Unravelling the Antibiotic Resistance: Molecular Insights and Combating Therapies
Article
Palanikumar, Preethieswari, Nathan, Bharathi, Muthusamy, Karthikeyan, M, Suganthy, Natesan, Senthil and Sampathrajan, Vellaikumar. 2025. "Unravelling the Antibiotic Resistance: Molecular Insights and Combating Therapies." Applied Biochemistry and Biotechnology. https://doi.org/10.1007/s12010-025-05182-8
| Article Title | Unravelling the Antibiotic Resistance: Molecular Insights and Combating Therapies |
|---|---|
| ERA Journal ID | 3329 |
| Article Category | Article |
| Authors | Palanikumar, Preethieswari, Nathan, Bharathi, Muthusamy, Karthikeyan, M, Suganthy, Natesan, Senthil and Sampathrajan, Vellaikumar |
| Journal Title | Applied Biochemistry and Biotechnology |
| Number of Pages | 32 |
| Year | 2025 |
| ISSN | 0273-2289 |
| 1559-0291 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1007/s12010-025-05182-8 |
| Web Address (URL) | https://link.springer.com/article/10.1007/s12010-025-05182-8 |
| Abstract | Antibiotics, the full-stop of invasive bacteria, have been used in clinical setups from unthreatening fever to massive challenging therapies. Constant dependency on medication upsurges the evasion of microbes from antibiotics contemporarily along with ecological footprint. Thus, the infested pathogen became resilient to antibiotics, disguised as multidrug-resistant bacteria (MDR), pandrug-resistant bacteria (PDR), and extensively drug-resistant bacteria (XDR). The etymology of genetic modifications and horizontal gene transfer played an external influence on the arising resurgence. Also, intrinsic parameters, such as antibiotic efflux pumps and the formation of biofilms, encouraged intense resistance to antibiotic drugs. This aggravated resistance in microbes builds up resistome in the environment due to selective pressure; thereby drastic devastation of people suffering from disastrous diseases is mournful. Since novelite approaches for broad-spectrum antibiotics against drug resistance microbes are grueling challenges in these crucial times. This scientific study has come up with neoteric methodologies to elude immediate consequences and health hazards. Inculcating ancestral treatment towards pharmacognosy as adjuvants to the prevailing hi-fi nanotechnology, phage and algal therapy, genome mining, and bioinformatics databases are the optimizing inventions for actual and prospective living. |
| Keywords | Antibiotic resistance driving mechanism; Antibiotics ; Pharmacognosy ; Resistome ; Bio-nanoparticle |
| Contains Sensitive Content | Does not contain sensitive content |
| ANZSRC Field of Research 2020 | 320599. Medical biochemistry and metabolomics not elsewhere classified |
| Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
| Byline Affiliations | Tamil Nadu Agricultural University, India |
| Centre for Crop Health | |
| School of Agriculture and Environmental Science | |
| University of Newcastle |
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