Efficient discovery of risk patterns in medical data

Article

Li, Jiuyong, Fu, Ada Wai-chee and Fahey, Paul. 2009. "Efficient discovery of risk patterns in medical data." Artificial Intelligence in Medicine. 45 (1), pp. 77-89. https://doi.org/10.1016/j.artmed.2008.07.008
Article Title

Efficient discovery of risk patterns in medical data

ERA Journal ID5031
Article CategoryArticle
AuthorsLi, Jiuyong (Author), Fu, Ada Wai-chee (Author) and Fahey, Paul (Author)
Journal TitleArtificial Intelligence in Medicine
Journal Citation45 (1), pp. 77-89
Number of Pages13
Year2009
PublisherElsevier
Place of PublicationAmsterdam, Netherlands
ISSN0933-3657
1873-2860
Digital Object Identifier (DOI)https://doi.org/10.1016/j.artmed.2008.07.008
Web Address (URL)http://www.sciencedirect.com/science/article/pii/S0933365708000900
Abstract

Objective: This paper studies a problem of efficiently discovering risk patterns in medical data. Risk patterns are defined by a statistical metric, relative risk, which has been widely used in epidemiological research. Methods: To avoid fruitless search in the complete exploration of risk patterns, we define optimal risk pattern set to exclude superfluous patterns, i.e. complicated patterns with lower relative risk than their corresponding simpler form patterns. We prove that mining optimal risk pattern sets conforms an anti-monotone property that supports an efficient mining algorithm. We propose an efficient algorithm for mining optimal risk pattern sets based on this property. We also propose a hierarchical structure to present discovered patterns for the easy perusal by domain experts. Results: The proposed approach is compared with two well-known rule discovery methods, decision tree and association rule mining approaches on benchmark data sets and applied to a real world application. The proposed method discovers more and better quality risk patterns than a decision tree approach. The decision tree method is not designed for such applications and is inadequate for pattern exploring. The proposed method does not discover a large number of uninteresting superfluous patterns as an association mining approach does. The proposed method is more efficient than an association rule mining method. A real world case study shows that the method reveals some interesting risk patterns to medical practitioners. Conclusion: The proposed method is an efficient approach to explore risk patterns. It quickly identifies cohorts of patients that are vulnerable to a risk outcome from a large data set. The proposed method is useful for exploratory study on large medical data to generate and refine hypotheses. The method is also useful for designing medical surveillance systems.

Keywordsassociation rule; data mining; decision tree; epidemiology; relative risk; risk pattern
ANZSRC Field of Research 2020490501. Applied statistics
490502. Biostatistics
420399. Health services and systems not elsewhere classified
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Byline AffiliationsUniversity of South Australia
Chinese University of Hong Kong, China
Department of Mathematics and Computing
Institution of OriginUniversity of Southern Queensland
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