Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin-knockout mice
Article
Article Title | Hypoxia exposure alleviates impaired muscular |
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ERA Journal ID | 212493 |
Article Category | Article |
Authors | He, Shiyi (Author), Li, Junping (Author), Wang, Jianxiong (Author) and Zhang, Ying (Author) |
Journal Title | FEBS Open Bio |
Journal Citation | 9 (3), pp. 498-509 |
Number of Pages | 12 |
Year | 2019 |
Publisher | John Wiley & Sons |
Place of Publication | United Kingdom |
ISSN | 2211-5463 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/2211-5463.12587 |
Web Address (URL) | https://febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.12587 |
Abstract | High altitude hypoxia adaptation can improve glucose tolerance in people with metabolic syndrome and type 2 diabetes (T2D). Apelin is an endogenous ligand of the G protein-coupled receptor APJ and has possible roles in energy metabolism. Apelin-null mice have been reported to exhibit impaired insulin sensitivity, which can be reversed by supplementation of exogenous apelin. Here, we examined the effects of 4 weeks’ intermittent hypoxia exposure on physiological and biochemical variables in apelin knockout (KO) mice. Apelin KO mice exhibited decreased expression of substrate metabolism-associated genes/proteins, impaired glucose tolerance, and reduced exercise capacity compared to wild-type mice, and all of these effects were rescued by hypoxia. These findings suggest that hypoxia intervention may possibly be able to alleviate metabolic conditions caused by genetic defects. |
Keywords | apelin; diabetes; hypoxia; metabolic disorder |
ANZSRC Field of Research 2020 | 320801. Cell physiology |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Beijing Sport University, China |
Faculty of Health, Engineering and Sciences | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q50zx/hypoxia-exposure-alleviates-impaired-muscular-metabolism-glucose-tolerance-and-aerobic-capacity-in-apelin-knockout-mice
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