Antibacterial metabolites from Australian macrofungi from the genus Cortinarius

Article

Beattie, Karren D., Rouf, Razina, Gander, Louisa, May, Tom W., Ratkowsky, David, Donner, Christopher D., Gill, Melvyn, Grice, I. Darren and Tiralongo, Evelin. 2010. "Antibacterial metabolites from Australian macrofungi from the genus Cortinarius." Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology. 71 (8-9), pp. 948-955. https://doi.org/10.1016/j.phytochem.2010.03.016
Article Title

Antibacterial metabolites from Australian macrofungi from the genus Cortinarius

ERA Journal ID1371
Article CategoryArticle
AuthorsBeattie, Karren D. (Author), Rouf, Razina (Author), Gander, Louisa (Author), May, Tom W. (Author), Ratkowsky, David (Author), Donner, Christopher D. (Author), Gill, Melvyn (Author), Grice, I. Darren (Author) and Tiralongo, Evelin (Author)
Journal TitlePhytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology
Journal Citation71 (8-9), pp. 948-955
Number of Pages8
Year2010
PublisherElsevier
Place of PublicationKidlington, OX. United Kingdom
ISSN0031-9422
1873-3700
Digital Object Identifier (DOI)https://doi.org/10.1016/j.phytochem.2010.03.016
Abstract

In this study, ethyl acetate and aqueous fractions from 117 collections of Australian macrofungi belonging to the mushroom genus Cortinarius were screened for antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Overall, the lipophilic fractions were more active than the aqueous fractions. The ethyl acetate fractions of most or all collections of 13 species, namely Cortinarius ardesiacus, C. archeri, C. austrosaginus, C. austrovenetus, C. austroviolaceus, C. coelopus, C. [Dermocybecanaria] 2, C. clelandii, C. [D. kula], C. memoria-annae, C. persplendidus, C. sinapicolor, C. vinosipes and forty seven collections of un-described Cortinarius species exhibited IC50 values of ⩽0.09 mg/mL against S. aureus. In contrast, most or all collections of only four species, namely C. abnormis, C. austroalbidus, C. [D. kula], C. persplendidus, and eleven un-described Cortinarius collections exhibited similar effects against P. aeruginosa (IC50 ⩽ 0.09 mg/mL). Anthraquinonoid pigments isolated from C. basirubescens together with emodin physcion and erythrogluacin were assessed for their antimicrobial activity. The fungal octaketides austrocortilutein, austrocortirubin, torosachrysone, physcion and emodin were found to strongly inhibit the growth of S. aureus (IC50 0.7–12 μg/mL) whereas only physcion and emodin exhibited potency against P. aeruginosa (IC50 1.5 and 2.0 μg/mL, respectively).

KeywordsCortinarius basirubescens; Cortinarius; Dermocybe; Australian fungi; antimicrobial; antibacterial; Staphylococcus aureus; Pseudomonas aeruginosa; pigments; Anthraquinones
ANZSRC Field of Research 2020321405. Pharmaceutical sciences
340401. Biologically active molecules
340502. Natural products and bioactive compounds
Public Notes

Files associated with this item cannot be displayed due to copyright restrictions.

Byline AffiliationsGriffith University
Royal Botanic Gardens, Melbourne, Australia
University of Tasmania
University of Melbourne
Institution of OriginUniversity of Southern Queensland
Permalink -

https://research.usq.edu.au/item/q2896/antibacterial-metabolites-from-australian-macrofungi-from-the-genus-cortinarius

Log in to edit
  • 2040
    total views
  • 34
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Export as

Related outputs

Seven new Serendipita species associated with Australian terrestrial orchids
Oktalira, Fitria T., May, Tom W., Dearnaley, John D. W. and Linde, Celeste C.. 2021. "Seven new Serendipita species associated with Australian terrestrial orchids." Mycologia. 113 (5), pp. 968-987. https://doi.org/10.1080/00275514.2021.1919848
Fungal Planet description sheets: 1112–1181
Crous, P. W., Cowan, D. A., Maggs-Kolling, G., Yilmaz, N., Larsson, E., Angelini, C., Brandrud, T. E., Dearnaley, J. D. W., Dima, B., Dovana, F., Fechner, N., Garcia, D., Gene, J., Halling, R. E., Houbraken, J., Leonard, P., Luangsa-ard, J. J., Noisripoom, W., Rea-Ireland, A. E., ..., Groenewald, J. Z.. 2020. "Fungal Planet description sheets: 1112–1181." Persoonia. 45, pp. 251-409. https://doi.org/10.3767/persoonia.2020.45.10
The discovery, synthesis and antimalarial evaluation of natural product ​based polyamine alkaloids
Choomuenwai, Vanida, Schwartz, Brett D., Beattie, Karren D., Andrews, Katherine T., Khokhar, Shahan and Davis, Rohan A.. 2013. "The discovery, synthesis and antimalarial evaluation of natural product ​based polyamine alkaloids." Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry. 54 (38), pp. 5188-5191. https://doi.org/10.1016/j.tetlet.2013.07.058
Austrocolorone B and Austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini
Beattie, Karren D., Thompson, Dion R., Tiralongo, Evelin, Ratkowsky, David, May, Tom W. and Gill, Melvyn. 2011. "Austrocolorone B and Austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini." Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry. 52 (42), pp. 5448-5451. https://doi.org/10.1016/j.tetlet.2011.08.015
Global diversity and geography of soil fungi
Tedersoo, Leho, Bahram, Mohammad, Polme, Sergei, Koljalg, Urmas, Yorou, Nourou S., Wijesundera, Ravi, Ruiz, Luis Villarreal, Vasco-Palacios, Aida M., Thu, Pham Quang, Suija, Ave, Smith, Matthew E., Sharp, Cathy, Saluveer, Erki, Saitta, Alessandro, Rosas, Miguel, Riit, Taavi, Ratkowsky, David, Pritsch, Karin, Poldmaa, Kadri, ..., Abarenkov, Kessy. 2014. "Global diversity and geography of soil fungi." Science. 346 (6213), pp. 1078-1087. https://doi.org/10.1126/science.1256688
Solving the supply of Resveratrol Tetramers from Papua New Guinean rainforest Anisoptera species (Dipterocarpaceae) that inhibit bacterial type III secretion systems
Davis, Rohan A., Beattie, Karren D., Xu, Min, Yang, Xinzhou, Yin, Sheng, Holla, Harish, Healy, Peter C., Sykes, Melissa, Shelper, Todd, Avery, Vicky M., Elofsson, Mikael, Sundin, Charlotta and Quinn, Ronald. 2014. "Solving the supply of Resveratrol Tetramers from Papua New Guinean rainforest Anisoptera species (Dipterocarpaceae) that inhibit bacterial type III secretion systems." Journal of Natural Products. 77 (12), pp. 2633-2640. https://doi.org/10.1021/np500433z
Phytochemical studies and bioactivity of Centipeda and Eremophila species
Beattie, Karren D.. 2009. Phytochemical studies and bioactivity of Centipeda and Eremophila species. PhD Thesis Doctor of Philosophy. Southern Cross University.
Isolation, structure determination and cytotoxicity studies of tryptophan alkaloids from an Australian marine sponge Hyrtios sp.
Khokhar, Shahan, Feng, Yunjiang, Campitelli, Mark R., Ekins, Merrick G., Hooper, John N. A., Beattie, Karren D., Sadowski, Martin C., Nelson, Colleen C. and Davis, Rohan A.. 2014. "Isolation, structure determination and cytotoxicity studies of tryptophan alkaloids from an Australian marine sponge Hyrtios sp." Bioorganic and Medicinal Chemistry Letters. 24 (15), pp. 3329-3332. https://doi.org/10.1016/j.bmcl.2014.05.104
(3R,4S,5S,8S,10R,13R)-3-Hydroxykaura-9(11),16-dien-18-oic acid
Beattie, Karren D., Bhadbhade, Mohan M., Craig, Donald C. and Leach, David N.. 2012. "(3R,4S,5S,8S,10R,13R)-3-Hydroxykaura-9(11),16-dien-18-oic acid." Acta Crystallographica Section E: Crystallographic Communications. 68 (2), pp. o526-o527. https://doi.org/10.1107/S1600536812002206
(2S,3S)-sulfated pterosin C, a cytotoxic sesquiterpene from the Bangladeshi mangrove fern Acrostichum aureum
Uddin, Shaikh J., Jason, Tracey L. H., Beattie, Karren D., Grice, I. Darren and Tiralongo, Evelin. 2011. "(2S,3S)-sulfated pterosin C, a cytotoxic sesquiterpene from the Bangladeshi mangrove fern Acrostichum aureum." Journal of Natural Products. 74 (9), pp. 2010-2013. https://doi.org/10.1021/np2004598
Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth (Myoporaceae)
Beattie, Karren D., Waterman, Peter G., Forster, Paul I., Thompson, Dion R. and Leach, David N.. 2011. "Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth (Myoporaceae)." Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology. 72 (4-5), pp. 400-408. https://doi.org/10.1016/j.phytochem.2010.12.011
Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro
Beattie, Karren D., Ulrich, Rahel, Grice, I. Darren, Uddin, Shaikh, Blake, Tony B., Wood, Kyle A., Steele, Jules, Iu, Fontaine, May, Tom W. and Tiralongo, Evelin. 2011. "Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro." Mycologia. 103 (3), pp. 458-465. https://doi.org/10.3852/10-121
Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis
Levrier, Claire, Balastrier, Melodie, Beattie, Karren D., Carroll, Anthony R., Martin, Frederic, Choomuenwai, Vanida and Davis, Rohan A.. 2013. "Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis." Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology. 86, pp. 121-126. https://doi.org/10.1016/j.phytochem.2012.09.019
Biologically active compounds isolated from Centipeda and their biological activity as antioxidant and antiinflammatory agents
Leach, David N., Stevenson, Lesley, Gabriel, Brigitte and Beattie, Karren. 2012. Biologically active compounds isolated from Centipeda and their biological activity as antioxidant and antiinflammatory agents. WO 2007062468 A1 Jun 7, 2007 WO 2006-AU1812 Nov 29, 2006NZ 594754 A Mar 28, 2013 NZ 2006-594754 Nov 26, 2006AU 2006319748 A1 Jun 7, 2007 AU 2006-319748 Nov 29, 2006AU 2006319748 B2 Sep 8, 2011 CA 2631127 A1 Jun 7, 2007 CA 2006-2631127 Nov 29, 2006EP 1963350 A1 Sep 3, 2008 EP 2006-817561 Nov 29, 2006NZ 568704 A Nov 25, 2011 NZ 2006-568704 Nov 29, 2006US 20090221517 A1 Sep 3, 2009 US 2009-85741 Mar 18, 2009US 8299119 B2 Oct 30, 2012