Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator activated receptor y; (PPARy;)mRNA expression in visceral fat in the lamb

Article

Duffield, Jaime A., Vuocolo, Tony, Tellam, Ross, McFarlane, Jim R., Kauter, Kate G., Muhlhausler, B. S. and McMillen, I. Caroline. 2009. "Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator activated receptor y; (PPARy;)mRNA expression in visceral fat in the lamb." Pediatric Research. 66 (1), pp. 59-65. https://doi.org/10.1203/PDR.0b013e3181a7c121
Article Title

Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator activated receptor y; (PPARy;)mRNA expression in visceral fat in the lamb

ERA Journal ID16751
Article CategoryArticle
AuthorsDuffield, Jaime A. (Author), Vuocolo, Tony (Author), Tellam, Ross (Author), McFarlane, Jim R. (Author), Kauter, Kate G. (Author), Muhlhausler, B. S. (Author) and McMillen, I. Caroline (Author)
Journal TitlePediatric Research
Journal Citation66 (1), pp. 59-65
Number of Pages7
Year2009
Place of PublicationPhiladelphia, PA. United States
ISSN0031-3998
1530-0447
Digital Object Identifier (DOI)https://doi.org/10.1203/PDR.0b013e3181a7c121
Abstract

Being born small is associated with an increased risk of visceral obesity and insulin resistance in adult life. We have investigated the effect of IUGR on adipogenic and lipogenic gene expression in visceral fat in the lamb at 3 wk of age. Perirenal fat mass, but not adipocyte size was greater in females than males, independent of birth weight. Plasma insulin concentrations during the first 24 h after birth predicted the size of the adipocytes and expression of adiponectin in visceral adipose tissue in both males and females. In females, plasma nonesterified fatty acids (NEFA) concentrations during the first 24 h after birth were directly related to peroxisome proliferator-activated receptor γ (PPARγ) mRNA expression in the perirenal fat depot at 3 wk of age. In the males, in contrast to the females, PPARγ and leptin expression in perirenal visceral fat were significantly lower in IUGR compared with control lambs. Thus, the early nutritional environment programs adipocyte growth and gene expression in visceral adipose tissue. The differential effect of sex and IUGR on PPARγ and leptin expression in visceral fat may be important in the subsequent development of visceral obesity and the insulin resistant phenotype in later life.

Keywordsgene expression regulation; metabolism; newborn; physiology; sheep; insulin; intra-abdominal fat; leptin
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Byline AffiliationsUniversity of Adelaide
Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia
University of New England
University of South Australia
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