Evaluating methods for effective decontamination of central venous access devices needleless connectors in adult hospital patients: A pilot randomised control trial protocol
Article
Article Title | Evaluating methods for effective decontamination of central |
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Article Category | Article |
Authors | Flynn, Julie M. (Author), Keogh, Samantha (Author), Zhang, Li (Author) and Rickard, Claire M. (Author) |
Journal Title | Vascular Access |
Journal Citation | 3 (2), pp. 1-18 |
Number of Pages | 18 |
Year | 2017 |
Publisher | Canadian Vascular Access Association |
Place of Publication | Australia |
Digital Object Identifier (DOI) | https://doi.org/10.3316/informit.632663924727375 |
Web Address (URL) | https://journals.cambridgemedia.com.au/va/volume-3-issue-2 |
Abstract | Background: The importance of decontaminating needleless connectors prior to accessing central venous access devices (CVADs) to prevent CVAD-associated bloodstream infection has been highlighted. However, the optimal decontamination time and solution is still under-evaluated. Aim: This study will compare different decontamination methods of CVAD needleless connectors in adult patients. The aims of this pilot trial are: to assess recruitment feasibility, data collection strategies and proposed methods; and to test the interventions with the control to determine an adequate sample size for a future, larger clinical trial. Design: A single-centre, parallel, pilot randomised control trial (RCT) with a superiority design. Methods: There will be three arms: 70% isopropyl alcohol swab (control);2.0% chlorhexidine gluconate in 70% isopropyl alcohol swab; and a 70%isopropyl alcohol-impregnated cap. The primary outcome of this pilot trial is to assess feasibility for a future, larger clinical trial. The secondary outcome is CVAD-associated bloodstream infection. In total, 120 patients will be recruited over six months with a four-week follow-up. Prospective patients who are scheduled to have a CVAD inserted will be eligible. Randomisation will be computer-generated, central and concealed until allocation. Due to the nature of the interventions it will not be possible to blind clinicians or patients. Discussion: Preventing CVAD-associated bloodstream infection in hospitalised patients is vital. Interventional decontamination techniques that demonstrate superior performance in preventing CVAD-associated bloodstream infection would improve patient outcomes, reduce patient morbidity and mortality, and health care-associated costs. |
Keywords | Bloodstream infection; CABSI; central venous access device; CVAD; needleless connectors; nursing |
ANZSRC Field of Research 2020 | 420506. Sub-acute care |
420501. Acute care | |
420599. Nursing not elsewhere classified | |
Byline Affiliations | Griffith University |
Institution of Origin | University of Southern Queensland |
https://research.usq.edu.au/item/q6w52/evaluating-methods-for-effective-decontamination-of-central-venous-access-devices-needleless-connectors-in-adult-hospital-patients-a-pilot-randomised-control-trial-protocol
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