Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats
Article
Article Title | Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats |
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ERA Journal ID | 13658 |
Article Category | Article |
Authors | Panchal, Sunil K. (Author), Poudyal, Hemant (Author), Waanders, Jennifer (Author) and Brown, Lindsay (Author) |
Journal Title | The Journal of Nutrition |
Journal Citation | 142 (4), pp. 690-697 |
Number of Pages | 8 |
Year | 2012 |
Place of Publication | Bethesda, MD. United States |
ISSN | 0022-3166 |
1541-6100 | |
Digital Object Identifier (DOI) | https://doi.org/10.3945/jn.111.153577 |
Web Address (URL) | http://jn.nutrition.org/content/142/4/690 |
Abstract | Coffee, a rich source of natural products, including caffeine, chlorogenic acid, and diterpenoid alcohols, has been part of the human diet since the 15th century. In this study, we characterized the effects of Colombian coffee extract (CE), which contains high concentrations of caffeine and diterpenoids, on a rat model of human metabolic syndrome. The 8–9 wk old male Wistar rats were divided into four groups. Two groups of rats were fed a corn starch-rich diet whereas the other two groups were given a high-carbohydrate, high-fat diet with 25% fructose in drinking water for 16 wk. One group fed each diet was supplemented with 5% aqueous CE for the final 8 wk of this protocol. The corn starch diet contained ~68% carbohydrates mainly as polysaccharides, whereas the high-carbohydrate, high-fat diet contained ~68% carbohydrates mainly as fructose and sucrose together with 24% fat, mainly as saturated and monounsaturated fat from beef tallow. The high-carbohydrate, high-fat diet-fed rats showed the symptoms of metabolic syndrome leading to cardiovascular remodeling and nonalcoholic fatty liver disease. CE supplementation attenuated impairment in glucose tolerance, hypertension, cardiovascular remodeling, and nonalcoholic fatty liver disease without changing abdominal obesity and dyslipidemia. This study suggests that CE can attenuate diet-induced changes in the structure and function of the heart and the liver without changing the abdominal fat deposition. |
Keywords | abdominal obesity; albumin blood level; animal tissue; bilirubin blood level; blood vessel reactivity; carbohydrate diet; cholesterol blood level; coffee; concentration (parameters); dyslipidemia; fatty liver; glucose blood level; glucose tolerance; heart ventricle remodeling; heart weight |
ANZSRC Field of Research 2020 | 320507. Metabolic medicine |
310912. Comparative physiology | |
321004. Nutritional science | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Department of Biological and Physical Sciences |
University of Queensland | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q179x/coffee-extract-attenuates-changes-in-cardiovascular-and-hepatic-structure-and-function-without-decreasing-obesity-in-high-carbohydrate-high-fat-diet-fed-male-rats
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