Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes
Article
Joyce, Daniel S., Spitschan, Manuel and Zeitzer, Jamie M.. 2022. "Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes." Proceedings of the Royal Society B: Biological Sciences. 289 (1970), pp. 1-10. https://doi.org/10.1098/rspb.2021.1943
| Article Title | Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes |
|---|---|
| ERA Journal ID | 2111 |
| Article Category | Article |
| Authors | Joyce, Daniel S., Spitschan, Manuel and Zeitzer, Jamie M. |
| Journal Title | Proceedings of the Royal Society B: Biological Sciences |
| Journal Citation | 289 (1970), pp. 1-10 |
| Number of Pages | 10 |
| Year | 2022 |
| Publisher | Royal Society Publishing |
| Place of Publication | United Kingdom |
| ISSN | 0962-8452 |
| 1471-2954 | |
| Digital Object Identifier (DOI) | https://doi.org/10.1098/rspb.2021.1943 |
| Web Address (URL) | https://royalsocietypublishing.org/doi/10.1098/rspb.2021.1943 |
| Abstract | The melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) are characterized by a delayed off-time following the cessation of light stimulation. Here, we exploited this unusual physiologic property to characterize the exquisite sensitivity of the human circadian system to flashed light. In a 34 h in-laboratory between-subjects design, we examined phase shifting in response to variable-intensity (3-9500 photopic lux) flashes at fixed duration (2 ms; n = 28 participants) and variable-duration (10 s- 10 s) flashes at fixed intensity (2000 photopic lux; n = 31 participants). Acute melatonin suppression, objective alertness and subjective sleepiness during the flash sequence were also assessed. We find a dose-response relationship between flash intensity and circadian phase shift, with an indication of a possible threshold-like behaviour. We find a slight parametric relationship between flash duration and circadian phase shift. Consistent with prior studies, we observe no dose-response relationship to either flash intensity or duration and the acute impact of light on melatonin suppression, objective alertness or subjective sleepiness. Our findings are consistent with circadian responses to a sequence of flashes being mediated by rod or cone photoreceptors via ipRGC integration. |
| Keywords | alertness; circadian; light; melatonin; sleep; flash |
| ANZSRC Field of Research 2020 | 520406. Sensory processes, perception and performance |
| 520206. Psychophysiology | |
| Byline Affiliations | Stanford University, United States |
| VA Palo Alto Health Care System, United States | |
| Technical University of Munich, Germany | |
| Max Planck Society, Germany |
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