The effects of inspiratory muscle training in older adults

Article


Mills, Dean E., Johnson, Michael A., Barnett, Yvonne A., Smith, William H. T. and Sharpe, Graham R.. 2015. "The effects of inspiratory muscle training in older adults." Medicine and Science in Sports and Exercise. 47 (4), pp. 691-697. https://doi.org/10.1249/MSS.0000000000000474
Article Title

The effects of inspiratory muscle training in older adults

ERA Journal ID9788
Article CategoryArticle
AuthorsMills, Dean E. (Author), Johnson, Michael A. (Author), Barnett, Yvonne A. (Author), Smith, William H. T. (Author) and Sharpe, Graham R. (Author)
Journal TitleMedicine and Science in Sports and Exercise
Journal Citation47 (4), pp. 691-697
Number of Pages7
Year2015
PublisherLippincott Williams & Wilkins
Place of PublicationUnited States
ISSN0195-9131
1530-0315
Digital Object Identifier (DOI)https://doi.org/10.1249/MSS.0000000000000474
Web Address (URL)https://journals.lww.com/acsm-msse/Fulltext/2015/04000/The_Effects_of_Inspiratory_Muscle_Training_in.3.aspx
Abstract

Purpose: Declining inspiratory muscle function and structure
and systemic low-level inflammation and oxidative stress may contribute to morbidity and mortality during normal ageing. Therefore, we examined the effects of inspiratory muscle training (IMT) in older adults on inspiratory muscle function and structure and systemic inflammation and oxidative stress, and reexamined the reported positive effects of IMT on respiratory muscle strength, inspiratory
muscle endurance, spirometry, exercise performance, physical activity levels (PAL), and quality of life (QoL).

Methods: Thirty-four healthy older adults (68 ± 3 yr) with normal spirometry, respiratory muscle strength, and physical fitness were divided equally into a pressure-threshold IMT or sham-hypoxic placebo group. Before and after an 8-wk intervention, measurements were taken for dynamic inspiratory muscle function and inspiratory muscle endurance using a weighted plunger pressure-threshold loading device; diaphragm thickness by using B-mode ultrasonography; plasma cytokine concentrations by using immunoassays; DNA damage levels in peripheral
blood mononuclear cells by using comet assays; spirometry, maximal mouth pressures, and exercise performance by using a 6-min walk test; PAL by using a questionnaire and accelerometry; and QoL using a questionnaire.

Results: Compared with placebo, IMT increased maximal inspiratory pressure (+34% ± 43%, P = 0.008), diaphragm thickness at residual volume (+38% ± 39%, P = 0.03), and peak inspiratory flow (+35% ± 42%, P = 0.049) but did not change other spirometry measures, plasma cytokine concentrations, DNA damage levels in peripheral blood mononuclear cells, dynamic inspiratory muscle function, inspiratory muscle endurance, exercise performance,
PAL, or QoL.

Conclusion: These novel data indicate that in healthy older adults, IMT elicits some positive changes in inspiratory muscle function and structure but neither attenuates systemic inflammation and oxidative stress nor improves exercise performance, PAL, or QoL.

Keywordsinspiratory muscle structure; inspiratory muscle function; cytokines; oxidative stress
ANZSRC Field of Research 2020420702. Exercise physiology
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsNottingham Trent University, United Kingdom
Nottingham University Hospitals, United Kingdom
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q35q9/the-effects-of-inspiratory-muscle-training-in-older-adults

  • 1794
    total views
  • 10
    total downloads
  • 6
    views this month
  • 0
    downloads this month

Export as

Related outputs

Differences in total cognition and cerebrovascular function in female breast cancer survivors and cancer-free women
Downs, Tahnee L., Whiteside, Eliza J., Foot, Gaye, Mills, Dean E. and Bliss, Edward S.. 2023. "Differences in total cognition and cerebrovascular function in female breast cancer survivors and cancer-free women." The Breast. 69, pp. 358-365. https://doi.org/10.1016/j.breast.2023.03.018
Biomarkers to measure respiratory muscle damage following inspiratory pressure threshold loading in healthy young men
Iqbal, Muneeb, Bliss, Edward, Whiteside, Eliza, Hoffman, Ben and Mills, Dean E,. 2023. "Biomarkers to measure respiratory muscle damage following inspiratory pressure threshold loading in healthy young men." Journal of Applied Physiology. 134 (4), pp. 1038-1046. https://doi.org/10.1152/japplphysiol.00656.2022
Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing
Thornton, Tammy, Mills, Dean and Bliss, Edward. 2023. "Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing ." Nutrients. 15 (6). https://doi.org/10.3390/nu15061537
The impact of lipopolysaccharide on cerebrovascular function and cognition resulting from obesity-induced gut dysbiosis
Thornton, Tammy, Mills, Dean and Bliss, Edward. 2023. "The impact of lipopolysaccharide on cerebrovascular function and cognition resulting from obesity-induced gut dysbiosis." Life Sciences. 336. https://doi.org/10.1016/j.lfs.2023.122337
The benefits of regular aerobic exercise training on cerebrovascular function and cognition in older adults
Bliss, Edward S., Biki, Samia M., Wong, Rachel H. X., Howe, Peter R. C. and Mills, Dean E.. 2023. "The benefits of regular aerobic exercise training on cerebrovascular function and cognition in older adults." European Journal of Applied Physiology. 123 (6), pp. 1323-1342. https://doi.org/10.1007/s00421-023-05154-y
A student-run exercise physiology clinic in Australia: who and what do we see?
Hume, E., Cameron, M., Findley, I., Smart, S., Elisaia, C., Hulme, A., Mills, D. and Denham, J.. 2023. "A student-run exercise physiology clinic in Australia: who and what do we see? " 2023 ASICS SMA Conference (ASICS SMA 2023). Sunshine Coast, Australia 11 - 14 Oct 2023 Australia. Elsevier. https://doi.org/10.1016/j.jsams.2023.08.107
The effects of age on dyspnea and respiratory mechanical and neural responses to exercise in healthy men
MacAskill, William, Hoffman, Ben, Johnson, Michael A., Sharpe, Graham R., Rands, Joshua, Wotherspoon, Shoena E., Gevorkov, Yaroslav, Kolbe-Alexander, Tracy L. and Mills, Dean E.. 2023. "The effects of age on dyspnea and respiratory mechanical and neural responses to exercise in healthy men." Physiological Reports. 11 (16). https://doi.org/10.14814/phy2.15794
The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults
Bliss, Edward S., Wong, Rachel W. X., Howe, Peter R. C. and Mills, Dean E.. 2022. "The Effects of Aerobic Exercise Training on Cerebrovascular and Cognitive Function in Sedentary, Obese, Older Adults." Frontiers in Aging Neuroscience. 14, pp. 1-15. https://doi.org/10.3389/fnagi.2022.892343
The Effects Of Age On Exercise-induced Abdominal Muscle Fatigue In Healthy Younger And Older Men
Mills, Dean, Hoffman, Ben, Johnson, Michael A., Sharpe, Graham R., Rands, Joshua, Wotherspoon, Shoena E, Gevorkov, Yaroslav, Kolbe-Alexander, Tracy and MacAskill, William. 2022. "The Effects Of Age On Exercise-induced Abdominal Muscle Fatigue In Healthy Younger And Older Men." Medicine and Science in Sports and Exercise. 54 (9S), pp. 539-239. https://doi.org/10.1249/01.mss.0000881828.14030.71
Beyond criticism of ethics review boards: strategies for engaging research communities and enhancing ethical review processes
Hickey, Andrew, Davis, Samantha, Farmer, Will, Dawidowicz, Julianna, Moloney, Clint, Lamont-Mills, Andrea, Carniel, Jess, Pillay, Yosheen, Akenson, David, Bromdal, Annette, Gehrmann, Richard, Mills, Dean, Kolbe-Alexander, Tracy, Machin, Tanya, Reich, Suzanne, Southey, Kim, Crowley-Cyr, Lynda, Watanabe, Taiji, Davenport, Josh, ..., Maxwell, Jacinta. 2021. "Beyond criticism of ethics review boards: strategies for engaging research communities and enhancing ethical review processes." Journal of Academic Ethics. 20, pp. 549-567. https://doi.org/10.1007/s10805-021-09430-4
The control of respiratory pressures and neuromuscular activation to increase force production in trained martial arts practitioners
Walters, Sherrilyn, Hoffman, Ben, MacAskill, William, Johnson, Michael A., Sharpe, Graham R. and Mills, Dean E.. 2021. "The control of respiratory pressures and neuromuscular activation to increase force production in trained martial arts practitioners." European Journal of Applied Physiology. 121 (12), pp. 3333-3347. https://doi.org/10.1007/s00421-021-04800-7
Pressure measurement characteristics of a micro‐transducer and balloon catheters
MacAskill, William, Hoffman, Ben, Johnson, Michael A., Sharpe, Graham R. and Mills, Dean E.. 2021. "Pressure measurement characteristics of a micro‐transducer and balloon catheters." Physiological Reports. 9 (8). https://doi.org/10.14814/phy2.14831
Benefits of exercise training on cerebrovascular and cognitive function in ageing
Bliss, Edward S., Wong, Rachel H. X., Howe, Peter R. C. and Mills, Dean E.. 2021. "Benefits of exercise training on cerebrovascular and cognitive function in ageing." Journal of Cerebral Blood Flow and Metabolism. 41 (3), pp. 447-470. https://doi.org/10.1177/0271678X20957807
Comparing response, relaxation and measurement characteristics of balloon versus micro pressure transducer catheters
MacAskill, William, Hoffman, Ben, Sharpe, Graham, Johnson, Michael and Mills, Dean. 2019. "Comparing response, relaxation and measurement characteristics of balloon versus micro pressure transducer catheters." European Respiratory Society International Congress 2019. Madrid, Spain 28 Sep - 02 Oct 2019 Sheffield, United Kingdom. https://doi.org/10.1183/13993003.congress-2019.PA752
In vivo characteristics of respiratory neuromuscular responses with balloon catheters and skin surface EMG versus a micro transducer catheter integrated with EMG electrodes
MacAskill, William, Hoffman, Ben, Sharpe, Graham, Johnson, Michael and Mills, Dean. 2019. "In vivo characteristics of respiratory neuromuscular responses with balloon catheters and skin surface EMG versus a micro transducer catheter integrated with EMG electrodes." European Respiratory Society International Congress 2019. Madrid, Spain 28 Sep - 02 Oct 2019 Sheffield, United Kingdom. https://doi.org/10.1183/13993003.congress-2019.PA761
Inspiratory flow-resistive breathing, respiratory muscle-induced systemic oxidative stress, and diaphragm fatigue in healthy humans
Briskey, David R., Vogel, Kurt, Johnson, Michael A., Sharpe, Graham R., Coombes, Jeff S. and Mills, Dean E.. 2020. "Inspiratory flow-resistive breathing, respiratory muscle-induced systemic oxidative stress, and diaphragm fatigue in healthy humans." Journal of Applied Physiology. 129 (1), pp. 185-193. https://doi.org/10.1152/japplphysiol.00091.2020
The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study
Mallard, Alistair, Briskey, David, Richards, Andrew, Mills, Dean and Rao, Amanda. 2020. "The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study." Nutrients. 12 (3), pp. 1-13. https://doi.org/10.3390/nu12030596
Oxygen supplementation for preventing adverse outcomes following surgery or invasive procedures
Eager, Amanda, Ralph, Nicholas, Duff, Jed, Conway, Aaron and Mills, Dean. 2017. "Oxygen supplementation for preventing adverse outcomes following surgery or invasive procedures." PROSPERO: International Prospective Register of Systematic Reviews. 16 June 2017.
Inspiratory muscle warm-up does not improve cycling time trial performance
Gregson, Ian, Mills, Dean, Gonzalez, Javier, Sharpe, Graham and Johnson, Michael. 2012. "Inspiratory muscle warm-up does not improve cycling time trial performance." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
The effects of pressure-threshold inspiratory load on lactate clearance after maximal exercise
Johnson, Michael, Brown, David, Bayfield, Katie, Gonzalez, Javier, Mills, Dean and Sharpe, Graham. 2011. "The effects of pressure-threshold inspiratory load on lactate clearance after maximal exercise." 21st European Respiratory Society Annual Congress. Amsterdam, Netherlands 24 - 28 Sep 2011 Switzerland.
The effects of inspiratory muscle training on breathing mechanics during fixed load cycling exercise
Mills, Dean, Sharpe, Graham, Johnson, Michael and Barnett, Yvonne. 2011. "The effects of inspiratory muscle training on breathing mechanics during fixed load cycling exercise." 21st European Respiratory Society Annual Congress. Amsterdam, Netherlands 24 - 28 Sep 2011 Switzerland.
The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea
Mills, Dean, Johnson, Michael, McPhilimey, Martin, Williams, Neil, Gonzalez, Javier, Barnett, Yvonne and Sharpe, Graham. 2012. "The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea
Mills, Dean, Johnson, Michael, McPhilimey, Martin, Williams, Neil, Gonzalez, Javier, Barnett, Yvonne and Sharpe, Graham. 2012. "The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea." 22nd European Respiratory Society Annual Congress. Vienna, Austria 01 - 05 Sep 2012 Switzerland.
Inspiratory loading intensity does not influence lactate clearance during recovery
Johnson, Michael A., Mills, Dean E., Brown, David M., Bayfield, Katie J., Gonzalez, Javier T. and Sharpe, Graham R.. 2012. "Inspiratory loading intensity does not influence lactate clearance during recovery." Medicine and Science in Sports and Exercise. 44 (5), pp. 863-871. https://doi.org/10.1249/MSS.0b013e31824079d0
Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation
Mills, Dean E., Johnson, Michael A., McPhilimey, Martin J., Williams, Neil C., Gonzalez, Javier T., Barnett, Yvonne A. and Sharpe, Graham R.. 2014. "Influence of oxidative stress, diaphragm fatigue and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation." Journal of Applied Physiology. 116 (8), pp. 970-979. https://doi.org/10.1152/japplphysiol.01271.2013
Prior upper body exercise reduces cycling work capacity but not critical power
Johnson, Michael A., Mills, Dean E., Brown, Peter I. and Sharpe, Graham R.. 2014. "Prior upper body exercise reduces cycling work capacity but not critical power." Medicine and Science in Sports and Exercise. 46 (4), pp. 802-808. https://doi.org/10.1249/MSS.0000000000000159
The effects of inspiratory muscle training on plasma interleukin-6 concentration during cycling exercise and a volitional mimic of the exercise hyperpnea
Mills, Dean E., Johnson, Michael A., McPhilimey, Martin J., Williams, Neil C., Gonzalez, Javier T., Barnett, Yvonne A. and Sharpe, Graham R.. 2013. "The effects of inspiratory muscle training on plasma interleukin-6 concentration during cycling exercise and a volitional mimic of the exercise hyperpnea." Journal of Applied Physiology. 115 (8), pp. 1163-1172. https://doi.org/10.1152/japplphysiol.00272.2013
Response [to the Chiappa et al letter to the editor]
Johnson, Michael A., Mills, Dean E., Brown, Peter I. and Sharpe, Graham R.. 2013. "Response [to the Chiappa et al letter to the editor]." Medicine and Science in Sports and Exercise. 45 (1), pp. 214-215. https://doi.org/10.1249/MSS.0b013e31826aade2
Inspiratory muscle warm-up does not improve cycling time-trial performance
Johnson, M. A., Gregson, I. R., Mills, D. E., Gonzalez, J. T. and Sharpe, G. R.. 2014. "Inspiratory muscle warm-up does not improve cycling time-trial performance." European Journal of Applied Physiology. 114 (9), pp. 1821-1830. https://doi.org/10.1007/s00421-014-2914-x