Evaluating methods for effective decontamination of central venous access devices needleless connectors in adult hospital patients: A pilot randomised control trial protocol

Article


Flynn, Julie M., Keogh, Samantha, Zhang, Li and Rickard, Claire M.. 2017. "Evaluating methods for effective decontamination of central venous access devices needleless connectors in adult hospital patients: A pilot randomised control trial protocol." Vascular Access. 3 (2), pp. 1-18. https://doi.org/10.3316/informit.632663924727375
Article Title

Evaluating methods for effective decontamination of central
venous access devices needleless connectors in adult hospital patients: A pilot randomised control trial protocol

Article CategoryArticle
AuthorsFlynn, Julie M. (Author), Keogh, Samantha (Author), Zhang, Li (Author) and Rickard, Claire M. (Author)
Journal TitleVascular Access
Journal Citation3 (2), pp. 1-18
Number of Pages18
Year2017
PublisherCanadian Vascular Access Association
Place of PublicationAustralia
Digital Object Identifier (DOI)https://doi.org/10.3316/informit.632663924727375
Web Address (URL)https://journals.cambridgemedia.com.au/va/volume-3-issue-2
Abstract

Background: The importance of decontaminating needleless connectors prior to accessing central venous access devices (CVADs) to prevent CVAD-associated bloodstream infection has been highlighted. However, the optimal decontamination time and solution is still under-evaluated. Aim: This study will compare different decontamination methods of CVAD needleless connectors in adult patients. The aims of this pilot trial are: to assess recruitment feasibility, data collection strategies and proposed methods; and to test the interventions with the control to determine an adequate sample size for a future, larger clinical trial. Design: A single-centre, parallel, pilot randomised control trial (RCT) with a superiority design. Methods: There will be three arms: 70% isopropyl alcohol swab (control);2.0% chlorhexidine gluconate in 70% isopropyl alcohol swab; and a 70%isopropyl alcohol-impregnated cap. The primary outcome of this pilot trial is to assess feasibility for a future, larger clinical trial. The secondary outcome is CVAD-associated bloodstream infection. In total, 120 patients will be recruited over six months with a four-week follow-up. Prospective patients who are scheduled to have a CVAD inserted will be eligible. Randomisation will be computer-generated, central and concealed until allocation. Due to the nature of the interventions it will not be possible to blind clinicians or patients. Discussion: Preventing CVAD-associated bloodstream infection in hospitalised patients is vital. Interventional decontamination techniques that demonstrate superior performance in preventing CVAD-associated bloodstream infection would improve patient outcomes, reduce patient morbidity and mortality, and health care-associated costs.

KeywordsBloodstream infection; CABSI; central venous access device; CVAD; needleless connectors; nursing
ANZSRC Field of Research 2020420506. Sub-acute care
420501. Acute care
420599. Nursing not elsewhere classified
Byline AffiliationsGriffith University
Institution of OriginUniversity of Southern Queensland
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