Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro

Article


Beattie, Karren D., Ulrich, Rahel, Grice, I. Darren, Uddin, Shaikh, Blake, Tony B., Wood, Kyle A., Steele, Jules, Iu, Fontaine, May, Tom W. and Tiralongo, Evelin. 2011. "Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro." Mycologia. 103 (3), pp. 458-465. https://doi.org/10.3852/10-121
Article Title

Ethanolic and aqueous extracts derived from Australian
fungi inhibit cancer cell growth in vitro

ERA Journal ID2502
Article CategoryArticle
AuthorsBeattie, Karren D. (Author), Ulrich, Rahel (Author), Grice, I. Darren (Author), Uddin, Shaikh (Author), Blake, Tony B. (Author), Wood, Kyle A. (Author), Steele, Jules (Author), Iu, Fontaine (Author), May, Tom W. (Author) and Tiralongo, Evelin (Author)
Journal TitleMycologia
Journal Citation103 (3), pp. 458-465
Number of Pages8
Year2011
Place of PublicationLawrence, KS, USA
ISSN0027-5514
1557-2536
Digital Object Identifier (DOI)https://doi.org/10.3852/10-121
Abstract

Fifteen Australian macrofungi were investigated for cytotoxic activity. Ethanol, cold and hot water extracts of each species were screened for cytotoxic activity against normal mouse fibroblast cells (NIH/3T3), healthy human epithelial kidney cells (HEK-293), four cancer cell lines, gastric adenocarcinoma cells (AGS), two mammary gland adenocarcinoma cells (MDA-MB-231, MCF7) and colorectal adenocarcinoma cells (HT-29) with a validated MTT assay. Most extracts derived from Omphalotus nidiformis, Cordyceps cranstounii and Cordyceps gunnii demonstrated significant cytotoxic activity toward a variety of cancer cell lines. In contrast only some extracts from Coprinus comatus, Cordyceps hawkesii, Hypholoma fasciculare, Lepista nuda, Leratiomyces ceres and Ophiocordyceps robertsii displayed significant cytotoxic activity, which was usually selective for only one or two cancer cell lines tested. The least cytotoxic species evaluated in this study were Agaricus bitorquis, Coprinopsis atrametaria, Psathyrella asperospora, Russula clelandii, Tricholoma sp. AU2 and Xerula mundroola.

Keywordsbioactivity, Coprinus, Cordyceps, cytotoxic,drug discovery, Hypholoma, Lepista, Leratiomyces,macrofungi, Omphalotus, Ophiocordyceps
ANZSRC Field of Research 2020321405. Pharmaceutical sciences
310705. Mycology
340401. Biologically active molecules
321407. Toxicology (incl. clinical toxicology)
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Byline AffiliationsGriffith University
Royal Botanic Gardens, Melbourne, Australia
Institution of OriginUniversity of Southern Queensland
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