Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation

Article

Mills, Dean E., Johnson, Michael A., McPhilimey, Martin J., Williams, Neil C., Gonzalez, Javier T., Barnett, Yvonne A. and Sharpe, Graham R.. 2014. "Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation." Journal of Applied Physiology. 116 (8), pp. 970-979. https://doi.org/10.1152/japplphysiol.01271.2013
Article Title

Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation

ERA Journal ID3161
Article CategoryArticle
AuthorsMills, Dean E. (Author), Johnson, Michael A. (Author), McPhilimey, Martin J. (Author), Williams, Neil C. (Author), Gonzalez, Javier T. (Author), Barnett, Yvonne A. (Author) and Sharpe, Graham R. (Author)
Journal TitleJournal of Applied Physiology
Journal Citation116 (8), pp. 970-979
Number of Pages10
Year2014
PublisherAmerican Physiological Society
Place of PublicationUnited States
ISSN1522-1601
8750-7587
Digital Object Identifier (DOI)https://doi.org/10.1152/japplphysiol.01271.2013
Web Address (URL)https://journals.physiology.org/doi/full/10.1152/japplphysiol.01271.2013
Abstract

The influence of oxidative stress, diaphragm fatigue, and inspiratory muscle training (IMT) on the cytokine response to maximum sustainable voluntary ventilation (MSVV) is unknown. Twelve healthy males were divided equally into an IMT or placebo (PLA) group, and before and after a 6-wk intervention they undertook, on separate days, 1 h of (1) passive rest and (2) MSVV, whereby participants undertook volitional hyperpnea at rest that mimicked the breathing and respiratory muscle recruitment patterns commensurate with heavy cycling exercise. Plasma cytokines remained unchanged during passive rest. There was a main effect of time (P <0.01) for plasma interleukin-1β (IL-1β) and interleukin-6 (IL-6) concentrations and a strong trend (P = 0.067) for plasma interleukin-1 receptor antagonist concentration during MSVV. Plasma IL-6 concentration was reduced after IMT by 27 ± 18% (main effect of intervention, P = 0.029), whereas there was no change after PLA (P = 0.753). There was no increase in a systemic marker of oxidative stress [DNA damage in peripheral blood mononuclear cells (PBMC)], and diaphragm fatigue was not related to the increases in plasma IL-1β and IL-6 concentrations. A dose-response relationship was observed between respiratory muscle work and minute ventilation and increases in plasma IL-6 concentration. In conclusion, increases in plasma IL-1β and IL-6 concentrations during MSVV were not due to diaphragm fatigue or DNA damage in PBMC. Increases in plasma IL-6 concentration during MSVV are attenuated following IMT, and the plasma IL-6 response is dependent upon the level of respiratory muscle work and minute ventilation.

ANZSRC Field of Research 2020420702. Exercise physiology
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsNottingham Trent University, United Kingdom
Northumbria University, United Kingdom
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q35q7/influence-of-oxidative-stress-diaphragm-fatigue-and-inspiratory-muscle-training-on-the-plasma-cytokine-response-to-maximum-sustainable-voluntary-ventilation

Log in to edit
  • 1669
    total views
  • 8
    total downloads
  • 2
    views this month
  • 0
    downloads this month

Export as

Related outputs

The effects of inspiratory muscle training on biomarkers of muscle damage in recovered COVID-19 patients after weaning from mechanical ventilation
Iqbal, Muneeb, Hassan, Kumail, Bliss, Edward, Whiteside, Eliza J, Hoffman, Ben and Mills, Dean E. 2024. "The effects of inspiratory muscle training on biomarkers of muscle damage in recovered COVID-19 patients after weaning from mechanical ventilation." Chronic Respiratory Disease. 21. https://doi.org/10.1177/14799731241289423
Exercise to combat cancer focusing on the ends
Denham, Joshua, Bliss, Edward S., Bryan, Tracy M., O'Brien, Brendan J. and Mills, Dean. 2024. "Exercise to combat cancer focusing on the ends." Physiological Genomics. https://doi.org/10.1152/physiolgenomics.00075.2024
The impact of lipopolysaccharide on cerebrovascular function and cognition resulting from obesity-induced gut dysbiosis
Thornton, Tammy, Mills, Dean and Bliss, Edward. 2024. "The impact of lipopolysaccharide on cerebrovascular function and cognition resulting from obesity-induced gut dysbiosis." Life Sciences. 336. https://doi.org/10.1016/j.lfs.2023.122337
Differences in total cognition and cerebrovascular function in female breast cancer survivors and cancer-free women
Downs, Tahnee L., Whiteside, Eliza J., Foot, Gaye, Mills, Dean E. and Bliss, Edward S.. 2023. "Differences in total cognition and cerebrovascular function in female breast cancer survivors and cancer-free women." The Breast. 69, pp. 358-365. https://doi.org/10.1016/j.breast.2023.03.018
Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing
Thornton, Tammy, Mills, Dean and Bliss, Edward. 2023. "Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing ." Nutrients. 15 (6). https://doi.org/10.3390/nu15061537
Facile Fabrication of “Tacky”, Stretchable, and Aligned Carbon Nanotube Sheet-Based Electronics for On-Skin Health Monitoring
Nguyen, Duy Van, Mills, Dean, Tran, Canh-Dung, Nguyen, Thanh, Nguyen, Hung, Tran (Student), Thi Lap, Song, Pingan, Phan, Hoang-Phuong, Nguyen, Nam-Trung, Dao, Dzung Viet, Bell, John and Dinh, Toan. 2023. "Facile Fabrication of “Tacky”, Stretchable, and Aligned Carbon Nanotube Sheet-Based Electronics for On-Skin Health Monitoring ." ACS Applied Materials and Interfaces. 15 (50), p. 58746–58760. https://doi.org/10.1021/acsami.3c13541
The benefits of regular aerobic exercise training on cerebrovascular function and cognition in older adults
Bliss, Edward S., Biki, Samia M., Wong, Rachel H. X., Howe, Peter R. C. and Mills, Dean E.. 2023. "The benefits of regular aerobic exercise training on cerebrovascular function and cognition in older adults." European Journal of Applied Physiology. 123 (6), pp. 1323-1342. https://doi.org/10.1007/s00421-023-05154-y
A student-run exercise physiology clinic in Australia: who and what do we see?
Hume, E., Cameron, M., Findley, I., Smart, S., Elisaia, C., Hulme, A., Mills, D. and Denham, J.. 2023. "A student-run exercise physiology clinic in Australia: who and what do we see? " 2023 ASICS SMA Conference (ASICS SMA 2023). Sunshine Coast, Australia 11 - 14 Oct 2023 Australia. Elsevier. https://doi.org/10.1016/j.jsams.2023.08.107
The effects of age on dyspnea and respiratory mechanical and neural responses to exercise in healthy men
MacAskill, William, Hoffman, Ben, Johnson, Michael A., Sharpe, Graham R., Rands, Joshua, Wotherspoon, Shoena E., Gevorkov, Yaroslav, Kolbe-Alexander, Tracy L. and Mills, Dean E.. 2023. "The effects of age on dyspnea and respiratory mechanical and neural responses to exercise in healthy men." Physiological Reports. 11 (16). https://doi.org/10.14814/phy2.15794
Biomarkers to measure respiratory muscle damage following inspiratory pressure threshold loading in healthy young men
Iqbal, Muneeb, Bliss, Edward, Whiteside, Eliza, Hoffman, Ben and Mills, Dean E,. 2023. "Biomarkers to measure respiratory muscle damage following inspiratory pressure threshold loading in healthy young men." Journal of Applied Physiology. 134 (4), pp. 1038-1046. https://doi.org/10.1152/japplphysiol.00656.2022
The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults
Bliss, Edward S., Wong, Rachel W. X., Howe, Peter R. C. and Mills, Dean E.. 2022. "The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults." Frontiers in Aging Neuroscience. 14, pp. 1-15. https://doi.org/10.3389/fnagi.2022.892343
The Effects Of Age On Exercise-induced Abdominal Muscle Fatigue In Healthy Younger And Older Men
Mills, Dean, Hoffman, Ben, Johnson, Michael A., Sharpe, Graham R., Rands, Joshua, Wotherspoon, Shoena E, Gevorkov, Yaroslav, Kolbe-Alexander, Tracy and MacAskill, William. 2022. "The Effects Of Age On Exercise-induced Abdominal Muscle Fatigue In Healthy Younger And Older Men." Medicine and Science in Sports and Exercise. 54 (9S), pp. 539-239. https://doi.org/10.1249/01.mss.0000881828.14030.71
Beyond criticism of ethics review boards: strategies for engaging research communities and enhancing ethical review processes
Hickey, Andrew, Davis, Samantha, Farmer, Will, Dawidowicz, Julianna, Moloney, Clint, Lamont-Mills, Andrea, Carniel, Jess, Pillay, Yosheen, Akenson, David, Bromdal, Annette, Gehrmann, Richard, Mills, Dean, Kolbe-Alexander, Tracy, Machin, Tanya, Reich, Suzanne, Southey, Kim, Crowley-Cyr, Lynda, Watanabe, Taiji, Davenport, Josh, ..., Maxwell, Jacinta. 2021. "Beyond criticism of ethics review boards: strategies for engaging research communities and enhancing ethical review processes." Journal of Academic Ethics. 20, pp. 549-567. https://doi.org/10.1007/s10805-021-09430-4
The control of respiratory pressures and neuromuscular activation to increase force production in trained martial arts practitioners
Walters, Sherrilyn, Hoffman, Ben, MacAskill, William, Johnson, Michael A., Sharpe, Graham R. and Mills, Dean E.. 2021. "The control of respiratory pressures and neuromuscular activation to increase force production in trained martial arts practitioners." European Journal of Applied Physiology. 121 (12), pp. 3333-3347. https://doi.org/10.1007/s00421-021-04800-7
Pressure measurement characteristics of a micro‐transducer and balloon catheters
MacAskill, William, Hoffman, Ben, Johnson, Michael A., Sharpe, Graham R. and Mills, Dean E.. 2021. "Pressure measurement characteristics of a micro‐transducer and balloon catheters." Physiological Reports. 9 (8). https://doi.org/10.14814/phy2.14831
Benefits of exercise training on cerebrovascular and cognitive function in ageing
Bliss, Edward S., Wong, Rachel H. X., Howe, Peter R. C. and Mills, Dean E.. 2021. "Benefits of exercise training on cerebrovascular and cognitive function in ageing." Journal of Cerebral Blood Flow and Metabolism. 41 (3), pp. 447-470. https://doi.org/10.1177/0271678X20957807
Comparing response, relaxation and measurement characteristics of balloon versus micro pressure transducer catheters
MacAskill, William, Hoffman, Ben, Sharpe, Graham, Johnson, Michael and Mills, Dean. 2019. "Comparing response, relaxation and measurement characteristics of balloon versus micro pressure transducer catheters." European Respiratory Society International Congress 2019. Madrid, Spain 28 Sep - 02 Oct 2019 Sheffield, United Kingdom. https://doi.org/10.1183/13993003.congress-2019.PA752
In vivo characteristics of respiratory neuromuscular responses with balloon catheters and skin surface EMG versus a micro transducer catheter integrated with EMG electrodes
MacAskill, William, Hoffman, Ben, Sharpe, Graham, Johnson, Michael and Mills, Dean. 2019. "In vivo characteristics of respiratory neuromuscular responses with balloon catheters and skin surface EMG versus a micro transducer catheter integrated with EMG electrodes." European Respiratory Society International Congress 2019. Madrid, Spain 28 Sep - 02 Oct 2019 Sheffield, United Kingdom. https://doi.org/10.1183/13993003.congress-2019.PA761
Inspiratory flow-resistive breathing, respiratory muscle-induced systemic oxidative stress, and diaphragm fatigue in healthy humans
Briskey, David R., Vogel, Kurt, Johnson, Michael A., Sharpe, Graham R., Coombes, Jeff S. and Mills, Dean E.. 2020. "Inspiratory flow-resistive breathing, respiratory muscle-induced systemic oxidative stress, and diaphragm fatigue in healthy humans." Journal of Applied Physiology. 129 (1), pp. 185-193. https://doi.org/10.1152/japplphysiol.00091.2020
The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study
Mallard, Alistair, Briskey, David, Richards, Andrew, Mills, Dean and Rao, Amanda. 2020. "The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study." Nutrients. 12 (3), pp. 1-13. https://doi.org/10.3390/nu12030596
Oxygen supplementation for preventing adverse outcomes following surgery or invasive procedures
Eager, Amanda, Ralph, Nicholas, Duff, Jed, Conway, Aaron and Mills, Dean. 2017. "Oxygen supplementation for preventing adverse outcomes following surgery or invasive procedures." PROSPERO: International Prospective Register of Systematic Reviews. 16 June 2017.
Inspiratory muscle warm-up does not improve cycling time trial performance
Gregson, Ian, Mills, Dean, Gonzalez, Javier, Sharpe, Graham and Johnson, Michael. 2012. "Inspiratory muscle warm-up does not improve cycling time trial performance." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
The effects of pressure-threshold inspiratory load on lactate clearance after maximal exercise
Johnson, Michael, Brown, David, Bayfield, Katie, Gonzalez, Javier, Mills, Dean and Sharpe, Graham. 2011. "The effects of pressure-threshold inspiratory load on lactate clearance after maximal exercise." 21st European Respiratory Society Annual Congress. Amsterdam, Netherlands 24 - 28 Sep 2011 Switzerland.
The effects of inspiratory muscle training on breathing mechanics during fixed load cycling exercise
Mills, Dean, Sharpe, Graham, Johnson, Michael and Barnett, Yvonne. 2011. "The effects of inspiratory muscle training on breathing mechanics during fixed load cycling exercise." 21st European Respiratory Society Annual Congress. Amsterdam, Netherlands 24 - 28 Sep 2011 Switzerland.
The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea
Mills, Dean, Johnson, Michael, McPhilimey, Martin, Williams, Neil, Gonzalez, Javier, Barnett, Yvonne and Sharpe, Graham. 2012. "The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea
Mills, Dean, Johnson, Michael, McPhilimey, Martin, Williams, Neil, Gonzalez, Javier, Barnett, Yvonne and Sharpe, Graham. 2012. "The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
Inspiratory loading intensity does not influence lactate clearance during recovery
Johnson, Michael A., Mills, Dean E., Brown, David M., Bayfield, Katie J., Gonzalez, Javier T. and Sharpe, Graham R.. 2012. "Inspiratory loading intensity does not influence lactate clearance during recovery." Medicine and Science in Sports and Exercise. 44 (5), pp. 863-871. https://doi.org/10.1249/MSS.0b013e31824079d0
Prior upper body exercise reduces cycling work capacity but not critical power
Johnson, Michael A., Mills, Dean E., Brown, Peter I. and Sharpe, Graham R.. 2014. "Prior upper body exercise reduces cycling work capacity but not critical power." Medicine and Science in Sports and Exercise. 46 (4), pp. 802-808. https://doi.org/10.1249/MSS.0000000000000159
The effects of inspiratory muscle training on plasma interleukin-6 concentration during cycling exercise and a volitional mimic of the exercise hyperpnea
Mills, Dean E., Johnson, Michael A., McPhilimey, Martin J., Williams, Neil C., Gonzalez, Javier T., Barnett, Yvonne A. and Sharpe, Graham R.. 2013. "The effects of inspiratory muscle training on plasma interleukin-6 concentration during cycling exercise and a volitional mimic of the exercise hyperpnea." Journal of Applied Physiology. 115 (8), pp. 1163-1172. https://doi.org/10.1152/japplphysiol.00272.2013
Response [to the Chiappa et al letter to the editor]
Johnson, Michael A., Mills, Dean E., Brown, Peter I. and Sharpe, Graham R.. 2013. "Response [to the Chiappa et al letter to the editor]." Medicine and Science in Sports and Exercise. 45 (1), pp. 214-215. https://doi.org/10.1249/MSS.0b013e31826aade2
Inspiratory muscle warm-up does not improve cycling time-trial performance
Johnson, M. A., Gregson, I. R., Mills, D. E., Gonzalez, J. T. and Sharpe, G. R.. 2014. "Inspiratory muscle warm-up does not improve cycling time-trial performance." European Journal of Applied Physiology. 114 (9), pp. 1821-1830. https://doi.org/10.1007/s00421-014-2914-x
The effects of inspiratory muscle training in older adults
Mills, Dean E., Johnson, Michael A., Barnett, Yvonne A., Smith, William H. T. and Sharpe, Graham R.. 2015. "The effects of inspiratory muscle training in older adults." Medicine and Science in Sports and Exercise. 47 (4), pp. 691-697. https://doi.org/10.1249/MSS.0000000000000474