Comparison of γ-radiation-induced accumulation of ataxia telangiectasia and control cells in G2 phase

Article


Bates Paul R. and Lavin, Martin F.. 1989. "Comparison of γ-radiation-induced accumulation of ataxia telangiectasia and control cells in G2 phase." Mutation Research/DNA Repair. 218 (2), pp. 165-170. https://doi.org/10.1016/0921-8777(89)90023-2
Article Title

Comparison of γ-radiation-induced accumulation of ataxia telangiectasia and control cells in G2 phase

Article CategoryArticle
AuthorsBates Paul R. and Lavin, Martin F.
Journal TitleMutation Research/DNA Repair
Journal Citation218 (2), pp. 165-170
Number of Pages6
Year1989
PublisherElsevier
Place of PublicationNetherlands
ISSN0921-8777
1386-1476
Digital Object Identifier (DOI)https://doi.org/10.1016/0921-8777(89)90023-2
Web Address (URL)https://www.sciencedirect.com/science/article/abs/pii/0921877789900232
Abstract

Recent reports from a number of laboratories have linked radiosensitivity in ataxia telangiectasia (A-T) to a large and prolonged block of some cells in G2 phase. Previous results from this laboratory, largely with one Epstein-Barr virus-transformed A-T lymphoblastoid cell line, presented evidence for a dramatic increase in the number of cells in G2 phase over controls during a 24-h period post irradiation. We describe here a study of the effect of γ-radiation on G2 phase delay in several A-T cell lines. Based on previous results with several cell lines 24 h post irradiation was selected as the optimum time to discriminate between G2 phase delay in control and A-T cells. All A-T homozygotes showed a significantly greater number of cells in G2 phase, 24 h post irradiation, than observed in controls. A more prolonged delay in G2 phase after irradiation was seen in different A-T cell types that included lymphoblastoid cells, fibroblasts and SV40-transformed fibroblasts. At the radiation dose used it was not possible to distinguish A-T heterozygotes from controls. © 1989.

KeywordsAtaxia telangiectasia; Flow cytometry; G phase accumulation 2; Ionizing radiation
Contains Sensitive ContentDoes not contain sensitive content
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Byline AffiliationsDepartment of Health, Queensland
Queensland Institute of Medical Research, Australia
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