Antibacterial metabolites from Australian macrofungi from the genus Cortinarius

Article


Beattie, Karren D., Rouf, Razina, Gander, Louisa, May, Tom W., Ratkowsky, David, Donner, Christopher D., Gill, Melvyn, Grice, I. Darren and Tiralongo, Evelin. 2010. "Antibacterial metabolites from Australian macrofungi from the genus Cortinarius." Phytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology. 71 (8-9), pp. 948-955. https://doi.org/10.1016/j.phytochem.2010.03.016
Article Title

Antibacterial metabolites from Australian macrofungi from the genus Cortinarius

ERA Journal ID1371
Article CategoryArticle
AuthorsBeattie, Karren D. (Author), Rouf, Razina (Author), Gander, Louisa (Author), May, Tom W. (Author), Ratkowsky, David (Author), Donner, Christopher D. (Author), Gill, Melvyn (Author), Grice, I. Darren (Author) and Tiralongo, Evelin (Author)
Journal TitlePhytochemistry: the international journal of plant chemistry, plant biochemistry and molecular biology
Journal Citation71 (8-9), pp. 948-955
Number of Pages8
Year2010
PublisherElsevier
Place of PublicationKidlington, OX. United Kingdom
ISSN0031-9422
1873-3700
Digital Object Identifier (DOI)https://doi.org/10.1016/j.phytochem.2010.03.016
Abstract

In this study, ethyl acetate and aqueous fractions from 117 collections of Australian macrofungi belonging to the mushroom genus Cortinarius were screened for antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Overall, the lipophilic fractions were more active than the aqueous fractions. The ethyl acetate fractions of most or all collections of 13 species, namely Cortinarius ardesiacus, C. archeri, C. austrosaginus, C. austrovenetus, C. austroviolaceus, C. coelopus, C. [Dermocybecanaria] 2, C. clelandii, C. [D. kula], C. memoria-annae, C. persplendidus, C. sinapicolor, C. vinosipes and forty seven collections of un-described Cortinarius species exhibited IC50 values of ⩽0.09 mg/mL against S. aureus. In contrast, most or all collections of only four species, namely C. abnormis, C. austroalbidus, C. [D. kula], C. persplendidus, and eleven un-described Cortinarius collections exhibited similar effects against P. aeruginosa (IC50 ⩽ 0.09 mg/mL). Anthraquinonoid pigments isolated from C. basirubescens together with emodin physcion and erythrogluacin were assessed for their antimicrobial activity. The fungal octaketides austrocortilutein, austrocortirubin, torosachrysone, physcion and emodin were found to strongly inhibit the growth of S. aureus (IC50 0.7–12 μg/mL) whereas only physcion and emodin exhibited potency against P. aeruginosa (IC50 1.5 and 2.0 μg/mL, respectively).

KeywordsCortinarius basirubescens; Cortinarius; Dermocybe; Australian fungi; antimicrobial; antibacterial; Staphylococcus aureus; Pseudomonas aeruginosa; pigments; Anthraquinones
ANZSRC Field of Research 2020321405. Pharmaceutical sciences
340401. Biologically active molecules
340502. Natural products and bioactive compounds
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Byline AffiliationsGriffith University
Royal Botanic Gardens, Melbourne, Australia
University of Tasmania
University of Melbourne
Institution of OriginUniversity of Southern Queensland
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