The tammar wallaby: a marsupial model to examine the timed delivery and role of bioactives in milk

Article


Sharp, Julie A., Wanyonyi, Stephen, Modepalli, Vengama, Watt, Ashalyn, Kuruppath, Sanjana, Hinds, Lyn A., Kumar, Amit, Abud, Helen E., Lefevre, Christophe and Nicholas, Kevin R.. 2017. "The tammar wallaby: a marsupial model to examine the timed delivery and role of bioactives in milk." General and Comparative Endocrinology. 244, pp. 164-177. https://doi.org/10.1016/j.ygcen.2016.08.007
Article Title

The tammar wallaby: a marsupial model to examine the timed delivery and role of bioactives in milk

ERA Journal ID16149
Article CategoryArticle
AuthorsSharp, Julie A. (Author), Wanyonyi, Stephen (Author), Modepalli, Vengama (Author), Watt, Ashalyn (Author), Kuruppath, Sanjana (Author), Hinds, Lyn A. (Author), Kumar, Amit (Author), Abud, Helen E. (Author), Lefevre, Christophe (Author) and Nicholas, Kevin R. (Author)
Journal TitleGeneral and Comparative Endocrinology
Journal Citation244, pp. 164-177
Number of Pages14
Year2017
Place of PublicationUnited States
ISSN0016-6480
1095-6840
Digital Object Identifier (DOI)https://doi.org/10.1016/j.ygcen.2016.08.007
Web Address (URL)https://www.sciencedirect.com/science/article/pii/S0016648016302374
Abstract

It is now clear that milk has multiple functions; it provides the most appropriate nutrition for growth of the newborn, it delivers a range of bioactives with the potential to stimulate development of the young, it has the capacity to remodel the mammary gland (stimulate growth or signal cell death) and finally milk can provide protection from infection and inflammation when the mammary gland is susceptible to these challenges. There is increasing evidence to support studies using an Australian marsupial, the tammar wallaby (Macropus eugenii), as an interesting and unique model to study milk bioactives. Reproduction in the tammar wallaby is characterized by a short gestation, birth of immature young and a long lactation. All the major milk constituents change substantially and progressively during lactation and these changes have been shown to regulate growth and development of the tammar pouch young and to have roles in mammary gland biology. This review will focus on recent reports examining the control of lactation in the tammar wallaby and the timed delivery of milk bioactivity.

Keywordslactation, milk, mammary gland, marsupial, monotreme
ANZSRC Field of Research 2020321401. Basic pharmacology
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Byline AffiliationsDeakin University
Deputy Vice-Chancellor's Office (Research and Innovation)
Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia
Monash University
Institution of OriginUniversity of Southern Queensland
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