell lines from patients with Down's syndromes and Alzheimer's disease |
|---|---|
| Article Category | Article |
| Authors | Lavin, Martin F., Bates Paul, Le Poidevin, Priscilla and Chen, Philip C. |
| Journal Title | Mutation Research/DNA Repair |
| Journal Citation | 218 (1), pp. 41-47 |
| Number of Pages | 7 |
| Year | 1989 |
| Publisher | Elsevier |
| Place of Publication | Netherlands |
| ISSN | 0921-8777 |
| 1386-1476 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1016/0921-8777(89)90045-1 |
| Web Address (URL) | https://www.sciencedirect.com/science/article/abs/pii/0921877789900451 |
| Abstract | Inhibition of DNA synthesis was studied in γ-irradiated lymphoblastoid cells from patients with Alzheimer's disease and Down's syndrome. A normal biphasic pattern of inhibition was observed over a dose range of 0-4 krad of γ-rays in all of the cell lines. 3 out of 4 Down's and all the Alzheimer's cell lines were shown to be hypersensitive to ionizing radiation based on induced chromosomal aberrations. Increased G2 phase delay, comparable to that occurring in ataxia-telangiectasia cells, was observed for some of the cell lines, after exposure to γ-rays. Contrary to other data in the literature these results demonstrate that radioresistant DNA synthesis is not an intrinsic feature of all disorders characterized by radiosensitivity. © 1989. |
| Keywords | Alzheimer's diasease; DNA synthesis, inhibition; Down's syndrome; Lymphoblastoid cells, γ-irradiation |
| Contains Sensitive Content | Does not contain sensitive content |
| Public Notes | There are no files associated with this item. |
| PubMed ID | 2526297 |
| Funder | National Health and Medical Research Council |
| Byline Affiliations | Queensland Institute of Medical Research, Australia |
| Department of Health, Queensland |
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