Melanopsin-mediated pupil function is impaired in Parkinson's disease

Article


Joyce, Daniel S., Feigl, Beatrix, Kerr, Graham, Roeder, Luisa and Zele, Andrew J.. 2018. "Melanopsin-mediated pupil function is impaired in Parkinson's disease." Scientific Reports. 8, pp. 1-9. https://doi.org/10.1038/s41598-018-26078-0
Article Title

Melanopsin-mediated pupil function is impaired in Parkinson's disease

ERA Journal ID201487
Article CategoryArticle
AuthorsJoyce, Daniel S., Feigl, Beatrix, Kerr, Graham, Roeder, Luisa and Zele, Andrew J.
Journal TitleScientific Reports
Journal Citation8, pp. 1-9
Article Number7796
Number of Pages9
Year17 May 2018
PublisherNature Publishing Group
Place of PublicationUnited Kingdom
ISSN2045-2322
Digital Object Identifier (DOI)https://doi.org/10.1038/s41598-018-26078-0
Web Address (URL)https://www.nature.com/articles/s41598-018-26078-0
Abstract

Parkinson's disease (PD) is characterised by non-motor symptoms including sleep and circadian disruption. Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGC) transmit light signals to brain areas controlling circadian rhythms and the pupil light reflex. To determine if non-motor symptoms observed in PD are linked to ipRGC dysfunction, we evaluated melanopsin and rod/cone contributions to the pupil response in medicated participants with PD (n = 17) and controls (n = 12). Autonomic tone was evaluated by measuring pupillary unrest in darkness. In the PD group, there is evidence for an attenuated post-illumination pupil response (PIPR) amplitude and reduced pupil constriction amplitude, and PIPR amplitudes did not correlate with measures of sleep quality, retinal nerve fibre layer thickness, disease severity, or medication dosage. Both groups exhibited similar pupillary unrest. We show that melanopsin- and the rod/cone-photoreceptor contributions to the pupil control pathway are impaired in people with early-stage PD who have no clinically observable ophthalmic abnormalities. Given that ipRGCs project to brain targets involved in arousal, sleep and circadian rhythms, ipRGC dysfunction may underpin some of the non-motor symptoms observed in PD.

KeywordsParkinson’s disease
ANZSRC Field of Research 2020520301. Clinical neuropsychology
321204. Vision science
520206. Psychophysiology
Byline AffiliationsQueensland University of Technology
Stanford University, United States
Permalink -

https://research.usq.edu.au/item/w3v10/melanopsin-mediated-pupil-function-is-impaired-in-parkinson-s-disease

Download files


Published Version
s41598-018-26078-0.pdf
License: CC BY 4.0
File access level: Anyone

  • 22
    total views
  • 17
    total downloads
  • 3
    views this month
  • 2
    downloads this month

Export as

Related outputs

Human-Centric Lighting Research and Policy in the Melanopsin Age
Spitschan, Manuel and Joyce, Daniel S.. 2023. "Human-Centric Lighting Research and Policy in the Melanopsin Age ." Policy Insights from Behavioral and Brain Sciences. 10 (2), pp. 237-246. https://doi.org/10.1177/23727322231196896
Age at Onset in Adults with Insomnia: A Latent Profile Analysis
Rasmussen, Elizabeth, Kircanski, Katharina, Rissman, Ariel, Joyce, Daniel, Ottenberg, Juliet and Soehner, Adriane. 2023. "Age at Onset in Adults with Insomnia: A Latent Profile Analysis." 37th Annual Meeting of the Associated Professional Sleep Societies. Indianapolis, United States 03 - 07 Jun 2023 United States. Oxford University Press. https://doi.org/10.1093/sleep/zsad077.0382
Adverse Childhood Experiences Associated with Adult Sleep Duration, Control Over Sleep, and Daytime Sleepiness
Rasmussen, Elizabeth, Ricketts, Emily, Joyce, Daniel, Mensah-Osman, Taylor, Gorovoy, S., Granados, Karla, Prather, Aric, Hale, Lauren, Branas, Charles, Rojo-Wissar, Darlynn and Grandner, Michael. 2023. "Adverse Childhood Experiences Associated with Adult Sleep Duration, Control Over Sleep, and Daytime Sleepiness." 37th Annual Meeting of the Associated Professional Sleep Societies. Indianapolis, United States 03 - 07 Jun 2023 United States. Oxford University Press. https://doi.org/10.1093/sleep/zsad077.0381
Adverse childhood experiences associated with adult insomnia and nightmares
Rasmussen, Elizabeth, Ricketts, Emily, Joyce, Daniel, Mensah-Osman, Taylor, Gorovoy, Suzanne, Granados, Karla, Prather, Aric, Hale, Lauren, Branas, Charles, Rojo-Wissar, Darlynn and Grandner, Michael. 2023. "Adverse childhood experiences associated with adult insomnia and nightmares." 37th Annual Meeting of the Associated Professional Sleep Societies. Indianapolis, United States 03 - 07 Jun 2023 United States. Oxford University Press. https://doi.org/10.1093/sleep/zsad077.0668
Optimizing Light Flash Sequence Duration to Shift Human Circadian Phase
Joyce, Daniel S., Spitschan, Manuel and Zeitzer, Jamie M.. 2022. "Optimizing Light Flash Sequence Duration to Shift Human Circadian Phase." Biology. 11 (12), pp. 1-10. https://doi.org/10.3390/biology11121807
Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes
Joyce, Daniel S., Spitschan, Manuel and Zeitzer, Jamie M.. 2022. "Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes." Proceedings of the Royal Society B: Biological Sciences. 289 (1970), pp. 1-10. https://doi.org/10.1098/rspb.2021.1943
Melanopsin vision: Sensation and perception through intrinsically photosensitive retinal ganglion cells
Joyce, Daniel S., Houser, Kevin W. Houser, Peirson, Stuart N., Zeitzer, Jamie M. and Zele, Andrew J.. 2022. Melanopsin vision: Sensation and perception through intrinsically photosensitive retinal ganglion cells. United Kingdom. Cambridge University Press.
Electric lighting, adolescent sleep and circadian outcomes, and recommendations for improving light health
Ricketts, Emily J., Joyce, Daniel S., Rissman, Ariel J., Burgess, Helen J., Colwell, Christopher S., Lack, Leon C. and Gradisar, Michael. 2022. "Electric lighting, adolescent sleep and circadian outcomes, and recommendations for improving light health." Sleep Medicine Reviews. 64. https://doi.org/10.1016/j.smrv.2022.101667
Color perception and compensation in color deficiencies assessed with hue scaling
Emery, Kara J., Parthasarathy, Mohana Kuppuswamy, Joyce, Daniel S. and Webster, Michael A.. 2021. "Color perception and compensation in color deficiencies assessed with hue scaling." Vision Research. 183, pp. 1-15. https://doi.org/10.1016/j.visres.2021.01.006
Wide gamut lighting and color contrast in anomalous trichromacy
Joyce, Daniel, Whitehead, Lorne A. and Webster, Michael A.. 2021. "Wide gamut lighting and color contrast in anomalous trichromacy." SPIE Optical Engineering + Applications 2021. California, United States 01 - 05 Aug 2021 United States. SPIE. https://doi.org/10.1117/12.2594334
The accuracy of artificial and natural light measurements by actigraphs
Joyce, Daniel, Zele, Andrew J., Feigl, Beatrix and Adhikari, Prakash. 2020. "The accuracy of artificial and natural light measurements by actigraphs." Journal of Sleep Research. 29 (5), pp. 1-7. https://doi.org/10.1111/jsr.12963
Effect of Suvorexant vs Placebo on Total Daytime Sleep Hours in Shift Workers: A Randomized Clinical Trial
Zeitzer, Jamie M., Joyce, Daniel, Mcbean, Amanda, Quevedo, Yvonne L., Hernandez, Beatriz and Holty, Jon-Erik. 2020. "Effect of Suvorexant vs Placebo on Total Daytime Sleep Hours in Shift Workers: A Randomized Clinical Trial." JAMA Network Open. 3 (6), pp. 1-10. https://doi.org/10.1001/jamanetworkopen.2020.6614
Plasticity in perception: insights from color vision deficiencies
Isherwood, Zoey J, Joyce, Daniel S, Parthasarathy, Mohana Kuppuswamy and Webster, Michael A. 2020. "Plasticity in perception: insights from color vision deficiencies." Faculty reviews. 9, pp. 1-9. https://doi.org/10.12703/b/9-8
Auditory psychomotor vigilance testing in older and young adults: a revised threshold setting procedure
Gabel, Virginie, Kass, Mirelle, Joyce, Daniel S., Spitschan, Manuel and Zeitzer, Jamie M.. 2019. "Auditory psychomotor vigilance testing in older and young adults: a revised threshold setting procedure." Sleep and Breathing: international journal of the science and practice of sleep medicine. 23 (3), pp. 1021-1025. https://doi.org/10.1007/s11325-019-01859-7
The Effects of Short-Term Light Adaptation on the Human Post-Illumination Pupil Response
Joyce, Daniel S., Feigl, Beatrix and Zele, Andrew J.. 2016. "The Effects of Short-Term Light Adaptation on the Human Post-Illumination Pupil Response." Investigative Ophthalmology and Visual Science. 57 (13), pp. 5672-5680. https://doi.org/10.1167/iovs.16-19934
Melanopsin-mediated post-illumination pupil response in the peripheral retina
Joyce, Daniel S., Feigl, Beatrix and Zele, Andrew J.. 2016. "Melanopsin-mediated post-illumination pupil response in the peripheral retina ." Journal of Vision. 16 (8), pp. 1-15. https://doi.org/10.1167/16.8.5
Temporal characteristics of melanopsin inputs to the human pupil light reflex
Joyce, Daniel S., Feigl, Beatrix, Cao, Dingcai and Zele, Andrew J.. 2015. "Temporal characteristics of melanopsin inputs to the human pupil light reflex." Vision Research. 107, pp. 58-66. https://doi.org/10.1016/j.visres.2014.12.001
Effect of rod-cone interactions on mesopic visual performance mediated by chromatic and luminance pathways
Zele, Andrew J., Maynard, Michelle L., Joyce, Daniel S. and Cao, Dingcai. 2014. "Effect of rod-cone interactions on mesopic visual performance mediated by chromatic and luminance pathways." Journal of the Optical Society of America A: Optics, Image Science and Vision. 31 (4), pp. A7-A14. https://doi.org/10.1364/JOSAA.31.0000A7