Olfactory glia enhance neonatal axon regeneration

Article

Chehrehasa, Fatemah, Windus, Louisa C. E., Ekberg, Jenny, Scott, Susan, Amaya, Daniel, Mackay-Sim, Alan and St John, James. 2010. "Olfactory glia enhance neonatal axon regeneration." Molecular and Cellular Neuroscience. 45 (3), pp. 277-288. https://doi.org/10.1016/j.mcn.2010.07.002
Article Title

Olfactory glia enhance neonatal axon regeneration

ERA Journal ID14527
Article CategoryArticle
AuthorsChehrehasa, Fatemah (Author), Windus, Louisa C. E. (Author), Ekberg, Jenny (Author), Scott, Susan (Author), Amaya, Daniel (Author), Mackay-Sim, Alan (Author) and St John, James (Author)
Journal TitleMolecular and Cellular Neuroscience
Journal Citation45 (3), pp. 277-288
Number of Pages12
Year2010
Place of PublicationUnited States
ISSN1044-7431
1095-9327
Digital Object Identifier (DOI)https://doi.org/10.1016/j.mcn.2010.07.002
Web Address (URL)https://www.sciencedirect.com/science/article/abs/pii/S1044743110001521
Abstract

Olfactory ensheathing cells (OECs) migrate with olfactory axons that extend from the nasal epithelium into the olfactory bulb. Unlike other glia, OECs are thought to migrate ahead of growing axons instead of following defined axonal paths. However it remains unknown how the presence of axons and OECs influences the growth and migration of each other during regeneration. We have developed a regeneration model in neonatal mice to examine whether (i) the presence of OECs ahead of olfactory axons affects axonal growth and (ii) the presence of olfactory axons alters the distribution of OECs. We performed unilateral bulbectomy to ablate olfactory axons followed by methimazole administration to further delay neuronal growth. In this model OECs filled the cavity left by the bulbectomy before new axons extended into the cavity. We found that delaying axon growth increased the rate at which OECs filled the cavity. The axons subsequently grew over a significantly larger region and formed more distinct fascicles and glomeruli in comparison with growth in animals that had undergone only bulbectomy. In vitro, we confirmed (i) that olfactory axon growth was more rapid when OECs were more widely distributed than the axons and (ii) that OECs migrated faster in the absence of axons. These results demonstrate that the distribution of OECs can be increased by repressing by growth of olfactory axons and that olfactory axon growth is significantly enhanced if a permissive OEC environment is present prior to axon growth.

KeywordsGlia; Olfactory bulb; Methimazole; Bulbectomy; Neuron; Fascicle
ANZSRC Field of Research 2020310105. Cellular interactions (incl. adhesion, matrix, cell wall)
310102. Cell development, proliferation and death
Byline AffiliationsGriffith University
Institution of OriginUniversity of Southern Queensland
Funding source
NHMRC
Permalink -

https://research.usq.edu.au/item/q5z2z/olfactory-glia-enhance-neonatal-axon-regeneration

Log in to edit
  • 117
    total views
  • 10
    total downloads
  • 4
    views this month
  • 0
    downloads this month

Export as

Related outputs

A low-cost, antimicrobial aloe-alginate hydrogel film containing Australian First Nations remedy ‘lemon myrtle oil’ (Backhousia citriodora) – Potential for incorporation into wound dressings
Seneviratne, Dinuki M., Raphael, Brooke, Whiteside, Eliza J., Windus, Louisa C.E., Kauter, Kate, Dearnaley, John D.W., Annamalai, Pratheep K., Ward, Raelene, Song, Pingan and Burey, Paulomi (Polly). 2024. " A low-cost, antimicrobial aloe-alginate hydrogel film containing Australian First Nations remedy ‘lemon myrtle oil’ (Backhousia citriodora) – Potential for incorporation into wound dressings." Heliyon. 10 (18). https://doi.org/10.1016/j.heliyon.2024.e37516
The advantages of microneedle patches compared to conventional needle-based drug delivery and biopsy devices in medicine
Reinke, Alissa, Whiteside, Eliza J, Windus, Louisa, Desai, Devang, Stehr, Emma and Faraji Rad, Zahra. 2024. "The advantages of microneedle patches compared to conventional needle-based drug delivery and biopsy devices in medicine." Biomedical Engineering Advances. 8. https://doi.org/10.1016/j.bea.2024.100127
Induction of Reactive Bone Stromal Fibroblasts in 3D Models of Prostate Cancer Bone Metastases
Windus, Louisa C. E., Matigian, Nicholas and Avery, Vicky M.. 2023. "Induction of Reactive Bone Stromal Fibroblasts in 3D Models of Prostate Cancer Bone Metastases." Biology. 12 (6). https://doi.org/10.3390/biology12060861
Fundamentals of Anatomy and Physiology
Chruscik, Anna, Kauter, Kate, Windus, Louisa, Whiteside, Eliza and Dooley, Leanne. 2021. Fundamentals of Anatomy and Physiology . Australia. University of Southern Queensland.
HearNPV susceptibility in Helicoverpa armigera and Helicoverpa punctigera strains resistant to Bt toxins Cry1Ac, Cry2Ab, and Vip3Aa
Windus, Louisa C.E., Jones, Adele M., Downes, Sharon, Walsh, Tom, Kinkema, Mark and Knight, Kristen. 2021. "HearNPV susceptibility in Helicoverpa armigera and Helicoverpa punctigera strains resistant to Bt toxins Cry1Ac, Cry2Ab, and Vip3Aa." Journal of Invertebrate Pathology. 183, pp. 1-8. https://doi.org/10.1016/j.jip.2021.107598
The impact of an anatomy and physiology open textbook on student satisfaction and engagement in a regional Australian university
Chruscik, Anna, Kauter, Kate, Whiteside, Anna and Windus, Louisa. 2022. "The impact of an anatomy and physiology open textbook on student satisfaction and engagement in a regional Australian university." 39th International Conference on Innovation, Practice and Research in the Use of Educational Technologies in Tertiary Education (ASCILITE 2022). Sydney, Australia 04 - 07 Dec 2022 Australia. Australasian Society for Computers in Learning in Tertiary Education (ASCILITE). https://doi.org/10.14742/APUBS.2022.183
How to do science: A guide to researching human physiology
Lexis, Louise, Julien, Brianna, Bliss, Edward, Derrington, Kate, Dooley, Leanne, Kauter, Kate, McGregor, Rowena, Myer, Sarah, Salmeron, Raquel, Suraweera, Samanthi, Whiteside, Eliza and Windus, Louisa. 2022. How to do science: A guide to researching human physiology. Australia. University of Southern Queensland.
Regulation of the chemokine receptors CXCR7 and CXCR4 in 3-D culture models of prostate cancer
Kiss, Debra L., Windus, Louisa C. E. and Avery, Vickey M.. 2012. "Regulation of the chemokine receptors CXCR7 and CXCR4 in 3-D culture models of prostate cancer." 2012 AACR Special Conference on Advances in Prostate Cancer Research. Orlando, United States of America 06 - 09 Feb 2012 United States. https://doi.org/10.1158/1538-7445
Academic achievement and student satisfaction: moving anatomy and physiology teaching online
Chruscik, Anna, Windus, Louisa, Wang, Jianxiong, Kauter, Kate and Whiteside, Eliza. 2020. "Academic achievement and student satisfaction: moving anatomy and physiology teaching online." 2020 Australian Conference on Science and Mathematics Education (formerly UniServe Science Conference). Online 30 Sep - 02 Oct 2020 Australia.
Chemokine receptor expression on integrin-mediated stellate projections of prostate cancer cells in 3D culture
Kiss, Debra, Windus, Louisa C. E. and Avery, Vicky. 2013. "Chemokine receptor expression on integrin-mediated stellate projections of prostate cancer cells in 3D culture." Cytokine. 64 (1), pp. 122-130. https://doi.org/10.1016/j.cyto.2013.07.012
Bone-stromal cells up-regulate tumourigenic markers in a tumour-stromal 3D model of prostate cancer
Windus, Louisa C. E., Glover, Tristan T. and Avery, V.. 2013. "Bone-stromal cells up-regulate tumourigenic markers in a tumour-stromal 3D model of prostate cancer." Molecular Cancer. 12, pp. 1-19. https://doi.org/10.1186/1476-4598-12-112
PCaAnalyser: A 2D-Image Analysis Based Module for Effective Determination of Prostate Cancer Progression in 3D Culture
Hoque, Md Tamjidul, Windus, Louisa C. E., Lovitt, Carrie J. and Avery, Vicky. 2013. "PCaAnalyser: A 2D-Image Analysis Based Module for Effective Determination of Prostate Cancer Progression in 3D Culture." PLoS One. 8 (11), pp. 1-13. https://doi.org/10.1371/journal.pone.0079865
In vivo biomarker expression patterns are preserved in 3D cultures of Prostate Cancer
Windus, Louisa C. E., Kiss, Debra L., Glover, Tristan T. and Avery, Vicky M.. 2012. "In vivo biomarker expression patterns are preserved in 3D cultures of Prostate Cancer." Experimental Cell Research. 318 (19), pp. 2507-2519. https://doi.org/10.1016/j.yexcr.2012.07.013
Correction of aberrant axon growth in the developing mouse olfactory bulb
Chan, C., Ekberg, J., Lineburg, K., Scott, S., Chehrehasa, F., Windus, L., Claxton, C., Mackay-Sim, A., Key, B. and St John, J.. 2011. "Correction of aberrant axon growth in the developing mouse olfactory bulb." Molecular and Cellular Neuroscience. 46 (1), pp. 282-295. https://doi.org/10.1016/j.mcn.2010.09.012
OMP-ZsGreen fluorescent protein transgenic mice for visualisation of olfactory sensory neurons in vivo and in vitro
Ekberg, J., Amaya, D., Chehrehasa, F., Lineburg, K., Claxton, C., Windus, Louisa C. E., Key, B., Mackay-Sim, A. and St John, J.. 2011. "OMP-ZsGreen fluorescent protein transgenic mice for visualisation of olfactory sensory neurons in vivo and in vitro." Journal of Neuroscience Methods. 196 (1), pp. 88-98. https://doi.org/10.1016/j.jneumeth.2011.01.008
Stimulation of olfactory ensheathing cell motility enhances olfactory axon growth
Windus, Louisa C. E., Chehrehasa, Fatemah, Lineburg, Katie, Claxton, Christina, Mackay-Sim, Alan, Key, Brian and St John, James. 2011. "Stimulation of olfactory ensheathing cell motility enhances olfactory axon growth." Cellular and Molecular Life Sciences. 68 (19), pp. 3233-3247. https://doi.org/10.1007/s00018-011-0630-9
Copper, Nickel, and Zinc Cyclam−Amino Acid and Cyclam−Peptide Complexes May Be Synthesized with 'Click' Chemistry and Are Noncytotoxic
Yu, Mingfeng, Price, Jason, Jensen, Paul D., Lovitt, Carrie J., Shelper, Todd, Duffy, Sandra, Windus, Louisa C., Avery, Vicky, Rutledge, Peter and Todd, Matthew. 2011. "Copper, Nickel, and Zinc Cyclam−Amino Acid and Cyclam−Peptide Complexes May Be Synthesized with 'Click' Chemistry and Are Noncytotoxic." Inorganic Chemistry: including bioinorganic chemistry. 50, pp. 12823-12835. https://doi.org/10.1021/ic2020012
Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions
Windus, Louisa C. E., Lineburg, Katie, Scott, Susan, Claxton, Christina, Mackay-Sim, Alan, Key, Brian and St John, James. 2010. "Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions." Cellular and Molecular Life Sciences. 67 (10), pp. 1735-1750. https://doi.org/10.1007/s00018-010-0280-3
Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia
Windus, Louisa C. E., Claxton, C., Allen, C., Key, B. and St John, J.. 2007. "Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia." Glia. 55 (15), pp. 1708-1719. https://doi.org/10.1002/glia.20586
Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
Matigan, N., Windus, L., Smith, H., Filippich, C., Pantelis, C., McGrath, J., Mowry, B. and Hayward, N.. 2007. "Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway." Molecular Psychiatry. 12 (9), pp. 815-825. https://doi.org/10.1038/sj.mp.4001998
Evidence of altered prefrontal–thalamic circuitry in schizophrenia: An optimized diffusion MRI study
Rose, S., Chalk, J., Janke, A., Strudwick, M., Windus, Louisa C., Hannah, D., McGrath, J., Pantelis, C., Wood, S. and Mowry, B.. 2006. "Evidence of altered prefrontal–thalamic circuitry in schizophrenia: An optimized diffusion MRI study." NeuroImage. 32 (1), pp. 16-22. https://doi.org/10.1016/j.neuroimage.2006.03.003
Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia
Handoko, HY, Nyholt, DR, Hayward, NK, Nertney, DA, Hannah, DE, Windus, LC, McCormack, CM, Smith, HJ, Flippich, C, James, MR and Mowry, BJ. 2004. "Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia." Molecular Psychiatry. 10 (6), pp. 589-597. https://doi.org/10.1038/sj.mp.4001606
Neurogenesis in adult human
Murrell, Wayne, Ray-Barruel, Gillia, Livesey, Jonathon, McGrath, John, MacDonald, Kelli P. A., Bates, Paul R. and Mackay-Sim, Alan. 1996. "Neurogenesis in adult human ." NeuroReport. 7 (6), pp. 1189-1194. https://doi.org/10.1097/00001756-199604260-00019