The anti-mutagenic properties of bile pigments

Article


Bulmer, Andrew C., Ried, K., Blanchfield, Joanne T. and Wagner, Karl-Heinz. 2008. "The anti-mutagenic properties of bile pigments." Mutation Research/Reviews in Mutation Research. 658, pp. 28-41. https://doi.org/10.1016j.mrrev.2007.05.001
Article Title

The anti-mutagenic properties of bile pigments

ERA Journal ID2403
Article CategoryArticle
AuthorsBulmer, Andrew C. (Author), Ried, K. (Author), Blanchfield, Joanne T. (Author) and Wagner, Karl-Heinz (Author)
Journal TitleMutation Research/Reviews in Mutation Research
Journal Citation658, pp. 28-41
Number of Pages14
Year2008
Place of PublicationNetherlands
ISSN1383-5742
1388-2139
Digital Object Identifier (DOI)https://doi.org/10.1016j.mrrev.2007.05.001
Abstract

Bile pigments, including bilirubin and biliverdin, are endogenous compounds belonging to the porphyrin family of molecules. In the past, bile pigments and bilirubin in particular were thought of as useless by-products of heme catabolism that can be toxic if they accumulate. However, in the past 20 years, research probing the physiological relevance of bile pigments has been mounting, with
evidence to suggest bile pigments possess significant antioxidant and anti-mutagenic properties. More specifically, bile pigments are potent peroxyl radical scavengers and inhibit the mutagenic effects of a number of classes of mutagens (polycyclic aromatic
hydrocarbons, heterocyclic amines, oxidants). Coincidentally, persons with elevated circulating bilirubin concentrations have a reduced prevalence of cancer and cardio-vascular disease. Despite the encouraging in vitro anti-mutagenic effects of bile pigments, relatively little research has been conducted on their inhibitory capacity in bacterial and cultured cell assays of mutation, which
might link the existing in vitro and in vivo observations. This is the first review to summarise the published data and it is our hope it will stimulate further research on these potentially preventative compounds.

Keywordsbilirubin; bilirubin ditaurate; biliverdin; mutagenicity; salmonella
ANZSRC Field of Research 2020420702. Exercise physiology
320199. Cardiovascular medicine and haematology not elsewhere classified
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Byline AffiliationsUniversity of Queensland
University of Vienna, Austria
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