Comparison of γ-radiation-induced accumulation of ataxia telangiectasia and control cells in G2 phase
Article
Bates Paul R. and Lavin, Martin F.. 1989. "Comparison of γ-radiation-induced accumulation of ataxia telangiectasia and control cells in G2 phase." Mutation Research/DNA Repair. 218 (2), pp. 165-170. https://doi.org/10.1016/0921-8777(89)90023-2
| Article Title | Comparison of γ-radiation-induced accumulation of ataxia telangiectasia and control cells in G2 phase |
|---|---|
| Article Category | Article |
| Authors | Bates Paul R. and Lavin, Martin F. |
| Journal Title | Mutation Research/DNA Repair |
| Journal Citation | 218 (2), pp. 165-170 |
| Number of Pages | 6 |
| Year | 1989 |
| Publisher | Elsevier |
| Place of Publication | Netherlands |
| ISSN | 0921-8777 |
| 1386-1476 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1016/0921-8777(89)90023-2 |
| Web Address (URL) | https://www.sciencedirect.com/science/article/abs/pii/0921877789900232 |
| Abstract | Recent reports from a number of laboratories have linked radiosensitivity in ataxia telangiectasia (A-T) to a large and prolonged block of some cells in G2 phase. Previous results from this laboratory, largely with one Epstein-Barr virus-transformed A-T lymphoblastoid cell line, presented evidence for a dramatic increase in the number of cells in G2 phase over controls during a 24-h period post irradiation. We describe here a study of the effect of γ-radiation on G2 phase delay in several A-T cell lines. Based on previous results with several cell lines 24 h post irradiation was selected as the optimum time to discriminate between G2 phase delay in control and A-T cells. All A-T homozygotes showed a significantly greater number of cells in G2 phase, 24 h post irradiation, than observed in controls. A more prolonged delay in G2 phase after irradiation was seen in different A-T cell types that included lymphoblastoid cells, fibroblasts and SV40-transformed fibroblasts. At the radiation dose used it was not possible to distinguish A-T heterozygotes from controls. © 1989. |
| Keywords | Ataxia telangiectasia; Flow cytometry; G phase accumulation 2; Ionizing radiation |
| Contains Sensitive Content | Does not contain sensitive content |
| Public Notes | There are no files associated with this item. |
| Byline Affiliations | Department of Health, Queensland |
| Queensland Institute of Medical Research, Australia |
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