Austrocolorone B and Austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini

Article


Beattie, Karren D., Thompson, Dion R., Tiralongo, Evelin, Ratkowsky, David, May, Tom W. and Gill, Melvyn. 2011. "Austrocolorone B and Austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini." Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry. 52 (42), pp. 5448-5451. https://doi.org/10.1016/j.tetlet.2011.08.015
Article Title

Austrocolorone B and Austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini

ERA Journal ID1602
Article CategoryArticle
AuthorsBeattie, Karren D. (Author), Thompson, Dion R. (Author), Tiralongo, Evelin (Author), Ratkowsky, David (Author), May, Tom W. (Author) and Gill, Melvyn (Author)
Journal TitleTetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry
Journal Citation52 (42), pp. 5448-5451
Number of Pages4
Year2011
Place of PublicationKidlington, OX. United Kingdom
ISSN0040-4039
1873-3581
Digital Object Identifier (DOI)https://doi.org/10.1016/j.tetlet.2011.08.015
Abstract

The yellow dihydroanthracenone dimer, austrocolorin B1 and the unique violet-red 1,4-anthraquinone dimer, austrocolorone B, were isolated from the Tasmanian mushroom Cortinarius vinosipes and their structures and stereochemistry were determined from spectroscopic data. Austrocolorin B1 and austrocolorone B were found to exhibit potent cytotoxic activity in vitro against the murine lymphoblast (P388D1) cell line with IC50 values in the range 10–31 lg/mL.

KeywordsCytotoxic; Anthraquinone; Tricolorin; Australian fungi
ANZSRC Field of Research 2020340399. Macromolecular and materials chemistry not elsewhere classified
340401. Biologically active molecules
340502. Natural products and bioactive compounds
321105. Chemotherapy
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Byline AffiliationsUniversity of Melbourne
Southern Cross University
Griffith University
University of Tasmania
Royal Botanic Gardens, Melbourne, Australia
Institution of OriginUniversity of Southern Queensland
Funding source
Australian Research Council (ARC)
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