Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
Article
Article Title | Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci |
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ERA Journal ID | 16629 |
Article Category | Article |
Authors | Kooner, Jaspal S. (Author), Saleheem, Danish (Author), Sim, Xueling (Author), Sehmi, Joban (Author), Zhang, Weihua (Author), Frossard, Philippe (Author), Been, Latonya F. (Author), Chia, Kee-Seng (Author), Dimas, Antigone S. (Author), Hassanali, Neelam (Author), Jafar, Tazeen (Author), Jowett, Jeremy B. M. (Author), Li, Xinzhong (Author), Radha, Venkatesan (Author), Rees, Simon D. (Author), Takeuchi, Fumihiko (Author), Young, Robin (Author) and Pinidiyapathirage, Janani M. (Author) |
Journal Title | Nature Genetics |
Journal Citation | 43 (10), pp. 984-989 |
Number of Pages | 17 |
Year | 2011 |
Place of Publication | United States |
ISSN | 1061-4036 |
1546-1718 | |
Digital Object Identifier (DOI) | https://doi.org/10.1038/ng.921 |
Web Address (URL) | https://www.nature.com/articles/ng.921 |
Abstract | We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and 14,458 controls drawn from studies in London, Pakistan and Singapore. We identified 20 independent SNPs associated with T2D at P < 10 -4 for testing in a replication sample of 13,170 cases and 25,398 controls, also all of South Asian ancestry. In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10 -8 to P = 1.9 × 10 -11). SNPs at GRB14 were also associated with insulin sensitivity (P = 5.0 × 10 -4), and SNPs at ST6GAL1 and HNF4A were also associated with pancreatic beta-cell function (P = 0.02 and P = 0.001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D. |
Keywords | adult; article; clinical article; controlled study; female; gene locus; gene replication; genetic association; genetic identification; genetic predisposition; genetic susceptibility; genome analysis; human; insulin sensitivity; male; non insulin dependent diabetes mellitus; Pakistan; pancreas islet beta cell; population genetics; priority journal; Singapore; single nucleotide polymorphism; South Asia; United Kingdom |
Contains Sensitive Content | Does not contain sensitive content |
ANZSRC Field of Research 2020 | 320208. Endocrinology |
310509. Genomics | |
Public Notes | Files associated with this item cannot be displayed due to copyright restrictions. |
Institution of Origin | University of Southern Queensland |
Byline Affiliations | Imperial College London, United Kingdom |
University of Cambridge, United Kingdom | |
National University of Singapore | |
Center for Non-Communicable Diseases, Pakistan | |
University of Oklahoma, United States | |
University of Geneva, Switzerland | |
University of Oxford, United Kingdom | |
Aga Khan University, Pakistan | |
Baker Heart and Diabetes Institute, Australia | |
Madras Diabetes Research Foundation, India | |
University of Birmingham, United Kingdom | |
National Center for Global Health and Medicine, Japan | |
University of Kelaniya, Sri Lanka |
https://research.usq.edu.au/item/q390v/genome-wide-association-study-in-individuals-of-south-asian-ancestry-identifies-six-new-type-2-diabetes-susceptibility-loci
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