Triacylglycerol-lowering effect of docosahexaenoic acid is not influenced by single-nucleotide polymorphisms involved in lipid metabolism in humans

Article

AbuMweis, Suhad S., Panchal, Sunil K. and Jones, Peter J. H.. 2018. "Triacylglycerol-lowering effect of docosahexaenoic acid is not influenced by single-nucleotide polymorphisms involved in lipid metabolism in humans." Lipids. 53 (9), pp. 897-908. https://doi.org/10.1002/lipd.12096
Article Title

Triacylglycerol-lowering effect of docosahexaenoic acid is not influenced by single-nucleotide polymorphisms involved in lipid metabolism in humans

ERA Journal ID15273
Article CategoryArticle
AuthorsAbuMweis, Suhad S. (Author), Panchal, Sunil K. (Author) and Jones, Peter J. H. (Author)
Journal TitleLipids
Journal Citation53 (9), pp. 897-908
Number of Pages12
Year2018
Place of PublicationGermany
ISSN0024-4201
1558-9307
Digital Object Identifier (DOI)https://doi.org/10.1002/lipd.12096
Web Address (URL)https://www.ncbi.nlm.nih.gov/pubmed/30407633
Abstract

The triacylglycerol (TAG)-lowering effects of long-chain n-3 fatty acids, and in particular docosahexaenoic acid (DHA), are well documented, although these effects manifest large interindividual variability. The objective of this secondary analysis is to investigate whether common single-nucleotide polymorphisms (SNP) in genes involved in DHA synthesis and TAG metabolism are associated with the responsiveness of blood lipids, lipoprotein, and apolipoprotein concentration to dietary treatment by DHA supplied in high-oleic canola oil (HOCO). In a randomized, crossover-controlled feeding trial, 129 subjects with metabolic syndrome received high-oleic canola oil (HOCO) and high-oleic canola oil supplemented with DHA (HOCO-DHA), each for 4 weeks. During the HOCO-DHA phase, the intake of DHA ranged from 1 to 2.5 g/day. The subjects were genotyped for apolipoprotein E (APOE) isoforms, and SNP including FADS1-rs174561, FADS2-rs174583, ELOVL2-rs953413, ELOVL5-rs2397142, CETP-rs5882, SCD1-rs2234970, PPARA-rs6008259, and LIPF-rs814628 were selected as important genes controlling fatty acid metabolism. Overall, consumption of HOCO-DHA oil reduced blood concentrations of TAG by 24% compared to HOCO oil. The reduction in TAG was independent of genetic variations in the studied genes. Similarly, no treatment-by-gene interactions were evident in the response to other lipids, lipoproteins, or apolipoproteins to DHA supplementation. Nevertheless, a lower interindividual variation in the TAG response to DHA supplementation compared to other studies was observed in this analysis. The TAG-lowering effect of a supplemental body-weight-based dose of DHA was not influenced by genetic variations in APOE, FADS1, FADS2, ELOVL2, ELOVL5, CETP, SCD1, PPARA, and LIPF.

Keywordsadults; docosahexenoic acid; genetics; lLipoprotein; single-nucleotide polymorphism
ANZSRC Field of Research 2020321004. Nutritional science
321401. Basic pharmacology
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Byline AffiliationsHashemite University, Jordan
Institute for Agriculture and the Environment
University of Manitoba, Canada
Institution of OriginUniversity of Southern Queensland
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