Precision manufacturing for clinical-quality regenerative medicines
Article
Article Title | Precision manufacturing for clinical-quality regenerative medicines |
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ERA Journal ID | 39720 |
Article Category | Article |
Authors | Williams, David J. (Author), Thomas, Robert J. (Author), Hourd, Paul C. (Author), Chandra, Amit (Author), Ratcliffe, Elizabeth (Author), Liu, Yang (Author), Rayment, Erin A. (Author) and Archer, J. Richard (Author) |
Journal Title | Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences |
Journal Citation | 370 (1973), pp. 3924-3949 |
Number of Pages | 26 |
Year | 2012 |
Place of Publication | London, United Kingdom |
ISSN | 1364-503X |
1471-2962 | |
Digital Object Identifier (DOI) | https://doi.org/10.1098/rsta.2011.0049 |
Web Address (URL) | http://rsta.royalsocietypublishing.org/content/370/1973/3924 |
Abstract | Innovations in engineering applied to healthcare make a significant difference to people's lives. Market growth is guaranteed by demographics. Regulation and requirements for good manufacturing practice-extreme levels of repeatability and reliability-demand high-precision process and measurement solutions. Emerging technologies using living biological materials add complexity. This paper presents some results of work demonstrating the precision automated manufacture of living materials, particularly the expansion of populations of human stem cells for therapeutic use as regenerative medicines. The paper also describes quality engineering techniques for precision process design and improvement, and identifies the requirements for manufacturing technology and measurement systems evolution for such therapies. |
Keywords | automation; characterization; manufacturing; regenerative medicine; stem cells |
ANZSRC Field of Research 2020 | 401412. Precision engineering |
320606. Regenerative medicine (incl. stem cells) | |
350715. Quality management | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Loughborough University, United Kingdom |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q2v78/precision-manufacturing-for-clinical-quality-regenerative-medicines
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