Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation

Article

Mills, Dean E., Johnson, Michael A., McPhilimey, Martin J., Williams, Neil C., Gonzalez, Javier T., Barnett, Yvonne A. and Sharpe, Graham R.. 2014. "Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation." Journal of Applied Physiology. 116 (8), pp. 970-979. https://doi.org/10.1152/japplphysiol.01271.2013
Article Title

Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation

ERA Journal ID3161
Article CategoryArticle
AuthorsMills, Dean E. (Author), Johnson, Michael A. (Author), McPhilimey, Martin J. (Author), Williams, Neil C. (Author), Gonzalez, Javier T. (Author), Barnett, Yvonne A. (Author) and Sharpe, Graham R. (Author)
Journal TitleJournal of Applied Physiology
Journal Citation116 (8), pp. 970-979
Number of Pages10
Year2014
PublisherAmerican Physiological Society
Place of PublicationUnited States
ISSN1522-1601
8750-7587
Digital Object Identifier (DOI)https://doi.org/10.1152/japplphysiol.01271.2013
Web Address (URL)https://journals.physiology.org/doi/full/10.1152/japplphysiol.01271.2013
Abstract

The influence of oxidative stress, diaphragm fatigue, and inspiratory muscle training (IMT) on the cytokine response to maximum sustainable voluntary ventilation (MSVV) is unknown. Twelve healthy males were divided equally into an IMT or placebo (PLA) group, and before and after a 6-wk intervention they undertook, on separate days, 1 h of (1) passive rest and (2) MSVV, whereby participants undertook volitional hyperpnea at rest that mimicked the breathing and respiratory muscle recruitment patterns commensurate with heavy cycling exercise. Plasma cytokines remained unchanged during passive rest. There was a main effect of time (P <0.01) for plasma interleukin-1β (IL-1β) and interleukin-6 (IL-6) concentrations and a strong trend (P = 0.067) for plasma interleukin-1 receptor antagonist concentration during MSVV. Plasma IL-6 concentration was reduced after IMT by 27 ± 18% (main effect of intervention, P = 0.029), whereas there was no change after PLA (P = 0.753). There was no increase in a systemic marker of oxidative stress [DNA damage in peripheral blood mononuclear cells (PBMC)], and diaphragm fatigue was not related to the increases in plasma IL-1β and IL-6 concentrations. A dose-response relationship was observed between respiratory muscle work and minute ventilation and increases in plasma IL-6 concentration. In conclusion, increases in plasma IL-1β and IL-6 concentrations during MSVV were not due to diaphragm fatigue or DNA damage in PBMC. Increases in plasma IL-6 concentration during MSVV are attenuated following IMT, and the plasma IL-6 response is dependent upon the level of respiratory muscle work and minute ventilation.

ANZSRC Field of Research 2020420702. Exercise physiology
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Byline AffiliationsNottingham Trent University, United Kingdom
Northumbria University, United Kingdom
Institution of OriginUniversity of Southern Queensland
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