Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin-knockout mice

Article

He, Shiyi, Li, Junping, Wang, Jianxiong and Zhang, Ying. 2019. "Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin-knockout mice." FEBS Open Bio. 9 (3), pp. 498-509. https://doi.org/10.1002/2211-5463.12587
Article Title

Hypoxia exposure alleviates impaired muscular
metabolism, glucose tolerance, and aerobic capacity in
apelin-knockout mice

ERA Journal ID212493
Article CategoryArticle
AuthorsHe, Shiyi (Author), Li, Junping (Author), Wang, Jianxiong (Author) and Zhang, Ying (Author)
Journal TitleFEBS Open Bio
Journal Citation9 (3), pp. 498-509
Number of Pages12
Year2019
PublisherJohn Wiley & Sons
Place of PublicationUnited Kingdom
ISSN2211-5463
Digital Object Identifier (DOI)https://doi.org/10.1002/2211-5463.12587
Web Address (URL)https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.12587
Abstract

High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein-coupled receptor APJ and has possible roles in energy metabolism. Apelin-null mice have been reported to exhibit impaired insulin sensitivity, which can be reversed by supplementation of exogenous apelin. Here, we examined the effects of 4 weeks’ intermittent hypoxia exposure on physiological and biochemical variables in apelin knockout (KO) mice. Apelin KO mice exhibited decreased expression of substrate metabolism-associated genes/proteins, impaired glucose tolerance, and reduced exercise capacity compared to wild-type mice, and all of these effects were rescued by hypoxia. These findings suggest that hypoxia intervention may possibly be able to alleviate metabolic conditions caused by genetic defects.

Keywordsapelin; diabetes; hypoxia; metabolic disorder
ANZSRC Field of Research 2020320801. Cell physiology
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Byline AffiliationsBeijing Sport University, China
Faculty of Health, Engineering and Sciences
Institution of OriginUniversity of Southern Queensland
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