Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth (Myoporaceae)

Article

Beattie, Karren D., Waterman, Peter G., Forster, Paul I., Thompson, Dion R. and Leach, David N.. 2011. "Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth (Myoporaceae)." Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology. 72 (4-5), pp. 400-408. https://doi.org/10.1016/j.phytochem.2010.12.011
Article Title

Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth (Myoporaceae)

ERA Journal ID1371
Article CategoryArticle
AuthorsBeattie, Karren D. (Author), Waterman, Peter G. (Author), Forster, Paul I. (Author), Thompson, Dion R. (Author) and Leach, David N. (Author)
Journal TitlePhytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology
Journal Citation72 (4-5), pp. 400-408
Number of Pages9
Year2011
PublisherElsevier
Place of PublicationOxford, United Kingdom
ISSN0031-9422
1873-3700
Digital Object Identifier (DOI)https://doi.org/10.1016/j.phytochem.2010.12.011
Abstract

A detailed investigation of the wood, leaf, branch and root oil of Eremophila mitchellii (Benth.) was carried out by a combination of GC–FID, GC–MS and NMR. The wood oil was composed predominantly of eremophilanes, a rare class of biologically active, bicyclic sesquiterpenoids. The root oil was also found to contain the eremophilanes together with the zizaene sesquiterpene, sesquithuriferone. 9-Hydroxy-1,7(11),9-eremophilatrien-8-one and the known 1(10),11-eremophiladien-9-one (eremophilone), 9-hydroxy-7(11),9-eremophiladien-8-one (2-hydroxyeremophilone), 8-hydroxy-11-eremophilen-9-one (santalcamphor), 8-hydroxy-10,11-eremophiladien-9-one, sesquithuriferone and 8-hydroxy-1,11-eremophiladien-9-one were purified and elucidated by NMR. Three approaches to the purification of the major eremophilanes from the wood oil are described. (+) Spathulenol, α-pinene, globulol, viridiflorene were the major constituents of the leaf oil. All of the essential oils and the eremophilanes exhibited cytotoxicity against P388D1 mouse lymphoblast cells in-vitro.

KeywordsEremophila mitchellii; Myoporaceae; Cytotoxic; Sesquiterpene; Eremophilane; essential oil; Eremophilone; Santalcamphor; wood oil
ANZSRC Field of Research 2020340399. Macromolecular and materials chemistry not elsewhere classified
340401. Biologically active molecules
340502. Natural products and bioactive compounds
Public Notes

© 2011 Elsevier Ltd. Restricted access in accordance with the publisher copyright policy.

Byline AffiliationsSouthern Cross University
Queensland Herbarium, Australia
Institution of OriginUniversity of Southern Queensland
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