Melanopsin-mediated post-illumination pupil response in the peripheral retina

Article


Joyce, Daniel S., Feigl, Beatrix and Zele, Andrew J.. 2016. "Melanopsin-mediated post-illumination pupil response in the peripheral retina ." Journal of Vision. 16 (8), pp. 1-15. https://doi.org/10.1167/16.8.5
Article Title

Melanopsin-mediated post-illumination pupil response in the peripheral retina

ERA Journal ID22252
Article CategoryArticle
AuthorsJoyce, Daniel S., Feigl, Beatrix and Zele, Andrew J.
Journal TitleJournal of Vision
Journal Citation16 (8), pp. 1-15
Article Number5
Number of Pages15
YearJun 2016
Place of PublicationUnited States
ISSN1534-7362
Digital Object Identifier (DOI)https://doi.org/10.1167/16.8.5
Web Address (URL)https://jov.arvojournals.org/article.aspx?articleid=2527779
Abstract

Intrinsically photosensitive retinal ganglion cells (ipRGCs) regulate pupil size by integrating extrinsic rod and cone signals with intrinsic melanopsin-mediated phototransduction. Light adapted pupil diameter is determined by the corneal flux density (CFD), and for central visual field stimulation the melanopsin-mediated post-illumination pupil response (PIPR) follows this same CFD relationship. Rods, cones, and ipRGCs vary in size, density, and distribution across the retina, but how these differences affect the amplitude and timing of the extrinsic and intrinsic pupil light reflex in the central and peripheral retina is unknown. We determined the relationship between stimulus area and photon flux with stimuli constant for CFD, irradiance, or area at central (0°) and peripheral (20°) eccentricities with high and low melanopsin excitation. We show that the pupil constriction amplitude was similar at both eccentricities and the time to minimum diameter increased as melanopsin excitation increased. In contrast, the peripheral PIPR follows a CFD relationship but with lower amplitude compared with that at the fovea. This indicates differences in the spatial and temporal characteristics of extrinsic and intrinsic ipRGC inputs to the pupil control pathway for the central and peripheral retina. The eccentricity-dependent change in PIPR amplitude may be analogous to the hill of vision observed in visual perimetry; such knowledge is an important precursor to the development of pupil perimetry paradigms to measure the PIPR in select regions of the visual field.

KeywordsipRGC; melanopsin; pupillometry; eccentricity; periphery; corneal flux density
Byline AffiliationsQueensland University of Technology
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