Melanopsin-mediated pupil function is impaired in Parkinson's disease
Article
Article Title | Melanopsin-mediated pupil function is impaired in Parkinson's disease |
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ERA Journal ID | 201487 |
Article Category | Article |
Authors | Joyce, Daniel S., Feigl, Beatrix, Kerr, Graham, Roeder, Luisa and Zele, Andrew J. |
Journal Title | Scientific Reports |
Journal Citation | 8, pp. 1-9 |
Article Number | 7796 |
Number of Pages | 9 |
Year | 17 May 2018 |
Publisher | Nature Publishing Group |
Place of Publication | United Kingdom |
ISSN | 2045-2322 |
Digital Object Identifier (DOI) | https://doi.org/10.1038/s41598-018-26078-0 |
Web Address (URL) | https://www.nature.com/articles/s41598-018-26078-0 |
Abstract | Parkinson's disease (PD) is characterised by non-motor symptoms including sleep and circadian disruption. Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGC) transmit light signals to brain areas controlling circadian rhythms and the pupil light reflex. To determine if non-motor symptoms observed in PD are linked to ipRGC dysfunction, we evaluated melanopsin and rod/cone contributions to the pupil response in medicated participants with PD (n = 17) and controls (n = 12). Autonomic tone was evaluated by measuring pupillary unrest in darkness. In the PD group, there is evidence for an attenuated post-illumination pupil response (PIPR) amplitude and reduced pupil constriction amplitude, and PIPR amplitudes did not correlate with measures of sleep quality, retinal nerve fibre layer thickness, disease severity, or medication dosage. Both groups exhibited similar pupillary unrest. We show that melanopsin- and the rod/cone-photoreceptor contributions to the pupil control pathway are impaired in people with early-stage PD who have no clinically observable ophthalmic abnormalities. Given that ipRGCs project to brain targets involved in arousal, sleep and circadian rhythms, ipRGC dysfunction may underpin some of the non-motor symptoms observed in PD. |
Keywords | Parkinson’s disease |
ANZSRC Field of Research 2020 | 520301. Clinical neuropsychology |
321204. Vision science | |
520206. Psychophysiology | |
Byline Affiliations | Queensland University of Technology |
Stanford University, United States |
https://research.usq.edu.au/item/w3v10/melanopsin-mediated-pupil-function-is-impaired-in-parkinson-s-disease
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