Hypoxic exercise training promotes apelin/APJ expression in skeletal muscles of high fat diet-induced obese mice

Article

Ji, Weixiu, Gong, Lijing, Wang, Jianxiong, He, Hui and Zhang, Ying. 2017. "Hypoxic exercise training promotes apelin/APJ expression in skeletal muscles of high fat diet-induced obese mice." Protein and Peptide Letters: international journal for rapid publication of short papers in protein and peptide science. 24 (1), pp. 64-70. https://doi.org/10.2174/0929866524666161111111726
Article Title

Hypoxic exercise training promotes apelin/APJ expression in skeletal muscles of high fat diet-induced obese mice

ERA Journal ID2351
Article CategoryArticle
AuthorsJi, Weixiu (Author), Gong, Lijing (Author), Wang, Jianxiong (Author), He, Hui (Author) and Zhang, Ying (Author)
Journal TitleProtein and Peptide Letters: international journal for rapid publication of short papers in protein and peptide science
Journal Citation24 (1), pp. 64-70
Number of Pages7
Year2017
Place of PublicationNetherlands
ISSN0929-8665
1875-5305
Digital Object Identifier (DOI)https://doi.org/10.2174/0929866524666161111111726
Web Address (URL)http://www.eurekaselect.com/147319/article
Abstract

Apelin, an endogenous ligand of the G-protein-coupled receptor APJ, is a novel myokine and may play a key role in regulating energy metabolism. The purpose of the present study was to investigate the effects of hypoxic exposure, exercise, and hypoxic exercise training on the expression of apelin and APJ in skeletal muscle of obese mice. 60 two-month old C57BL/6J mice were randomly divided into two groups: 10 in normal diet group (N) and 50 in the high fat diet (HFD) groups. After two months of feeding, the HFD mice whose body weight 20% higher than the average weight of N group were selected as obese mice and were further allocated into four groups: Control (C), Exercise (E), Hypoxia (H), and Exercise plus Hypoxia (E+H), at 8-9 mice/group. Besides body weight, measured variables in skeletal muscle were protein/mRNA levels of apelin/APJ, AMPKα-Thr172 phosphorylation, hypoxia inducible factor-1α (HIF-1α), mRNA levels of peroxisome proliferator-activated receptorα (PPARα), estrogen-related receptor (ERRα), and nuclear respiratory factor1 (NRF1). Obese mice had significantly lower mRNA and protein expressions of apelin/APJ in skeletal muscles than the normal body weight mice. After four weeks of interventions, hypoxic exercise training decreased body weight and increased mRNA and protein expressions of apelin and APJ, mRNA expression of ERRα, and protein expression of HIF-1α. These results indicate that changes of body weight may be associated with the levels of apelin/APJ expressions in skeletal muscle.

Keywordshypoxic exercise training; apelin; APJ; skeletal muscle; obese mice
ANZSRC Field of Research 2020310199. Biochemistry and cell biology not elsewhere classified
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Byline AffiliationsBeijing Sport University, China
Faculty of Health, Engineering and Sciences
Institution of OriginUniversity of Southern Queensland
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