Endurance exercise in a rat model of metabolic syndrome
Article
Article Title | Endurance exercise in a rat model of metabolic syndrome |
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ERA Journal ID | 14592 |
Article Category | Article |
Authors | Cameron, Isabelle (Author), Alam, Mohammed Ashraful (Author), Wang, Jianxiong (Author) and Brown, Lindsay (Author) |
Journal Title | Canadian Journal of Physiology and Pharmacology |
Journal Citation | 90 (11), pp. 1490-1497 |
Number of Pages | 8 |
Year | 2012 |
Place of Publication | Canada |
ISSN | 0008-4212 |
1205-7541 | |
Digital Object Identifier (DOI) | https://doi.org/10.1139/y2012-097 |
Web Address (URL) | http://www.nrcresearchpress.com/doi/abs/10.1139/y2012-097#.UUBnrzf7D0c |
Abstract | We have measured the responses to endurance exercise training on body composition and glucose regulation, as well as cardiovascular and liver structure and function in rats fed a high carbohydrate and high fat (HCHF) diet as a model of human metabolic syndrome. Male Wistar rats (9-10 weeks old) were randomly allocated into corn starch (CS) or HCHF diet groups for 16 weeks; half of each group were exercised on a treadmill for 20, 25, and then 30 min/day, 5 days/week, during the last 8 weeks of the protocol. Metabolic, cardiovascular, and liver parameters were monitored. The HCHF diet induced symptoms of metabolic syndrome, including obesity, dyslipidemia, impaired glucose tolerance, and increased systolic blood pressure associated with the development of cardiovascular remodeling and nonalcoholic steatohepatitis. Exercise in HCHF rats decreased body mass, abdominal fat pads and circumference, blood glucose concentrations, plasma lipid profiles, systolic blood pressure, left ventricular diastolic stiffness, collagen deposition and inflammatory cell infiltration in the left ventricle, improved aortic contractile and relaxation responses, and decreased liver mass and hepatic fat accumulation. This study demonstrates that endurance exercise is effective in this rat model of diet-induced metabolic syndrome in improving body composition and glucose regulation, as well as cardiovascular and liver structure and function. |
Keywords | body composition, glucose tolerance, cardiac remodeling, endothelial dysfunction, liver function |
ANZSRC Field of Research 2020 | 320899. Medical physiology not elsewhere classified |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Department of Biological and Physical Sciences |
University of Queensland | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q19x6/endurance-exercise-in-a-rat-model-of-metabolic-syndrome
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