High-intensity interval training and moderate-intensity continuous training attenuate oxidative damage and promote myokine response in the skeletal muscle of ApoE KO mice on high-fat diet

Article


Wang, Linjia, Lavier, Jessica, Hua, Weicheng, Wang, Yangwenjie, Gong, Lijing, Wei, Hao, Wang, Jianxiong, Pellegrin, Maxime, Millet, Gregoire P. and Zhang, Ying. 2021. "High-intensity interval training and moderate-intensity continuous training attenuate oxidative damage and promote myokine response in the skeletal muscle of ApoE KO mice on high-fat diet." Antioxidants. 10 (7). https://doi.org/10.3390/antiox10070992
Article Title

High-intensity interval training and moderate-intensity
continuous training attenuate oxidative damage and promote myokine response in the skeletal muscle of ApoE KO mice on high-fat diet

ERA Journal ID211760
Article CategoryArticle
AuthorsWang, Linjia (Author), Lavier, Jessica (Author), Hua, Weicheng (Author), Wang, Yangwenjie (Author), Gong, Lijing (Author), Wei, Hao (Author), Wang, Jianxiong (Author), Pellegrin, Maxime (Author), Millet, Gregoire P. (Author) and Zhang, Ying (Author)
Journal TitleAntioxidants
Journal Citation10 (7)
Article Number992
Number of Pages14
Year2021
PublisherMDPI AG
Place of PublicationBasel, Switzerland
ISSN2076-3921
Digital Object Identifier (DOI)https://doi.org/10.3390/antiox10070992
Web Address (URL)https://www.mdpi.com/2076-3921/10/7/992
Abstract

The purpose of this study was to investigate the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the skeletal muscle in Apolipoprotein E knockout (ApoE KO) and wild-type (WT) C57BL/6J mice. ApoE KO mice fed with a high-fat
diet were randomly allocated into: Control group without exercise (ApoE−/− CON), HIIT group (ApoE−/− HIIT), and MICT group (ApoE−/− MICT). Exercise endurance, blood lipid profile, muscle antioxidative capacity, and myokine production were measured after six weeks of interventions. ApoE−/− CON mice exhibited hyperlipidemia and increased oxidative stress, compared to the WT mice. HIIT and MICT reduced blood lipid levels, ROS production, and protein carbonyl content in the skeletal muscle, while it enhanced the GSH generation and potently promoted mRNA expression of genes involved in the production of irisin and BAIBA. Moreover, ApoE−/− HIIT mice had significantly lower plasma HDL-C content, mRNA expression of MyHC-IIx and Vegfa165 in EDL, and ROS level; but remarkably higher mRNA expression of Hadha in the skeletal muscle than those of ApoE−/− MICT mice. These results demonstrated that both exercise programs were effective for the ApoE KO mice by attenuating the oxidative damage and promoting the myokines response and
production. In particular, HIIT was more beneficial to reduce the ROS level in the skeletal muscle.

KeywordsHIIT; atherosclerosis; ApoE KO mice; skeletal muscle; oxidative damage; myokine production
ANZSRC Field of Research 2020310103. Cell metabolism
420702. Exercise physiology
Public Notes

Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://
creativecommons.org/licenses/by/4.0/).

Byline AffiliationsBeijing Sport University, China
University of Lausanne, Switzerland
School of Health and Wellbeing
Lausanne University Hospital, Switzerland
Institution of OriginUniversity of Southern Queensland
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