Kappaphycus alvarezii as a food supplement prevents diet-induced metabolic syndrome in rats
Article
Article Title | Kappaphycus alvarezii as a food supplement prevents diet-induced metabolic syndrome in rats |
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ERA Journal ID | 211152 |
Article Category | Article |
Authors | Wanyonyi, Stephen (Author), du Preez, Ryan (Author), Brown, Lindsay (Author), Paul, Nicholas A. (Author) and Panchal, Sunil K. (Author) |
Journal Title | Nutrients |
Journal Citation | 9 (11) |
Number of Pages | 16 |
Year | 2017 |
Publisher | MDPI AG |
Place of Publication | Switzerland |
ISSN | 2072-6643 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/nu9111261 |
Web Address (URL) | http://www.mdpi.com/2072-6643/9/11/1261 |
Abstract | The red seaweed, Kappaphycus alvarezii, was evaluated for its potential to prevent signs of metabolic syndrome through use as a whole food supplement. Major biochemical components of dried Kappaphycus are carrageenan (soluble fiber ~34.6%) and salt (predominantly potassium (K) 20%) with a low overall energy content for whole seaweed. Eight to nine week old male Wistar rats were randomly divided into three groups and fed for 8 weeks on a corn starch diet, a high-carbohydrate, high-fat (H) diet, alone or supplemented with a 5% (w/w) dried and milled Kappaphycus blended into the base diet. H-fed rats showed symptoms of metabolic syndrome including increased body weight, total fat mass, systolic blood pressure, left ventricular collagen deposition, plasma triglycerides, and plasma non-esterified fatty acids along with fatty liver. Relative to these obese rats, Kappaphycus-treated rats showed normalized body weight and adiposity, lower systolic blood pressure, improved heart and liver structure, and lower plasma lipids, even in presence of H diet. Kappaphycus modulated the balance between Firmicutes and Bacteroidetes in the gut, which could serve as the potential mechanism for improved metabolic variables; this was accompanied by no damage to the gut structure. Thus, whole Kappaphycus improved cardiovascular, liver, and metabolic parameters in obese rats. |
Keywords | metabolic syndrome; red seaweed; obesity; inflammation; carrageenan; Kappaphycus alvarezii |
ANZSRC Field of Research 2020 | 321099. Nutrition and dietetics not elsewhere classified |
Byline Affiliations | Institute for Agriculture and the Environment |
School of Health and Wellbeing | |
University of the Sunshine Coast | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q4848/kappaphycus-alvarezii-as-a-food-supplement-prevents-diet-induced-metabolic-syndrome-in-rats
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