Inflammation and Oral Contraceptive Use in Female Athletes Before the Rio Olympic Games

Article


Larsen, Brianna, Cox, Amanda, Colbey, Candice, Drew, Michael, McGuire, Helen, Fazekas de St Groth, Barbara, Hughes, David, Vlahovich, Nicole, Waddington, Gordon, Burke, Louise, Lundy, Bronwen, West, Nicholas and Minahan, Clare. 2020. "Inflammation and Oral Contraceptive Use in Female Athletes Before the Rio Olympic Games." Frontiers in Physiology. 11, pp. 1-8. https://doi.org/10.3389/fphys.2020.00497
Article Title

Inflammation and Oral Contraceptive Use in Female Athletes Before the Rio Olympic Games

ERA Journal ID200523
Article CategoryArticle
AuthorsLarsen, Brianna (Author), Cox, Amanda (Author), Colbey, Candice (Author), Drew, Michael (Author), McGuire, Helen (Author), Fazekas de St Groth, Barbara (Author), Hughes, David (Author), Vlahovich, Nicole (Author), Waddington, Gordon (Author), Burke, Louise (Author), Lundy, Bronwen (Author), West, Nicholas (Author) and Minahan, Clare (Author)
Journal TitleFrontiers in Physiology
Journal Citation11, pp. 1-8
Article Number497
Number of Pages8
Year2020
Place of PublicationSwitzerland
ISSN1664-042X
Digital Object Identifier (DOI)https://doi.org/10.3389/fphys.2020.00497
Web Address (URL)https://www.frontiersin.org/articles/10.3389/fphys.2020.00497/full
Abstract

This study investigated the association between synthetic ovarian hormone use [i.e., the oral contraceptive (OC) pill] and basal C-reactive protein (CRP), peripheral blood immune cell subsets, and circulating pro- and anti-inflammatory cytokine concentrations in elite female athletes. Elite female athletes (n = 53) selected in Rio Summer Olympic squads participated in this study; 25 were taking an OC (AthletesOC) and 28 were naturally hormonally cycling (AthletesNC). Venous blood samples were collected at rest for the determination of sex hormones, cortisol, CRP, peripheral blood mononuclear memory and naïve CD4+ T-cells, CD8+ T-cells and natural killer cells, as well as pro- and anti-inflammatory cytokine concentrations. C-reactive protein concentrations were elevated (p < 0.001) in AthletesOC (median = 2.02, IQR = 3.15) compared to AthletesNC (median = 0.57, IQR = 1.07). No differences were reported for cortisol, cytokines, or PBMC immune cell subsets, although there was a trend (p = 0.062) for higher IL-6 concentrations in AthletesNC. Female Olympians had substantially higher CRP concentrations, a marker of inflammation and tissue damage, before the Rio Olympic Games if they used an OC. Future research should examine the potential consequences for athlete performance/recovery so that, if necessary, practitioners can implement prevention programs.

KeywordsC-reactive protein, cytokines, contraception, athletes, sex hormones
ANZSRC Field of Research 2020320499. Immunology not elsewhere classified
320225. Sports medicine
Open access urlhttps://www.frontiersin.org/articles/10.3389/fphys.2020.00497/full
Institution of OriginUniversity of Southern Queensland
Byline AffiliationsGriffith University
Australian Institute of Sport, Australia
University of Sydney
University of Canberra
Permalink -

https://research.usq.edu.au/item/q5y1q/inflammation-and-oral-contraceptive-use-in-female-athletes-before-the-rio-olympic-games

Download files


Published Version
Larsen et al 2020_Rio paper.pdf
License: CC BY 4.0
File access level: Anyone

  • 121
    total views
  • 61
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Knowledge, Attitudes, and Behaviors Toward the Menstrual Cycle and Menstruation Among Elite African Women Football Players, Coaches, Health Personnel, and Referees
Mkumbuzi, Nonhlanhla S., Dlamini, Senanile B., Serner, Andreas, Kryger, Katrine Okholm, Brown, Natalie, Larsen, Brianna and Chibhabha, Fidelis. 2024. "Knowledge, Attitudes, and Behaviors Toward the Menstrual Cycle and Menstruation Among Elite African Women Football Players, Coaches, Health Personnel, and Referees." Women in Sport and Physical Activity Journal. 32 (1). https://doi.org/10.1123/wspaj.2023-0024
Efficacy of conservative interventions for musculoskeletal pain on disability and pain in active serving military personnel – A systematic review
Bounds, Courtney L., Coppieters, Michel W., Thomson, Hayley W., Larsen, Brianna and Evans, Kerrie. 2024. "Efficacy of conservative interventions for musculoskeletal pain on disability and pain in active serving military personnel – A systematic review." Military Medicine: international journal of AMSUS. 189 (1-2), pp. e66-e75. https://doi.org/10.1093/milmed/usac409
Moderate to Vigorous-intensity Continuous Training versus High-intensity Interval Training for improving VO2max in women: A systematic review and meta-analysis
Lindner, Robert, Selva Raj, Isaac, Yang, Angela Wei Hong, Zaman, Shadman, Larsen, Brianna and Denham, Joshua. 2023. "Moderate to Vigorous-intensity Continuous Training versus High-intensity Interval Training for improving VO2max in women: A systematic review and meta-analysis." International Journal of Sports Medicine. 44 (7), pp. 484-495. https://doi.org/10.1055/a-2044-8952
A single online education session improves menstrual cycle and hormonal contraceptive knowledge in elite female basketball players and their support staff
Larsen, B., Minahan, C., McLay-Cooke, R., Cox, K. and Bird, S.. 2022. "A single online education session improves menstrual cycle and hormonal contraceptive knowledge in elite female basketball players and their support staff." New Zealand Journal of Sports Medicine. 49 (1), pp. 16-22.
Basketball New Zealand infographic: female athlete health - Part 2: hormonal contraceptives: what are the options?
Larsen, Brianna and Bird, Stephen P.. 2021. Basketball New Zealand infographic: female athlete health - Part 2: hormonal contraceptives: what are the options? Wellington, New Zealand. Basketball New Zealand.
Basketball New Zealand infographic: female athlete health - understanding your menstrual cycle: what’s normal, what’s not?
Larsen, Brianna and Bird, Stephen. 2020. Basketball New Zealand infographic: female athlete health - understanding your menstrual cycle: what’s normal, what’s not? Wellington, New Zealand. Basketball New Zealand.
A survey to identify physically demanding tasks performed during storm damage operations by Australian State Emergency Services personnel
Larsen, Brianna, Graham, Tony and Aisbett, Brad. 2013. "A survey to identify physically demanding tasks performed during storm damage operations by Australian State Emergency Services personnel." Applied Ergonomics: human factors in technology and society. 44 (1), pp. 128-133. https://doi.org/10.1016/j.apergo.2012.05.010
Effect of heat on firefighters' work performance and physiology
Larsen, Brianna, Snow, Rodney and Aisbett, Brad. 2015. "Effect of heat on firefighters' work performance and physiology." Journal of Thermal Biology. 53, pp. 1-8. https://doi.org/10.1016/j.jtherbio.2015.07.008
Firefighter feedback during active cooling: a useful tool for heat stress management?
Savage, Robbie J., Lord, Cara, Larsen, Brianna L., Knight, Teagan L., Langridge, Peter D. and Aisbett, Brad. 2014. "Firefighter feedback during active cooling: a useful tool for heat stress management?" Journal of Thermal Biology. 46, pp. 65-71. https://doi.org/10.1016/j.jtherbio.2014.10.003
The injury profile of an Australian specialist policing unit
Larsen, Brianna, Aisbett, Brad and Silk, Aaron. 2016. "The injury profile of an Australian specialist policing unit." International Journal of Environmental Research and Public Health. 13 (4), pp. 1-9. https://doi.org/10.3390/ijerph13040370
Subjective job task analyses for physically demanding occupations: what is best practice?
Larsen, Brianna and Aisbett, Brad. 2012. "Subjective job task analyses for physically demanding occupations: what is best practice?" Ergonomics: an international journal of research and practice in human factors and ergonomics. 55 (10), pp. 1266-1277. https://doi.org/10.1080/00140139.2012.697582
Sleep restriction during simulated wildfire suppression: effect on physical task performance
Vincent, Grace, Ferguson, Sally A., Tran, Jacqueline, Larsen, Brianna, Wolkow, Alexander and Aisbett, Brad. 2015. "Sleep restriction during simulated wildfire suppression: effect on physical task performance." PLoS One. 10 (1), pp. 1-16. https://doi.org/10.1371/journal.pone.0115329
Multiple days of heat exposure on firefighters’ work performance and physiology
Larsen, Brianna, Snow, Rod, Vincent, Grace, Tran, Jacqueline, Wolkow, Alexander and Aisbett, Brad. 2015. "Multiple days of heat exposure on firefighters’ work performance and physiology." PLoS One. 10 (9), pp. 1-16. https://doi.org/10.1371/journal.pone.0136413
Simulated firefighting task performance and physiology under very hot conditions
Larsen, Brianna, Snow, Rod, Williams-Bell, Michael and Aisbett, Brad. 2015. "Simulated firefighting task performance and physiology under very hot conditions." Frontiers in Physiology. 6, pp. 1-9. https://doi.org/10.3389/fphys.2015.00322
The Impact of Heat Exposure and Sleep Restriction on Firefighters’ Work Performance and Physiology during Simulated Wildfire Suppression
Vincent, Grace E., Aisbett, Brad, Larsen, Brianna, Ridgers, Nicola D., Snow, Rod and Ferguson, Sally A.. 2017. "The Impact of Heat Exposure and Sleep Restriction on Firefighters’ Work Performance and Physiology during Simulated Wildfire Suppression." International Journal of Environmental Research and Public Health. 14 (2), pp. 1-15. https://doi.org/10.3390/ijerph14020180
Response of women using oral contraception to exercise in the heat
Minahan, Clare, Melnikoff, Marina, Quinn, Karlee and Larsen, Brianna. 2017. "Response of women using oral contraception to exercise in the heat." European Journal of Applied Physiology. 117, pp. 1383-1391. https://doi.org/10.1007/s00421-017-3628-7
The Effects of Simulated Wildland Firefighting Tasks on Core Temperature and Cognitive Function under Very Hot Conditions
Williams-Bell, F. Michael, Aisbett, Brad, Murphy, Bernadette A. and Larsen, Brianna. 2017. "The Effects of Simulated Wildland Firefighting Tasks on Core Temperature and Cognitive Function under Very Hot Conditions." Frontiers in Physiology. 8, pp. 1-10. https://doi.org/10.3389/fphys.2017.00815
Identifying and characterising the physical demands for an Australian specialist policing unit
Silk, Aaron, Savage, Robbie, Larsen, Brianna and Aisbett, Brad. 2018. "Identifying and characterising the physical demands for an Australian specialist policing unit." Applied Ergonomics: human factors in technology and society. 68, pp. 197-203. https://doi.org/10.1016/j.apergo.2017.11.012
Oral contraceptives augment the exercise pressor reflex during isometric handgrip exercise
Minahan, Clare, O'Neill, Hailey, Sikkema, Nelie, Joyce, Sarah, Larsen, Brianna and Sabapathy, Surendran. 2018. "Oral contraceptives augment the exercise pressor reflex during isometric handgrip exercise." Physiological Reports. 6 (5), pp. 1-8. https://doi.org/10.14814/phy2.13629
Immune Response in Women during Exercise in the Heat: A Spotlight on Oral Contraception
Larsen, Brianna, Cox, Amanda, Quinn, Karlee, Fisher, Rhiannon and Minahan, Clare. 2018. "Immune Response in Women during Exercise in the Heat: A Spotlight on Oral Contraception." Journal of Sports Science and Medicine. 17 (2), pp. 229-236.
Adding sleep restriction to the equation: impact on wildland firefighters’ work performance and physiology in hot conditions
Vincent, Grace E., Ferguson, Sally, Larsen, Brianna, Ridgers, Nicola D., Snow, Rod and Aisbett, Brad. 2018. "Adding sleep restriction to the equation: impact on wildland firefighters’ work performance and physiology in hot conditions." International Archives of Occupational and Environmental Health. 91, pp. 601-611. https://doi.org/10.1007/s00420-018-1304-9
The Post-Exercise Inflammatory Response to Repeated-Sprint Running in Hypoxia
Morrison, Jaime, Larsen, Brianna, Cox, Amanda J. and Minahan, Clare. 2018. "The Post-Exercise Inflammatory Response to Repeated-Sprint Running in Hypoxia." Journal of Sports Science and Medicine. 17 (4), pp. 533-538.
The effects of hydration on cognitive performance during a simulated wildfire suppression shift in temperate and hot conditions
Cvirn, Michael, Dorrian, Jillian, Smith, Bradley, Vincent, Grace, Jay, Sarah, Roach, Greg, Sargent, Charli, Larsen, Brianna, Aisbett, Brad and Ferguson, Sally. 2019. "The effects of hydration on cognitive performance during a simulated wildfire suppression shift in temperate and hot conditions." Applied Ergonomics: human factors in technology and society. 77, pp. 9-15. https://doi.org/10.1016/j.apergo.2018.12.018
Women’s Football: An Examination of Factors That Influence Movement Patterns
Griffin, Jesse, Larsen, Brianna, Horan, Sean, Keogh, Justin, Dodd, Karl, Andreatta, Melissa and Minahan, Clare. 2020. "Women’s Football: An Examination of Factors That Influence Movement Patterns." Journal of Strength and Conditioning Research. 34 (8), pp. 2384-2393. https://doi.org/10.1519/JSC.0000000000003638
Practice does not make perfect: A brief view of athletes’ knowledge on the menstrual cycle and oral contraceptives
Larsen, Brianna, Morris, Kirstin, Quinn, Karlee, Osborne, Mark and Minahan, Clare. 2020. "Practice does not make perfect: A brief view of athletes’ knowledge on the menstrual cycle and oral contraceptives." Journal of Science and Medicine in Sport. 23 (8), pp. 690-694. https://doi.org/10.1016/j.jsams.2020.02.003
Yes, rolling averages are a good way to assess training load for injury prevention. Is there a better way? Probably, but we have not seen the evidence
Drew, M. K., Blanch, P., Purdam, C. and Gabbett, T. J.. 2017. "Yes, rolling averages are a good way to assess training load for injury prevention. Is there a better way? Probably, but we have not seen the evidence." British Journal of Sports Medicine. 51 (7), pp. 618-619. https://doi.org/10.1136/bjsports-2016-096609
The impact of sleep restriction and simulated physical firefighting work on acute inflammatory stress responses
Wolkow, Alexander, Ferguson, Sally A., Vincent, Grace E., Larsen, Brianna, Aisbett, Brad and Main, Luana C.. 2015. "The impact of sleep restriction and simulated physical firefighting work on acute inflammatory stress responses." PLoS One. 10 (9), pp. 1-17. https://doi.org/10.1371/journal.pone.0138128
Task-specific effects of modular body armor
Larsen, Brianna, Netto, Kevin and Aisbett, Brad. 2014. "Task-specific effects of modular body armor." Military Medicine: international journal of AMSUS. 179 (4), pp. 428-434. https://doi.org/10.7205/MILMED-D-13-00318
Body armor, performance, and physiology during repeated high-intensity work task
Larsen, Brianna, Netto, Kevin, Skovli, Daniel, Vincs, Kim, Vu, Sarah and Aisbett, Brad. 2012. "Body armor, performance, and physiology during repeated high-intensity work task." Military Medicine: international journal of AMSUS. 177 (11), pp. 1308-1315. https://doi.org/10.7205/MILMED-D-11-00435
The effect of body armor on performance, thermal stress, and exertion: a critical review
Larsen, Brianna, Netto, Kevin and Aisbett, Brad. 2011. "The effect of body armor on performance, thermal stress, and exertion: a critical review." Military Medicine: international journal of AMSUS. 176 (11), pp. 1265-1273. https://doi.org/10.7205/MILMED-D-10-00470