Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer
Article
Article Title | Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer |
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ERA Journal ID | 15829 |
Article Category | Article |
Authors | Rayment, E. A. (Author), Upton, Z. (Author) and Shooter, G. K. (Author) |
Journal Title | British Journal of Dermatology |
Journal Citation | 158 (5), pp. 951-961 |
Number of Pages | 11 |
Year | 2008 |
Place of Publication | Chichester, West Sussex. United Kingdom |
ISSN | 0007-0963 |
1365-2133 | |
Digital Object Identifier (DOI) | https://doi.org/10.1111/j.1365-2133.2008.08462.x |
Web Address (URL) | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2133.2008.08462.x/pdf |
Abstract | Background: The pathology of chronic wounds is often characterized by elevated levels of proinflammatory cytokines [e.g. tumour necrosis factor (TNF)-α and interleukin (IL)-1β], proteases [e.g. matrix metalloproteinases (MMPs)] and neutrophil elastase. MMPs specifically have been implicated by a number of studies as the major protease family responsible for the degradation of key factors critical to the ulcer's ability to heal. Objectives: To assess individual MMPs in chronic wound fluid (CWF) in order to develop improved treatments for chronic ulcers. |
Keywords | chronic leg ulcer; gelatinase-B; matrix metalloproteinase; wound healing |
ANZSRC Field of Research 2020 | 320199. Cardiovascular medicine and haematology not elsewhere classified |
320220. Pathology (excl. oral pathology) | |
320701. Medical bacteriology | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Queensland University of Technology |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q2v80/increased-matrix-metalloproteinase-9-mmp-9-activity-observed-in-chronic-wound-fluid-is-related-to-the-clinical-severity-of-the-ulcer
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