Human pilot studies reveal the potential of a vitronectin: growth factor complex as a treatment for chronic wounds

Article


Upton, Zee, Wallace, Hilary J., Shooter, Gary K., van Lonkhuyzen, Derek R., Yeoh-Ellerton, Sim, Rayment, Erin A., Fleming, Jacqui M., Broszczak, Daniel, Queen, Douglas, Sibbald, R. Gary, Leavesley, David I. and Stacey, Michael C.. 2011. "Human pilot studies reveal the potential of a vitronectin: growth factor complex as a treatment for chronic wounds." International Wound Journal. 8 (5), pp. 522-532. https://doi.org/10.1111/j.1742-481X.2011.00859.x
Article Title

Human pilot studies reveal the potential of a vitronectin: growth factor complex as a treatment for chronic wounds

ERA Journal ID30447
Article CategoryArticle
AuthorsUpton, Zee (Author), Wallace, Hilary J. (Author), Shooter, Gary K. (Author), van Lonkhuyzen, Derek R. (Author), Yeoh-Ellerton, Sim (Author), Rayment, Erin A. (Author), Fleming, Jacqui M. (Author), Broszczak, Daniel (Author), Queen, Douglas (Author), Sibbald, R. Gary (Author), Leavesley, David I. (Author) and Stacey, Michael C. (Author)
Journal TitleInternational Wound Journal
Journal Citation8 (5), pp. 522-532
Number of Pages11
Year2011
Place of PublicationChichester, West Sussex. United Kingdom
ISSN1742-4801
1742-481X
Digital Object Identifier (DOI)https://doi.org/10.1111/j.1742-481X.2011.00859.x
Web Address (URL)http://onlinelibrary.wiley.com/doi/10.1111/j.1742-481X.2011.00859.x/pdf
Abstract

Several different advanced treatments have been used to improve healing in chronic wounds, but none have shown sustained success. The application of topical growth factors (GFs) has displayed some potential, but the varying results, high doses and high costs have limited their widespread adoption. Many treatments have ignored the evidence that wound healing is driven by interactions between extracellular matrix proteins and GFs, not just GFs alone. We report herein that a clinical Good Manufacturing Practice-grade vitronectin:growth factor (cVN:GF) complex is able to stimulate functions relevant to wound repair in vitro, such as enhanced cellular proliferation and migration. Furthermore, we assessed this complex as a topical wound healing agent in a single-arm pilot study using venous leg ulcers, as well as several 'difficult to heal' case studies. The cVN:GF complex was safe and re-epithelialisation was observed in all but 1 of the 30 patients in the pilot study. In addition, the case studies show that this complex may be applied to several ulcer aetiologies, such as venous leg ulcers, diabetic foot ulcers and pressure ulcers. These findings suggest that further evaluation is warranted to determine whether the cVN:GF complex may be an effective topical treatment for chronic wounds.

Keywordschronic wound; growth factors; topical treatment; wound healing; Vitronectin
ANZSRC Field of Research 2020310102. Cell development, proliferation and death
320702. Medical infection agents (incl. prions)
321402. Clinical pharmacology and therapeutics
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Byline AffiliationsQueensland University of Technology
University of Western Australia
Wounds Canada
University of Toronto, Canada
Institution of OriginUniversity of Southern Queensland
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