The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea

Poster


Mills, Dean, Johnson, Michael, McPhilimey, Martin, Williams, Neil, Gonzalez, Javier, Barnett, Yvonne and Sharpe, Graham. 2012. "The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
Paper/Presentation Title

The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea

Presentation TypePoster
AuthorsMills, Dean (Author), Johnson, Michael (Author), McPhilimey, Martin (Author), Williams, Neil (Author), Gonzalez, Javier (Author), Barnett, Yvonne (Author) and Sharpe, Graham (Author)
Journal or Proceedings TitleEuropean Respiratory Journal
Journal Citation40 (56 (Supplement)), p. 2357
Number of Pages1
Year2012
Place of PublicationSwitzerland
ISSN0903-1936
1399-3003
Web Address (URL) of Paperhttp://erj.ersjournals.com/content/erj/40/Suppl_56/P2357.full.pdf
Conference/Event22nd European Respiratory Society Annual Congress
Event Details
22nd European Respiratory Society Annual Congress
Event Date
01 to end of 05 Sep 2012
Event Location
Vienna, Austria
Abstract

Vassilakopoulos et al. (Am. J. Physiol 1999; 277:R1013–R1019) demonstrated a breathing-induced interleukin-6 (IL-6) response. Whether inspiratory muscle training (IMT) can attenuate this response is unknown. Therefore, we tested the hypothesis that the IL-6 response to volitional hyperpnoea (VH) could be reduced with IMT and investigated whether this response was related to diaphragm fatigue (assessed by phrenic nerve stimulation) and/or changes in blood lactate concentration ([Lac-]B).

Twelve male participants performed either 6 weeks of pressure-threshold IMT (n=6) or placebo (PLA) training (n=6). Prior to training, a maximal incremental cycling test (max) was performed. Before and after training, participants undertook two 1 h experimental trials on separate days: passive rest or VH. In VH, they voluntarily mimicked at rest the breathing and respiratory muscle recruitment pattern equal to 70-80% of the maximum minute ventilation achieved during max.

IL-6 increased (P<0.01) following the pre-training VH and was (mean ± SD) 5.02 ± 0.63 and 4.87 ± 0.86 pg·mL-1 at 2 h post for IMT and PLA groups, respectively. [Lac-]B remained (P<0.01) elevated above baseline values for the duration of VH at 1.36 ± 0.24 and 1.29 ± 0.18 mmol⋅L-1. The IL-6 (-29%) and [Lac-]B (-11%) responses were reduced (P<0.05) for the IMT, but not for the PLA group. There were no increases in IL-6 or [Lac-]B over time for either group during passive rest and no evidence of diaphragm fatigue during any trial.

In conclusion, 6 weeks of IMT reduces the magnitude of the IL-6 response to VH with no evidence of diaphragm fatigue. The reduction in IL-6 may be related to the post-IMT reduction in [Lac-]B.

Keywordsimmunology; anti-inflammatory; respiratory muscle
ANZSRC Field of Research 2020420702. Exercise physiology
Public Notes

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Byline AffiliationsNottingham Trent University, United Kingdom
South Warwickshire University NHS Trust, United Kingdom
Northumbria University, United Kingdom
Institution of OriginUniversity of Southern Queensland
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