Non-alcoholic fatty liver disease in a rural, physically active, low income population in Sri Lanka

Article


Pinidiyapathirage, M. Janani, Dessanayake, Anuradha S., Rajindrajith, Shaman, Kalubowila, Udaya, Kato, Norihiro, Wickremasinghe, A. Rajitha and de Silva, H. Janaka. 2011. "Non-alcoholic fatty liver disease in a rural, physically active, low income population in Sri Lanka." BMC Research Notes. 4, pp. 1-5. https://doi.org/10.1186/1756-0500-4-513
Article Title

Non-alcoholic fatty liver disease in a rural, physically active, low income population in Sri Lanka

ERA Journal ID42229
Article CategoryArticle
AuthorsPinidiyapathirage, M. Janani (Author), Dessanayake, Anuradha S. (Author), Rajindrajith, Shaman (Author), Kalubowila, Udaya (Author), Kato, Norihiro (Author), Wickremasinghe, A. Rajitha (Author) and de Silva, H. Janaka (Author)
Journal TitleBMC Research Notes
Journal Citation4, pp. 1-5
Article Number513
Number of Pages5
Year2011
PublisherBioMed Central Ltd.
Place of PublicationUnited Kingdom
ISSN1756-0500
Digital Object Identifier (DOI)https://doi.org/10.1186/1756-0500-4-513
Web Address (URL)http://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-4-513
Abstract

Background
Non-alcoholic fatty liver disease (NAFLD) is recognized as a metabolic disorder largely seen in urbanized populations. The purpose of this study was to assess prevalence and risk factors for NAFLD in a rural, physically active, economically deprived population in Sri Lanka.

Methods
By visiting individual households in the community, 35-64 year old adults resident in two selected estates in the Nuwara Eliya District of Sri Lanka, were invited to participate in the study. Blood pressure and anthropometric measurements were made on all participants. Blood samples were obtained for the assay of fasting glucose, serum lipids, serum insulin and alanine aminotransferase. NAFLD was diagnosed on established ultrasound criteria for fatty liver in the absence of hepatitis B and C markers and high alcohol consumption.

Results
Of those invited, 403 (65%) participated in the study. Almost all participants were either Indian or Sri Lankan Tamils and 53% were females. Prevalence of NAFLD was 18% in this population. Twice as many males were diagnosed as having NAFLD compared to females. Male sex, high BMI, high waist circumference, high diastolic blood pressure and high plasma glucose levels were significant predictors of NAFLD.

Conclusion
Nearly one in five people in this predominantly Indian Tamil, rural, physically active, economically deprived population had NAFLD. The condition was associated with constituent features of the metabolic syndrome. These results support studies reporting ethnic variations in disease susceptibility and suggest that genetic factors may also play a role in determining disease risk.

KeywordsFatty Liver; Nonalcoholic Fatty Liver Disease; High Waist Circumference; Constituent Feature; Weekly Alcohol Consumption
ANZSRC Field of Research 2020429999. Other health sciences not elsewhere classified
Byline AffiliationsUniversity of Kelaniya, Sri Lanka
National Center for Global Health and Medicine, Japan
Institution of OriginUniversity of Southern Queensland
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