In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modifcation of biliverdin
Article
Article Title | In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modifcation of biliverdin |
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ERA Journal ID | 1565 |
Article Category | Article |
Authors | Bulmer, Andrew C. (Author), Blanchfield, Joanne T. (Author), Coombes, Jeff S. (Author) and Toth, Istvan (Author) |
Journal Title | Bioorganic and Medicinal Chemistry |
Journal Citation | 16 (7), pp. 3616-3625 |
Number of Pages | 10 |
Year | 2008 |
Place of Publication | United Kingdom |
ISSN | 0968-0896 |
1464-3391 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.bmc.2008.02.2008 |
Abstract | Bile pigments, including bilirubin and biliverdin are tetrapyrrolic, dicarboxylic acids capable of forming conjugates at their propionic acid groups via ester or amide bonds. They possess substantial antioxidant and anti-mutagenic activities and therefore their intestinal absorption might influence the development of cardiovascular disease and cancer. The aim of this study was to investigate whether altering the physico-chemical properties of bile pigments would improve their permeability in an in vitro assay of absorption. Native and synthetically modified bile pigments were tested for gastrointestinal permeability and metabolic stability |
Keywords | unconjugated bilirubin; bilirubin ditaurate; amide conjugate; caco-2 cell; absorption; stability; toxicity |
ANZSRC Field of Research 2020 | 420702. Exercise physiology |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | University of Queensland |
https://research.usq.edu.au/item/9zx1z/in-vitro-permeability-and-metabolic-stability-of-bile-pigments-and-the-effects-of-hydrophilic-and-lipophilic-modifcation-of-biliverdin
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