Effects of maximal static apnea on antioxidant defenses in trained free divers

Article


Bulmer, Andrew C., Coombes, Jeff S., Sharman, James E. and Stewart, Ian B.. 2008. "Effects of maximal static apnea on antioxidant defenses in trained free divers." Medicine and Science in Sports and Exercise. 40 (7), pp. 1307-1313. https://doi.org/10.1249/MSS.0b013e31816a7188
Article Title

Effects of maximal static apnea on antioxidant defenses in trained free divers

ERA Journal ID9788
Article CategoryArticle
AuthorsBulmer, Andrew C. (Author), Coombes, Jeff S. (Author), Sharman, James E. (Author) and Stewart, Ian B. (Author)
Journal TitleMedicine and Science in Sports and Exercise
Journal Citation40 (7), pp. 1307-1313
Number of Pages7
Year2008
PublisherLippincott Williams & Wilkins
Place of PublicationUnited States
ISSN0195-9131
1530-0315
Digital Object Identifier (DOI)https://doi.org/10.1249/MSS.0b013e31816a7188
Abstract

Purpose: To investigate the effects of maximal static apnea on plasma antioxidant status, oxidative stress, and antioxidant enzyme activities in trained free divers. Methods: Blood was taken from apnea-trained (Tr) and control (Con) subjects at baseline (B) and after one (A1), three (A3), and five (A5) apneas. Trolox equivalent antioxidant capacity (TEAC), ferric reducing ability of plasma (FRAP), uric acid, and bilirubin assays assessed plasma antioxidant status and malondialdehyde (MDA) quantified the oxidative stress response. The activities of erythrocyte antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were determined at baseline and after the fifth
apnea. Results: TEAC was significantly higher in divers versus controls after A1 (P G 0.05). A group effect of SOD activity indicated higher activity throughout the protocol in Tr (mean T SD; Con, 43.2 T 10.1 UIg Hbj1; Tr, 50.1 T 7.3 UIg Hbj1; P = 0.04). With no other group differences, the groups’ data were combined. Apnea significantly increased SOD (B, 44.1 T 11.1 UIg Hbj1; A5, 48.1 T 7.5 UIg Hbj1; P G 0.05) and GPx activity (B, 60.5 T 14.9 UIg Hbj1; A5, 70.1 T 16.0 UIg Hbj1; P = 0.02); however, CAT activity
decreased (B, 5.25 T 0.59 UImg Hbj1; A5, 5.00 T 0.53 UImg Hbj1; P = 0.03). MDA was unaffected by apnea (P = 0.32). Conclusions: Trained free divers have increased SOD activity during apnea; however, there is little difference in their antioxidant and oxidative stress responses compared with controls. In both groups, acute changes in antioxidant enzyme activities suggest that they may protect from excessive antioxidant depletion and oxidative stress during apnea.

Keywordsenzymes; superoxide dismutase; glutathione peroxidase, catalase; hypoxia; breath hold
ANZSRC Field of Research 2020420702. Exercise physiology
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsUniversity of Queensland
Queensland University of Technology
Permalink -

https://research.usq.edu.au/item/9zx1v/effects-of-maximal-static-apnea-on-antioxidant-defenses-in-trained-free-divers

  • 1795
    total views
  • 8
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Active Voice: Professional Associations Collaborating to Provide Exercise is Medicine® Education for Junior Doctors in Australia
Coombes, Jeff S. and Cameron, Melainie. 2020. "Active Voice: Professional Associations Collaborating to Provide Exercise is Medicine® Education for Junior Doctors in Australia." Sports Medicine Bulletin. 17 March 2020.
Inspiratory flow-resistive breathing, respiratory muscle-induced systemic oxidative stress, and diaphragm fatigue in healthy humans
Briskey, David R., Vogel, Kurt, Johnson, Michael A., Sharpe, Graham R., Coombes, Jeff S. and Mills, Dean E.. 2020. "Inspiratory flow-resistive breathing, respiratory muscle-induced systemic oxidative stress, and diaphragm fatigue in healthy humans." Journal of Applied Physiology. 129 (1), pp. 185-193. https://doi.org/10.1152/japplphysiol.00091.2020
Searching for scientific Mozarts: get em' while they're young
Donovan, Jennifer, Haeusler, Carole and Stewart, Ian. 2013. "Searching for scientific Mozarts: get em' while they're young." The Conversation. 18 June 2013, pp. 1-4.
The effects of immunosuppressants on vascular function, systemic oxidative stress and inflammation in rats
Shing, Cecilia M., Fassett, Robert G., Brown, Lindsay and Coombes, Jeff S.. 2012. "The effects of immunosuppressants on vascular function, systemic oxidative stress and inflammation in rats." Transplant International. 25 (3), pp. 337-346. https://doi.org/10.1111/j.1432-2277.2011.01420.x
Antioxidant supplementation enhances erythrocyte antioxidant status and attenuates cyclosporine-induced vascular dysfunction
Lexis, L. A., Fenning, A., Brown, L., Fassett, R. G. and Coombes, J. S.. 2006. "Antioxidant supplementation enhances erythrocyte antioxidant status and attenuates cyclosporine-induced vascular dysfunction." American Journal of Transplantation. 6 (1), pp. 41-49. https://doi.org/10.1111/j.1600-6143.2005.01154.x
Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress
Lim, Chin Leong, Wilson, Gary, Brown, Lindsay, Coombes, Jeff S. and Mackinnon, Laurel T.. 2007. "Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress ." American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 292 (1), pp. R186-R194. https://doi.org/10.1152/ajpregu.00921.2005
Endurance exercise and DNA stability: is there a link to duration and intensity?
Reichhold, Stefanie, Neubauer, Oliver, Bulmer, Andrew C., Knasmuller, Siegfried and Wagner, Karl-Heinz. 2009. "Endurance exercise and DNA stability: is there a link to duration and intensity?" Mutation Research/Reviews in Mutation Research. 682 (1), pp. 28-38. https://doi.org/10.1016/j.mrrev.2009.02.002
Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administration
Morgan, Michael, Bulmer, Andrew C., Woodruff, Trent M., Proctor, Lavinia M., Williams, Hua M., Stocks, Shelli Z., Pollitt, Sandra, Taylor, Stephen M. and Shiels, Ian A.. 2008. "Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administration." European Journal of Pharmaceutical Sciences. 33 (4-5), pp. 390-398. https://doi.org/10.1016/j.ejps.2008.01.009
In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modifcation of biliverdin
Bulmer, Andrew C., Blanchfield, Joanne T., Coombes, Jeff S. and Toth, Istvan. 2008. "In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modifcation of biliverdin." Bioorganic and Medicinal Chemistry. 16 (7), pp. 3616-3625. https://doi.org/10.1016/j.bmc.2008.02.2008
Improved resistance to serum oxidation in Gilbert's Syndrome: a mechanism for cardiovascular protection
Bulmer, Andrew C., Blanchfield, Joanne T., Toth, Istvan, Fassett, Robert G. and Coombes, Jeff S.. 2008. "Improved resistance to serum oxidation in Gilbert's Syndrome: a mechanism for cardiovascular protection." Atherosclerosis. 199, pp. 390-396. https://doi.org/10.1016/j.atherosclerosis.2007.11.022
The anti-mutagenic properties of bile pigments
Bulmer, Andrew C., Ried, K., Blanchfield, Joanne T. and Wagner, Karl-Heinz. 2008. "The anti-mutagenic properties of bile pigments." Mutation Research/Reviews in Mutation Research. 658, pp. 28-41. https://doi.org/10.1016j.mrrev.2007.05.001
The anti-mutagenic and antioxidant effects of bile pigments in the Ames Salmonella test
Bulmer, Andrew C., Ried, K., Coombes, Jeff S., Blanchfield, Joanne T., Toth, Istvan and Wagner, Karl-Heinz. 2007. "The anti-mutagenic and antioxidant effects of bile pigments in the Ames Salmonella test." Mutation Research: Genetic Toxicology and Environmental Mutagenesis. 629, pp. 122-132. https://doi.org/10.1016/j.mrgentox.2007.01.008
Arterial oxygen desaturation kinetics during apnea
Stewart, Ian B., Bulmer, Andrew C., Sharman, James E. and Ridgway, Lynne. 2005. "Arterial oxygen desaturation kinetics during apnea." Medicine and Science in Sports and Exercise. 37 (11), pp. 1871-1876. https://doi.org/10.12490/01.mss.0000176305.51360.7e
Optimising exercise training in peripheral arterial disease
Bulmer, Andrew C. and Coombes, Jeff S.. 2004. "Optimising exercise training in peripheral arterial disease." Sports Medicine. 34 (14), pp. 983-1003. https://doi.org/10.2165/00007256-200434140-00004