Vitamin K: history, metabolism, and nutrition in the horse

Article


Skinner, Jazmine E., Cawdell-Smith, A. Judy, Biffin, J. Ray, Regtop, Hubert L. and Bryden, Wayne L.. 2023. "Vitamin K: history, metabolism, and nutrition in the horse ." Animal Production Science. https://doi.org/10.1071/AN22319
Article Title

Vitamin K: history, metabolism, and nutrition in the horse

ERA Journal ID5178
Article CategoryArticle
AuthorsSkinner, Jazmine E., Cawdell-Smith, A. Judy, Biffin, J. Ray, Regtop, Hubert L. and Bryden, Wayne L.
Journal TitleAnimal Production Science
Article NumberAN22319
Number of Pages19
Year04 Apr 2023
PublisherCSIRO Publishing
Place of PublicationAustralia
ISSN0816-1089
1836-0939
1836-5787
Digital Object Identifier (DOI)https://doi.org/10.1071/AN22319
Web Address (URL)https://www.publish.csiro.au/an/AN22319
Abstract

Vitamin K (VK) has long been known for its essential role in blood coagulation. However, over the past decade, evidence has mounted for its intrinsic and essential roles in other functions within the body, including bone metabolism, calcification, brain development and glucose metabolism. Thus, VK should no longer be considered a single-function ‘haemostasis vitamin’, but rather as a ‘multi-function vitamin’. While current research has focused on its emerging role in human nutrition, the role that VK plays in other species such as the horse has not been well described, with most of our current understanding having been extrapolated from other species, especially rodents. This review assesses the current state of knowledge of VK as it pertains to human and animal nutrition, and, where data exist, its metabolism and nutrition in the horse is explored. Future research on the roles of VK as they pertain to horses, particularly extra-hepatic functions, is necessary. Such insight will allow a greater understanding of how VK is metabolised, facilitating the development of recommendations to assist in the health, growth, and longevity of horses.

Keywordsanimal nutrition; equine nutrition; menadione (MD); menaquinones (MK-n); osteocalcin (OC); phylloquinone (PK); vitamin K (VK); vitamin K-dependent proteins (VKDPs)
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020300303. Animal nutrition
300301. Animal growth and development
300999. Veterinary sciences not elsewhere classified
Byline AffiliationsSchool of Agriculture and Environmental Science
Agricure, Australia
University of Queensland
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