Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats
Article
Article Title | Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats |
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ERA Journal ID | 14994 |
Article Category | Article |
Authors | Kumar, Senthil Arun (Author), Magnusson, Marie (Author), Ward, Leigh C. (Author), Paul, Nicholas A. (Author) and Brown, Lindsay (Author) |
Journal Title | Marine Drugs |
Journal Citation | 13 (2), pp. 788-805 |
Number of Pages | 18 |
Year | 2015 |
Place of Publication | Basel, Switzerland |
ISSN | 1660-3397 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/md13020788 |
Web Address (URL) | http://www.mdpi.com/1660-3397/13/2/788 |
Abstract | Increased seaweed consumption may be linked to the lower incidence of metabolic syndrome in eastern Asia. This study investigated the responses to two tropical green seaweeds, Ulva ohnoi (UO) and Derbesia tenuissima (DT), in a rat model of human metabolic syndrome. Male Wistar rats (330-340 g) were fed either a corn starch-rich diet or a high-carbohydrate, high-fat diet with 25% fructose in drinking water, for 16 weeks. High-carbohydrate, high-fat diet-fed rats showed the signs of metabolic syndrome leading to abdominal obesity, cardiovascular remodelling and non-alcoholic fatty liver disease. Food was supplemented with 5% dried UO or DT for the final 8 weeks only. UO lowered total final body fat mass by 24%, systolic blood pressure by 29 mmHg, and improved glucose utilisation and insulin sensitivity. In contrast, DT did not change total body fat mass but decreased plasma triglycerides by 38% and total cholesterol by 17%. UO contained 18.1% soluble fibre as part of 40.9% total fibre, and increased magnesium, while DT contained 23.4% total fibre, essentially as insoluble fibre. UO was more effective in reducing metabolic syndrome than DT, possibly due to the increased intake of soluble fibre and magnesium. |
Keywords | obesity; hypertension; fatty liver; tropical seaweeds; soluble fibre |
ANZSRC Field of Research 2020 | 320502. Medical biochemistry - carbohydrates |
321401. Basic pharmacology | |
340502. Natural products and bioactive compounds | |
Public Notes | © 2015 by the authors. Open Access Journal. This publication is copyright. It may be reproduced in whole or in part for the purposes of study, research, or review, but is subject to the inclusion of an acknowledgment of the source. |
Byline Affiliations | School of Health and Wellbeing |
James Cook University | |
University of Queensland | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q2xw3/seaweed-supplements-normalise-metabolic-cardiovascular-and-liver-responses-in-high-carbohydrate-high-fat-fed-rats
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