Histidine limitation alters plant development and influences the TOR network

Article


Guerin, Amandine, Levasseur, Caroline, Herger, Aline, Renggli, Dominik, Sotiropoulos, Alexandros, Kadler, Gabor, Hou, Xiaoyu, Schaufelberger, Myriam, Meyer, Christian, Wicker, Thomas, Bigler, Laurent and Ringli, Christoph. 2025. "Histidine limitation alters plant development and influences the TOR network." Journal of Experimental Botany. 76 (4), pp. 1085-1098. https://doi.org/10.1093/jxb/erae479
Article Title

Histidine limitation alters plant development and influences the TOR network

ERA Journal ID2604
Article CategoryArticle
AuthorsGuerin, Amandine, Levasseur, Caroline, Herger, Aline, Renggli, Dominik, Sotiropoulos, Alexandros, Kadler, Gabor, Hou, Xiaoyu, Schaufelberger, Myriam, Meyer, Christian, Wicker, Thomas, Bigler, Laurent and Ringli, Christoph
Journal TitleJournal of Experimental Botany
Journal Citation76 (4), pp. 1085-1098
Number of Pages14
Year2025
PublisherOxford University Press
Place of PublicationUnited Kingdom
ISSN0022-0957
1460-2431
Digital Object Identifier (DOI)https://doi.org/10.1093/jxb/erae479
Web Address (URL)https://academic.oup.com/jxb/article/76/4/1085/7926833
AbstractPlant growth depends on growth regulators, nutrient availability, and amino acid levels, all of which influence cell wall formation and cell expansion. Cell wall integrity and structures are surveyed and modified by a complex array of cell wall integrity sensors, including leucine-rich repeat (LRR)-extensins (LRXs) that bind RALF (rapid alkalinization factor) peptides with high affinity and help to compact cell walls. Expressing the Arabidopsis root hair-specific LRX1 without the extensin domain, which anchors the protein to the cell wall (LRX1 Delta E14), has a negative effect on root hair development. The mechanism of this negative effect was investigated by a suppressor screen, which led to the identification of a sune (suppressor of dominant-negative LRX1 Delta E14) mutant collection. The sune82 mutant was identified as an allele of HISN2, which encodes an enzyme essential for histidine biosynthesis. This mutation leads to reduced accumulation of histidine and an increase in several amino acids, which appears to have an effect on the TOR (target of rapamycin) network, a major controller of eukaryotic cell growth. It also represents an excellent tool to study the effects of reduced histidine levels on plant development, as it is a rare example of a viable partial loss-of-function allele in an essential biosynthetic pathway. Partial loss of function of HISN2 in sune82 results in a significant reduction in histidine content, which subsequently alters plant development and the TOR network.
KeywordsAmino acid metabolism; Arabidopsis; HISN2; histidine defciency; LRX1; LRX1ΔE14; root growth; root hair; sune82; TOR
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020310407. Host-parasite interactions
Byline AffiliationsUniversity of Zurich, Switzerland
Paris-Saclay University, France
Permalink -

https://research.usq.edu.au/item/zx221/histidine-limitation-alters-plant-development-and-influences-the-tor-network

Download files


Published Version
erae479.pdf
License: CC BY 4.0
File access level: Anyone

  • 17
    total views
  • 5
    total downloads
  • 10
    views this month
  • 2
    downloads this month

Export as

Related outputs

First reported sexual recombination between Pyrenophora teres isolates obtained from barley and barley grass
Dahanayaka, Buddhika Amarasinghe, Sotiropoulos, Alexandros G, Vaghefi, Niloofar, Poudel, Barsha and Martin, Anke. 2024. "First reported sexual recombination between Pyrenophora teres isolates obtained from barley and barley grass." Phytopathology: International Journal of the American Phytopathological Society. 114 (11), pp. 2385-2393. https://doi.org/10.1094/PHYTO-12-23-0497-R
A fictional field case study to understand the genetic basis of host-fungal pathogen interactions using the wheat powdery mildew-wheat pathosystem
Sotiropoulos, Alexandros G., Sánchez-Martín, Javier, Widrig, Victoria, Isaksson, Jonatan, Bernasconi, Zoe, Koller, Teresa, Bearth, Giulia, Herren, Gerhard, Wicker, Thomas and Keller, Beat. 2024. "A fictional field case study to understand the genetic basis of host-fungal pathogen interactions using the wheat powdery mildew-wheat pathosystem." Journal of Biological Education. 58 (5), pp. 1022-1034. https://doi.org/10.1080/00219266.2022.2147574
Mutagenesis of wheat powdery mildew reveals a single gene controlling both NLR and tandem kinase-mediated immunity
Bernasconi, Zoe, Stirnemann, Ursin, Heuberger, Matthias, Sotiropoulos, Alexandros, Graf, Johannes, Wicker, Thomas, Keller, Beat and Sánchez-Martín, Javier. 2024. "Mutagenesis of wheat powdery mildew reveals a single gene controlling both NLR and tandem kinase-mediated immunity." Molecular Plant-Microbe Interactions. 37 (3), pp. 264-276. https://doi.org/10.1094/MPMI-09-23-0136-FI
Respiratory eukaryotic virome expansion and bacteriophage deficiency characterize childhood asthma
Megremis, Spyridon, Constantinides, Bede, Xepapadaki, Paraskevi, Yap, Chuan Fu, Sotiropoulos, Alexandros G., Bachert, Claus, Finotto, Susetta, Jartti, Tuomas, Tapinos, Avraam, Vuorinen, Tytti, Andreakos, Evangelos, Robertson, David L. and Papadopoulos, Nikolaos G.. 2023. "Respiratory eukaryotic virome expansion and bacteriophage deficiency characterize childhood asthma." Scientific Reports. 13 (1). https://doi.org/10.1038/s41598-023-34730-7
A survey of lineage‐specific genes in Triticeae reveals de novo gene evolution from genomic raw material
Poretti, Manuel, Praz, Coraline R, Sotiropoulos, Alexandros G. and Wicker, Thomas. 2023. "A survey of lineage‐specific genes in Triticeae reveals de novo gene evolution from genomic raw material." Plant Direct. 7 (3), p. e484. https://doi.org/10.1002/pld3.484
The broad use of the Pm8 resistance gene in wheat resulted in hypermutation of the AvrPm8 gene in the powdery mildew pathogen
Kunz, Lukas, Sotiropoulos, Alexandros G., Graf, Johannes, Razavi, Mohammad, Keller, Beat and Müller, Marion C.. 2023. "The broad use of the Pm8 resistance gene in wheat resulted in hypermutation of the AvrPm8 gene in the powdery mildew pathogen." BMC Biology. 21 (1), p. 29. https://doi.org/10.1186/s12915-023-01513-5
Transposable element populations shed light on the evolutionary history of wheat and the complex co‐evolution of autonomous and non‐autonomous retrotransposons
Wicker, Thomas, Stritt, Christoph, Sotiropoulos, Alexandros G, Poretti, Manuel, Pozniak, Curtis, Walkowiak, Sean, Gundlach, Heidrun and Stein, Nils. 2022. "Transposable element populations shed light on the evolutionary history of wheat and the complex co‐evolution of autonomous and non‐autonomous retrotransposons." Advanced Genetics. 3 (1). https://doi.org/10.1002/ggn2.202100022
Global genomic analyses of wheat powdery mildew reveal association of pathogen spread with historical human migration and trade
Sotiropoulos, Alexandros G, Arango-Isaza, Epifanía, Ban, Tomohiro, Barbieri, Chiara, Bourras, Salim, Cowger, Christina, Czembor, Paweł C., Ben-David, Roi, Dinoor, Amos, Ellwood, Simon R., Graf, Johannes, Hatta, Koichi, Helguera, Marcelo, Sánchez-Martín, Javier, McDonald, Bruce A., Morgounov, Alexey I., Müller, Marion C., Shamanin, Vladimir, Shimizu, Kentaro K., ..., Wicker, Thomas. 2022. "Global genomic analyses of wheat powdery mildew reveal association of pathogen spread with historical human migration and trade." Nature Communications. 13 (1). https://doi.org/10.1038/s41467-022-31975-0
Ancient variation of the AvrPm17 gene in powdery mildew limits the effectiveness of the introgressed rye Pm17 resistance gene in wheat
Müller, Marion C., Kunz, Lukas, Schudel, Seraina, Lawson, Aaron W., Kammerecker, Sandrine, Isaksson, Jonatan, Wyler, Michele, Graf, Johannes, Sotiropoulos, Alexandro G.s, Praz, Coraline R., Manser, Beatrice, Wicker, Thomas, Bourras, Salim and Keller, Beat. 2022. "Ancient variation of the AvrPm17 gene in powdery mildew limits the effectiveness of the introgressed rye Pm17 resistance gene in wheat." Proceedings of the National Academy of Sciences (PNAS). 119 (30). https://doi.org/10.1073/pnas.2108808119
A global analysis of matches and mismatches between human genetic and linguistic histories
Barbieri, Chiara, Blasi, Damian E., Arango-Isaza, Epifania, Sotiropoulos, Alexandros G., Hammarstrom, Harald, Wichmann, Soren, Greenhill, Simon J., Gray, Russell D., Forkel, Robert, Bickel, Balthasar and Shimizu, Kentaro K.. 2022. "A global analysis of matches and mismatches between human genetic and linguistic histories." Proceedings of the National Academy of Sciences (PNAS). 119 (47), p. e2122084119. https://doi.org/10.1073/pnas.2122084119
Comparative transcriptome analysis of wheat lines in the field reveals multiple essential biochemical pathways suppressed by obligate pathogens
Poretti, Manuel, Sotiropoulos, Alexandros G., Graf, Johannes, Jung, Esther, Bourras, Salim, Krattinger, Simon G. and Wicker, Thomas. 2021. "Comparative transcriptome analysis of wheat lines in the field reveals multiple essential biochemical pathways suppressed by obligate pathogens." Frontiers in Plant Science. 12. https://doi.org/10.3389/fpls.2021.720462
Sawfly genomes reveal evolutionary acquisitions that fostered the mega-radiation of parasitoid and eusocial Hymenoptera
Oeyen, Jan Philip, Baa-Puyoulet, Patrice, Benoit, Joshua B., Beukeboom, Leo W., Bornberg-Bauer, Erich, Buttstedt, Anja, Calevro, Federica, Cash, Elizabeth I., Chao, Hsu, Charles, Hubert, Chen, Mei-Ju May, Childers, Christopher, Cridge, Andrew G., Dearden, Peter, Dinh, Huyen, Doddapaneni, Harsha V., Dolan, Amanda, Donath, Alexander, Dowling, Daniel, ..., Niehuis, O.. 2020. "Sawfly genomes reveal evolutionary acquisitions that fostered the mega-radiation of parasitoid and eusocial Hymenoptera." Genome Biology and Evolution. 12 (7), pp. 1099-1188. https://doi.org/10.1093/gbe/evaa106
A chromosome‐scale genome assembly reveals a highly dynamic effector repertoire of wheat powdery mildew
Müller, Marion C., Praz, Coraline R., Sotiropoulos, Alexandros G., Menardo, Fabrizio, Kunz, Lukas, Schudel, Seraina, Oberhänsli, Simone, Poretti, Manuel, Wehrli, Andreas and Bourras, Salim. 2019. "A chromosome‐scale genome assembly reveals a highly dynamic effector repertoire of wheat powdery mildew." New Phytologist. 221 (4), pp. 2176-2189. https://doi.org/10.1111/nph.15529