Review: finding the culprit: a review of the influences of proteases on the chronic wound environment
Article
Article Title | Review: finding the culprit: a review of the influences of proteases on the chronic wound environment |
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ERA Journal ID | 35158 |
Article Category | Article |
Authors | Rayment, Erin A. (Author) and Upton, Zee (Author) |
Journal Title | International Journal of Lower Extremity Wounds |
Journal Citation | 8 (1), pp. 19-27 |
Number of Pages | 9 |
Year | 2009 |
Place of Publication | Thousand Oaks, CA. United States |
ISSN | 1534-7346 |
1552-6941 | |
Digital Object Identifier (DOI) | https://doi.org/10.1177/1534734609331596 |
Web Address (URL) | http://ijl.sagepub.com/content/8/1/19.full.pdf+html |
Abstract | Chronic leg ulcers are a complex medical condition with varied underlying causes and requiring diverse treatment strategies. It is generally accepted that chronic ulcers occur when the normal wound healing process is interrupted. These wounds are characterized by excessive protease activity, abundant granulation tissue, and decreased levels of growth factors, resulting in an overall poor prognosis for the patient. Many studies have focused on identifying the key proteases, specifically matrix metalloproteinases (MMPs), responsible for an ulcer's chronicity. Of note, the results of these studies are often conflicting. This report therefore focuses on a review of this literature to identify which MMPs are important in terms of ulcer prognosis and healing outcome. This has revealed that MMPs are clearly important in many biological processes in wound healing, hence are critical to consider when developing improved therapies to enhance both ulcer healing times and ulcer healing outcomes. |
Keywords | chronic leg ulcer; matrix metalloproteinase; wound healing |
ANZSRC Field of Research 2020 | 320803. Systems physiology |
320606. Regenerative medicine (incl. stem cells) | |
320701. Medical bacteriology | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Byline Affiliations | Queensland University of Technology |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q2v7z/review-finding-the-culprit-a-review-of-the-influences-of-proteases-on-the-chronic-wound-environment
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