Review: finding the culprit: a review of the influences of proteases on the chronic wound environment

Article


Rayment, Erin A. and Upton, Zee. 2009. "Review: finding the culprit: a review of the influences of proteases on the chronic wound environment." International Journal of Lower Extremity Wounds. 8 (1), pp. 19-27. https://doi.org/10.1177/1534734609331596
Article Title

Review: finding the culprit: a review of the influences of proteases on the chronic wound environment

ERA Journal ID35158
Article CategoryArticle
AuthorsRayment, Erin A. (Author) and Upton, Zee (Author)
Journal TitleInternational Journal of Lower Extremity Wounds
Journal Citation8 (1), pp. 19-27
Number of Pages9
Year2009
Place of PublicationThousand Oaks, CA. United States
ISSN1534-7346
1552-6941
Digital Object Identifier (DOI)https://doi.org/10.1177/1534734609331596
Web Address (URL)http://ijl.sagepub.com/content/8/1/19.full.pdf+html
Abstract

Chronic leg ulcers are a complex medical condition with varied underlying causes and requiring diverse treatment strategies. It is generally accepted that chronic ulcers occur when the normal wound healing process is interrupted. These wounds are characterized by excessive protease activity, abundant granulation tissue, and decreased levels of growth factors, resulting in an overall poor prognosis for the patient. Many studies have focused on identifying the key proteases, specifically matrix metalloproteinases (MMPs), responsible for an ulcer's chronicity. Of note, the results of these studies are often conflicting. This report therefore focuses on a review of this literature to identify which MMPs are important in terms of ulcer prognosis and healing outcome. This has revealed that MMPs are clearly important in many biological processes in wound healing, hence are critical to consider when developing improved therapies to enhance both ulcer healing times and ulcer healing outcomes.

Keywordschronic leg ulcer; matrix metalloproteinase; wound healing
ANZSRC Field of Research 2020320803. Systems physiology
320606. Regenerative medicine (incl. stem cells)
320701. Medical bacteriology
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Byline AffiliationsQueensland University of Technology
Institution of OriginUniversity of Southern Queensland
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