Normal inhibition of DNA synthesis following γ-irradiation of radiosensitive cell lines from patients with Down's syndromes and Alzheimer's disease
Article
Article Title | Normal inhibition of DNA synthesis following γ-irradiation of radiosensitive cell lines from patients with Down's syndromes and Alzheimer's disease |
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Article Category | Article |
Authors | Lavin, Martin F., Bates Paul, Le Poidevin, Priscilla and Chen, Philip C. |
Journal Title | Mutation Research/DNA Repair |
Journal Citation | 218 (1), pp. 41-47 |
Number of Pages | 7 |
Year | 1989 |
Publisher | Elsevier |
Place of Publication | Netherlands |
ISSN | 0921-8777 |
1386-1476 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/0921-8777(89)90045-1 |
Web Address (URL) | https://www.sciencedirect.com/science/article/abs/pii/0921877789900451 |
Abstract | Inhibition of DNA synthesis was studied in γ-irradiated lymphoblastoid cells from patients with Alzheimer's disease and Down's syndrome. A normal biphasic pattern of inhibition was observed over a dose range of 0-4 krad of γ-rays in all of the cell lines. 3 out of 4 Down's and all the Alzheimer's cell lines were shown to be hypersensitive to ionizing radiation based on induced chromosomal aberrations. Increased G2 phase delay, comparable to that occurring in ataxia-telangiectasia cells, was observed for some of the cell lines, after exposure to γ-rays. Contrary to other data in the literature these results demonstrate that radioresistant DNA synthesis is not an intrinsic feature of all disorders characterized by radiosensitivity. © 1989. |
Keywords | Alzheimer's diasease; DNA synthesis, inhibition; Down's syndrome; Lymphoblastoid cells, γ-irradiation |
Contains Sensitive Content | Does not contain sensitive content |
Public Notes | There are no files associated with this item. |
PubMed ID | 2526297 |
Funder | National Health and Medical Research Council |
Byline Affiliations | Queensland Institute of Medical Research, Australia |
Department of Health, Queensland |
https://research.usq.edu.au/item/yy805/normal-inhibition-of-dna-synthesis-following-irradiation-of-radiosensitive-cell-lines-from-patients-with-down-s-syndromes-and-alzheimer-s-disease
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