Vitamin K: history, metabolism, and nutrition in the horse

Article


Skinner, Jazmine E., Cawdell-Smith, A. Judy, Biffin, J. Ray, Regtop, Hubert L. and Bryden, Wayne L.. 2023. "Vitamin K: history, metabolism, and nutrition in the horse ." Animal Production Science. https://doi.org/10.1071/AN22319
Article Title

Vitamin K: history, metabolism, and nutrition in the horse

ERA Journal ID5178
Article CategoryArticle
AuthorsSkinner, Jazmine E., Cawdell-Smith, A. Judy, Biffin, J. Ray, Regtop, Hubert L. and Bryden, Wayne L.
Journal TitleAnimal Production Science
Article NumberAN22319
Number of Pages19
Year04 Apr 2023
PublisherCSIRO Publishing
Place of PublicationAustralia
ISSN0816-1089
1836-0939
1836-5787
Digital Object Identifier (DOI)https://doi.org/10.1071/AN22319
Web Address (URL)https://www.publish.csiro.au/an/AN22319
Abstract

Vitamin K (VK) has long been known for its essential role in blood coagulation. However, over the past decade, evidence has mounted for its intrinsic and essential roles in other functions within the body, including bone metabolism, calcification, brain development and glucose metabolism. Thus, VK should no longer be considered a single-function ‘haemostasis vitamin’, but rather as a ‘multi-function vitamin’. While current research has focused on its emerging role in human nutrition, the role that VK plays in other species such as the horse has not been well described, with most of our current understanding having been extrapolated from other species, especially rodents. This review assesses the current state of knowledge of VK as it pertains to human and animal nutrition, and, where data exist, its metabolism and nutrition in the horse is explored. Future research on the roles of VK as they pertain to horses, particularly extra-hepatic functions, is necessary. Such insight will allow a greater understanding of how VK is metabolised, facilitating the development of recommendations to assist in the health, growth, and longevity of horses.

Keywordsanimal nutrition; equine nutrition; menadione (MD); menaquinones (MK-n); osteocalcin (OC); phylloquinone (PK); vitamin K (VK); vitamin K-dependent proteins (VKDPs)
Contains Sensitive ContentDoes not contain sensitive content
ANZSRC Field of Research 2020300303. Animal nutrition
300301. Animal growth and development
300999. Veterinary sciences not elsewhere classified
Byline AffiliationsSchool of Agriculture and Environmental Science
Agricure, Australia
University of Queensland
Permalink -

https://research.usq.edu.au/item/y9yyw/vitamin-k-history-metabolism-and-nutrition-in-the-horse

Download files


Published Version
AN22319.pdf
License: CC BY-NC-ND 4.0
File access level: Anyone

  • 48
    total views
  • 29
    total downloads
  • 7
    views this month
  • 6
    downloads this month

Export as

Related outputs

Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation
Kemp, Kate L., Skinner, Jazmine E. and Bertin, François-René. 2024. "Effect of phenylbutazone on insulin secretion in horses with insulin dysregulation." Journal of Veterinary Internal Medicine. 38 (2), pp. 1177-1184. https://doi.org/10.1111/jvim.17013
The Use of Percutaneous Thermal Sensing Microchips to Measure Body Temperature in Horses during and after Exercise Using Three Different Cool-Down Methods
Kang, Hyungsuk, Zsoldos, Rebeka R., Skinner, Jazmine E., Gaughan, John B., Mellor, Vincent A. and Sole-Guitart, Albert. 2022. "The Use of Percutaneous Thermal Sensing Microchips to Measure Body Temperature in Horses during and after Exercise Using Three Different Cool-Down Methods." Animals. 12 (10), pp. 1-20. https://doi.org/10.3390/ani12101267
Pharmacokinetic evaluation of a novel transdermal ketoprofen formulation in healthy dogs
Ravuri, Halley Gora, Satake, Nana, Balmanno, Alexandra, Skinner, Jazmine, Kempster, Samantha and Mills, Paul C.. 2022. "Pharmacokinetic evaluation of a novel transdermal ketoprofen formulation in healthy dogs." Pharmaceutics. 14 (3), pp. 1-11. https://doi.org/10.3390/pharmaceutics14030646
Comparison of post-exercise cooling methods in horses
Kang, H., Zsoldos, R. R., Skinner, J. E., Gaughan, J. B. and Guitart, A. S.. 2021. "Comparison of post-exercise cooling methods in horses." 2021 Equine Science Society Virtual Symposium. Champaign, United States 01 - 04 Jun 2021 United States. https://doi.org/10.1016/j.jevs.2021.103485
Proteomic evaluation of the vitamin K status of horses: application of the Carboxylated Analysis by Ceramic Hydroxyapatite Enrichment (CACHE) method to the plasma of vitamin K supplemented foals
Skinner, Jazmine E., Sadowski, Pawel, Satake, Nana, Regtop, Hubert L., Biffin, Ray, Cawdell-Smith, Allison J. and Bryden, Wayne L.. 2021. "Proteomic evaluation of the vitamin K status of horses: application of the Carboxylated Analysis by Ceramic Hydroxyapatite Enrichment (CACHE) method to the plasma of vitamin K supplemented foals." 2021 Recent Advancement in Animal Nutrition - Australia Conference (RAAN 2021). Gold Coast, Australia 09 - 11 Jun 2021 Australia.
Vitamin K absorption in the horse: intestinal uptake of different vitamers
Skinner, J. E., Cawdell-Smith, A. J., Biffin, J. R., Talbot, A. M., Regtop, H. L. and Bryden, W. L.. 2014. "Vitamin K absorption in the horse: intestinal uptake of different vitamers." 2014 Australasian Equine Science Symposium. Gold Coast, Australia 18 - 20 Jul 2014 Brisbane, Australia.
Vitamin K absorption in the horse: does absorption occur from the hindgut
Regtop, H. L., Talbot, A. M., Biffin, J. R., Skinner, J. E., Cawdell-Smith, A. J. and Bryden, W. L.. 2014. "Vitamin K absorption in the horse: does absorption occur from the hindgut." 2014 Australasian Equine Science Symposium. Gold Coast, Australia 18 - 20 Jul 2014 Brisbane, Australia.
Proteomic profiling of gamma-carboxylated proteins in horse plasma upon vitamin K supplementation
Skinner, Jazmine E., Sadowski, Pawel, Satake, Nana, Regtop, Hubert L., Biffin, Ray, Cawdell-Smith, Allison J. and Bryden, Wayne L.. 2021. "Proteomic profiling of gamma-carboxylated proteins in horse plasma upon vitamin K supplementation." 6th International Vitamin Conference (IVC 2021). Copenhagen, Denmark Copenhagen, Denmark.
Vitamin K and equine osteocalcin: an enigma explored
Skinner, Jazmine Elizabeth. 2020. Vitamin K and equine osteocalcin: an enigma explored. PhD Thesis Doctor of Philosophy. University of Queensland. https://doi.org/10.14264/b8fc040
Equine production systems and the changing role of horses in society
Skinner, Jazmine E., Hilly, Lynette J., Li, Xiuhua, Cawdell-Smith, A .Judy and Bryden, Wayne L.. 2019. "Equine production systems and the changing role of horses in society." Squires, Victor Roy and Bryden, Wayne L. (ed.) Livestock: production, management strategies and challenges. New York, United States. Nova Science Publishers. pp. 389-433
Intestinal absorption of different vitamin K compounds in the horse
Skinner, J. E., Cawdell-Smith, A. J., Biffin, J. R., Talbot, A. M., Regtop, H. L. and Bryden, W. L.. 2015. "Intestinal absorption of different vitamin K compounds in the horse." 2015 Equine Science Society Symposium. Florida, United States of America 26 - 29 May 2015 United States. https://doi.org/10.1016/j.jevs.2015.03.018
Extent of vitamin K absorption from the equine hindgut
Skinner, J. E., Cawdell-Smith, A. J., Regtop, H. L., Talbot, A. M., Biffin, J. R. and Bryden, W. L.. 2015. "Extent of vitamin K absorption from the equine hindgut." 2015 Equine Science Society Symposium. Florida, United States of America 26 - 29 May 2015 United States. https://doi.org/10.1016/j.jevs.2015.03.069