Antibacterial metabolites from Australian macrofungi from the genus Cortinarius
Article
Article Title | Antibacterial metabolites from Australian macrofungi from the genus Cortinarius |
---|---|
ERA Journal ID | 1371 |
Article Category | Article |
Authors | Beattie, Karren D. (Author), Rouf, Razina (Author), Gander, Louisa (Author), May, Tom W. (Author), Ratkowsky, David (Author), Donner, Christopher D. (Author), Gill, Melvyn (Author), Grice, I. Darren (Author) and Tiralongo, Evelin (Author) |
Journal Title | Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology |
Journal Citation | 71 (8-9), pp. 948-955 |
Number of Pages | 8 |
Year | 2010 |
Publisher | Elsevier |
Place of Publication | Kidlington, OX. United Kingdom |
ISSN | 0031-9422 |
1873-3700 | |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.phytochem.2010.03.016 |
Abstract | In this study, ethyl acetate and aqueous fractions from 117 collections of Australian macrofungi belonging to the mushroom genus Cortinarius were screened for antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Overall, the lipophilic fractions were more active than the aqueous fractions. The ethyl acetate fractions of most or all collections of 13 species, namely Cortinarius ardesiacus, C. archeri, C. austrosaginus, C. austrovenetus, C. austroviolaceus, C. coelopus, C. [Dermocybecanaria] 2, C. clelandii, C. [D. kula], C. memoria-annae, C. persplendidus, C. sinapicolor, C. vinosipes and forty seven collections of un-described Cortinarius species exhibited IC50 values of ⩽0.09 mg/mL against S. aureus. In contrast, most or all collections of only four species, namely C. abnormis, C. austroalbidus, C. [D. kula], C. persplendidus, and eleven un-described Cortinarius collections exhibited similar effects against P. aeruginosa (IC50 ⩽ 0.09 mg/mL). Anthraquinonoid pigments isolated from C. basirubescens together with emodin physcion and erythrogluacin were assessed for their antimicrobial activity. The fungal octaketides austrocortilutein, austrocortirubin, torosachrysone, physcion and emodin were found to strongly inhibit the growth of S. aureus (IC50 0.7–12 μg/mL) whereas only physcion and emodin exhibited potency against P. aeruginosa (IC50 1.5 and 2.0 μg/mL, respectively). |
Keywords | Cortinarius basirubescens; Cortinarius; Dermocybe; Australian fungi; antimicrobial; antibacterial; Staphylococcus aureus; Pseudomonas aeruginosa; pigments; Anthraquinones |
ANZSRC Field of Research 2020 | 321405. Pharmaceutical sciences |
340401. Biologically active molecules | |
340502. Natural products and bioactive compounds | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Griffith University |
Royal Botanic Gardens, Melbourne, Australia | |
University of Tasmania | |
University of Melbourne | |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q2896/antibacterial-metabolites-from-australian-macrofungi-from-the-genus-cortinarius
2062
total views34
total downloads1
views this month0
downloads this month